PMID- 38196304
OWN - NLM
STAT- MEDLINE
DCOM- 20240313
LR  - 20240313
IS  - 1097-0347 (Electronic)
IS  - 1043-3074 (Linking)
VI  - 46
IP  - 4
DP  - 2024 Apr
TI  - ALCAM is a biomarker of tumor aggressiveness and worse prognosis in glottic 
      laryngeal squamous cell carcinoma.
PG  - 785-796
LID - 10.1002/hed.27635 [doi]
AB  - BACKGROUND: Laryngeal squamous cell carcinoma (LSCC) is the second most frequent 
      head and neck tumor. Prognosis of patients with LSCC has not improved in recent 
      decades, showing a need for the identification of prognostic biomarkers and new 
      therapeutic targets. Recently, we showed that ALCAM overexpression was associated 
      with glottic LSCC prognosis. OBJECTIVES AND METHODS: Aiming to validate the 
      prognostic value of ALCAM, we evaluate the ALCAM protein levels by 
      immunohistochemistry in 263 glottic LSCC surgically treated with neck dissection. 
      RESULTS: ALCAM was expressed in 48.7% and overexpressed in 36.5% of glottic LSCC 
      samples. ALCAM overexpression was associated with lymph node metastasis 
      (p = 0.030), lymphovascular involvement (p = 0.0002), high-grade tumors 
      (p = 0.025), and tumor relapse (p = 0.043). Multivariate survival analyses showed 
      an overfitting between ALCAM overexpression and lymph node metastasis as a 
      prognostic variable. CONCLUSIONS: High ALCAM expression was associated with an 
      aggressive glottic LSCC profile.
CI  - (c) 2024 Wiley Periodicals LLC.
FAU - Nicolau-Neto, Pedro
AU  - Nicolau-Neto P
AUID- ORCID: 0000-0003-3322-2120
AD  - Programa de Carcinogenese Molecular, Instituto Nacional de Cancer-INCA, Rio de 
      Janeiro, Brazil.
FAU - Peryassu, Bernardo Cacciari
AU  - Peryassu BC
AD  - Secao de Cirurgia de Cabeca e Pescoco, Instituto Nacional de Cancer-INCA, Rio de 
      Janeiro, Brazil.
FAU - de Carvalho, Flavia Nascimento
AU  - de Carvalho FN
AD  - Programa de Carcinogenese Molecular, Instituto Nacional de Cancer-INCA, Rio de 
      Janeiro, Brazil.
FAU - Souza-Santos, Paulo Thiago
AU  - Souza-Santos PT
AD  - Biologia Molecular, Beneficencia Portuguesa de Sao Paulo, Sao Paulo, Brazil.
FAU - Valverde, Priscila
AU  - Valverde P
AD  - Divisao de Patologia, Instituto Nacional de Cancer-INCA, Rio de Janeiro, Brazil.
FAU - Nascimento, Cristina Moreira
AU  - Nascimento CM
AD  - Divisao de Patologia, Instituto Nacional de Cancer-INCA, Rio de Janeiro, Brazil.
FAU - Costa, Izabella
AU  - Costa I
AD  - Secao de Cirurgia de Cabeca e Pescoco, Instituto Nacional de Cancer-INCA, Rio de 
      Janeiro, Brazil.
FAU - Dias, Fernando L
AU  - Dias FL
AD  - Secao de Cirurgia de Cabeca e Pescoco, Instituto Nacional de Cancer-INCA, Rio de 
      Janeiro, Brazil.
FAU - Pinto, Luis Felipe Ribeiro
AU  - Pinto LFR
AD  - Programa de Carcinogenese Molecular, Instituto Nacional de Cancer-INCA, Rio de 
      Janeiro, Brazil.
AD  - Departamento de Bioquimica, Instituto de Biologia Roberto Alcantara Gomes, 
      Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
LA  - eng
GR  - Swiss Bridge Foundation/
GR  - Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro/
GR  - Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/
GR  - Conselho Nacional de Desenvolvimento Cientifico e Tecnologico/
PT  - Journal Article
DEP - 20240109
PL  - United States
TA  - Head Neck
JT  - Head & neck
JID - 8902541
RN  - 0 (Activated-Leukocyte Cell Adhesion Molecule)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (ALCAM protein, human)
SB  - IM
MH  - Humans
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - Activated-Leukocyte Cell Adhesion Molecule
MH  - *Laryngeal Neoplasms
MH  - *Carcinoma, Squamous Cell
MH  - Lymphatic Metastasis
MH  - Biomarkers, Tumor/metabolism
MH  - Neoplasm Recurrence, Local/pathology
MH  - Prognosis
MH  - *Head and Neck Neoplasms/surgery
OTO - NOTNLM
OT  - ALCAM expression
OT  - laryngeal squamous cell carcinoma
OT  - prognostic biomarker
EDAT- 2024/01/10 06:41
MHDA- 2024/03/13 06:47
CRDT- 2024/01/10 02:32
PHST- 2023/12/01 00:00 [revised]
PHST- 2023/06/06 00:00 [received]
PHST- 2023/12/24 00:00 [accepted]
PHST- 2024/03/13 06:47 [medline]
PHST- 2024/01/10 06:41 [pubmed]
PHST- 2024/01/10 02:32 [entrez]
AID - 10.1002/hed.27635 [doi]
PST - ppublish
SO  - Head Neck. 2024 Apr;46(4):785-796. doi: 10.1002/hed.27635. Epub 2024 Jan 9.