PMID- 38196685
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240210
IS  - 2690-7097 (Electronic)
IS  - 2690-7097 (Linking)
VI  - 4
IP  - 4
DP  - 2023 Dec
TI  - A Novel Provider Education Module to Enhance Detection of Alpha-1 Antitrypsin 
      Deficiency.
PG  - 490-501
LID - 10.34197/ats-scholar.2023-0028OC [doi]
AB  - BACKGROUND: Alpha-1 antitrypsin deficiency (AATD) is the most common genetic risk 
      factor for early-onset emphysema. However, AATD continues to be underrecognized 
      and underdiagnosed. Provider awareness about AATD, concerns with testing costs, 
      and limited understanding about therapeutic options contribute to its 
      underdiagnosis. We hypothesized that provider education would improve awareness 
      of AATD and improve screening. OBJECTIVE: To evaluate the impact of a targeted 
      provider education module on AATD screening. METHODS: We developed a web-based 
      education module to address barriers to screening for AATD, deployed the 
      education module using the Medscape Education platform, assessed perceived 
      healthcare provider confidence in AATD screening, and conducted a prospective pre 
      and postintervention study of AATD testing practices at a high-volume academic 
      outpatient subspecialty pulmonary clinic. RESULTS: A total of 11,385 healthcare 
      providers, including eight pulmonologists at our institution, completed the 
      web-based education module. Confidence in identifying patients at high risk for 
      AATD improved after completing the module ("not confident" in AATD screening was 
      7.7% postintervention compared with 19.4% preintervention). The rate of screening 
      patients at high risk for AATD improved more than twofold (AATD screening rate 
      9.7% preintervention vs. 20.4% postintervention; P = 0.004). Among patients 
      screened for AATD in our cohort, 27.2% had a genotype/phenotype or low alpha-1 
      antitrypsin concentration consistent with AATD. CONCLUSION: Targeted healthcare 
      provider education can improve the confidence in testing for AATD. Improvements 
      in provider confidence corresponded to improvements in AATD screening in a 
      subspecialty pulmonary clinic. More than one-fourth of screening tests suggested 
      AATD, underpinning the value of testing in high-risk individuals.
CI  - Copyright (c) 2023 by the American Thoracic Society.
FAU - Schumacher, Ross C
AU  - Schumacher RC
AUID- ORCID: 0000-0002-7577-3599
AD  - Division of Pulmonary, Allergy, and Critical Care Medicine, Department of 
      Medicine, and.
AD  - Lung Health Center, University of Alabama at Birmingham, Birmingham, Alabama.
FAU - Chiu, Chia-Ying
AU  - Chiu CY
AD  - Division of Pulmonary, Allergy, and Critical Care Medicine, Department of 
      Medicine, and.
AD  - Lung Health Center, University of Alabama at Birmingham, Birmingham, Alabama.
FAU - Lubarda, Jovana
AU  - Lubarda J
AD  - Medscape, LLC, New York, New York; and.
FAU - Aboulsaoud, Pakinam
AU  - Aboulsaoud P
AD  - Medscape, LLC, New York, New York; and.
FAU - Bomberger, Jennifer
AU  - Bomberger J
AD  - Medscape, LLC, New York, New York; and.
FAU - Wells, J Michael
AU  - Wells JM
AUID- ORCID: 0000-0001-9612-5454
AD  - Division of Pulmonary, Allergy, and Critical Care Medicine, Department of 
      Medicine, and.
AD  - Lung Health Center, University of Alabama at Birmingham, Birmingham, Alabama.
AD  - Birmingham Veterans Affairs Healthcare System, Birmingham, Alabama.
LA  - eng
GR  - R01 HL148215/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20230817
PL  - United States
TA  - ATS Sch
JT  - ATS scholar
JID - 101774447
CIN - doi: 10.34197/ats-scholar.2023-0128ED
PMC - PMC10773490
OTO - NOTNLM
OT  - alpha-1 antitrypsin deficiency
OT  - chronic obstructive pulmonary disease
OT  - education
EDAT- 2024/01/10 06:42
MHDA- 2024/01/10 06:43
PMCR- 2023/08/17
CRDT- 2024/01/10 03:40
PHST- 2023/02/16 00:00 [received]
PHST- 2023/06/22 00:00 [accepted]
PHST- 2024/01/10 06:43 [medline]
PHST- 2024/01/10 06:42 [pubmed]
PHST- 2024/01/10 03:40 [entrez]
PHST- 2023/08/17 00:00 [pmc-release]
AID - 10.34197/ats-scholar.2023-0028OC [doi]
PST - epublish
SO  - ATS Sch. 2023 Aug 17;4(4):490-501. doi: 10.34197/ats-scholar.2023-0028OC. 
      eCollection 2023 Dec.