PMID- 38199299
OWN - NLM
STAT- MEDLINE
DCOM- 20240219
LR  - 20240410
IS  - 1521-7035 (Electronic)
IS  - 1521-6616 (Linking)
VI  - 260
DP  - 2024 Mar
TI  - The genome-wide association study of serum IgE levels demonstrated a shared 
      genetic background in allergic diseases.
PG  - 109897
LID - S1521-6616(24)00008-1 [pii]
LID - 10.1016/j.clim.2024.109897 [doi]
AB  - Immunoglobulin E (IgE) synthessis is highly related to a variety of atopic 
      diseases, and several genome-wide association studies (GWASs) have demonstrated 
      the association between genes and IgE level. In this study, we conducted the 
      largest genome-wide association study of IgE involving a Taiwanese Han 
      population. Eight independent variants exhibited genome-wide significance. Among 
      them, an intronic SNP of CD28, rs1181388, and an intergenic SNP, rs1002957030, on 
      11q23.2 were identified as novel signals for IgE. Seven of the loci were 
      replicated successfully in a meta-analysis using data on Japanese population. 
      Among all the human leukocyte antigen (HLA) regions, HLA-DQA1*03:02 - 
      HLA-DQB1*03:03 was the most significant haplotype (OR = 1.25, SE = 0.02, 
      FDR = 1.6 x 10(-14)), corresponding to HLA-DQA1 Asp160 and HLA-DQB1 Leu87 amino 
      acid residues. The genetic correlation showed significance between IgE and 
      allergic diseases including asthma, atopic dermatitis, and pollinosis. IgE PRS 
      was significantly correlated with total IgE levels. Furthermore, the top decile 
      IgE polygenic risk score (PRS) group had the highest risk of asthma for the 
      Taiwan Biobank and Biobank Japan cohorts. IgE PRS may be used to aid in 
      predicting the occurrence of allergic reactions before symptoms occur and 
      biomarkers are detectable. Our study provided a more comprehensive understanding 
      of the impact of genomic variants, including complex HLA alleles, on serum IgE 
      levels.
CI  - Copyright (c) 2024 Elsevier Inc. All rights reserved.
FAU - Lu, Hsing-Fang
AU  - Lu HF
AD  - Department of Medical Research, China Medical University Hospital, Taichung 
      404327, Taiwan; Laboratory for Statistical and Translational Genetics, RIKEN 
      Center for Integrative Medical Sciences, Yokohama, Japan.
FAU - Chou, Chen-Hsing
AU  - Chou CH
AD  - PhD Program for Health Science and Industry, College of Health Care, China 
      Medical University, Taichung, Taiwan; Department of Health Services 
      Administration, China Medical University, Taichung, Taiwan.
FAU - Lin, Ying-Ju
AU  - Lin YJ
AD  - Genetic Center, Department of Medical Research, China Medical University 
      Hospital, Taichung, Taiwan; School of Chinese Medicine, China Medical University, 
      Taichung, Taiwan.
FAU - Uchiyama, Shunsuke
AU  - Uchiyama S
AD  - Laboratory for Statistical and Translational Genetics, RIKEN Center for 
      Integrative Medical Sciences, Yokohama, Japan.
FAU - Terao, Chikashi
AU  - Terao C
AD  - Laboratory for Statistical and Translational Genetics, RIKEN Center for 
      Integrative Medical Sciences, Yokohama, Japan; Clinical Research Center, Shizuoka 
      General Hospital, Shizuoka, Japan; The Department of Applied Genetics, The School 
      of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
FAU - Wang, Yu-Wen
AU  - Wang YW
AD  - Department of Medical Research, China Medical University Hospital, Taichung 
      404327, Taiwan.
FAU - Yang, Jai-Sing
AU  - Yang JS
AD  - Department of Medical Research, China Medical University Hospital, China Medical 
      University, Taichung, 404327, Taiwan.
FAU - Liu, Ting-Yuan
AU  - Liu TY
AD  - Department of Medical Research, China Medical University Hospital, Taichung 
      404327, Taiwan.
FAU - Wong, Henry Sung-Ching
AU  - Wong HS
AD  - Graduate Institute of Biomedical Informatics, College of Medical Science and 
      Technology, Taipei Medical University, Taipei, Taiwan.
FAU - Chen, Sean Chun-Chang
AU  - Chen SC
AD  - Graduate Institute of Biomedical Informatics, College of Medical Science and 
      Technology, Taipei Medical University, Taipei, Taiwan.
FAU - Tsai, Fuu-Jen
AU  - Tsai FJ
AD  - Department of Medical Research, China Medical University Hospital, Taichung 
      404327, Taiwan; School of Chinese Medicine, China Medical University, Taichung, 
      Taiwan; Department of Biotechnology and Bioinformatics, Asia University, 
      Taichung, Taiwan. Electronic address: d0704@mail.cmuh.org.tw.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20240108
PL  - United States
TA  - Clin Immunol
JT  - Clinical immunology (Orlando, Fla.)
JID - 100883537
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Humans
MH  - Genome-Wide Association Study
MH  - *Hypersensitivity/genetics
MH  - *Asthma
MH  - Polymorphism, Single Nucleotide
MH  - Immunoglobulin E
MH  - Genetic Predisposition to Disease
OTO - NOTNLM
OT  - Allergy
OT  - genome-wide association study
OT  - human leukocyte antigen
OT  - immunoglobulin E
COIS- Declaration of competing interest All authors declare that they have no other 
      relevant conflicts of interest.
EDAT- 2024/01/11 00:42
MHDA- 2024/02/19 06:44
CRDT- 2024/01/10 20:15
PHST- 2023/08/10 00:00 [received]
PHST- 2023/12/12 00:00 [revised]
PHST- 2024/01/03 00:00 [accepted]
PHST- 2024/02/19 06:44 [medline]
PHST- 2024/01/11 00:42 [pubmed]
PHST- 2024/01/10 20:15 [entrez]
AID - S1521-6616(24)00008-1 [pii]
AID - 10.1016/j.clim.2024.109897 [doi]
PST - ppublish
SO  - Clin Immunol. 2024 Mar;260:109897. doi: 10.1016/j.clim.2024.109897. Epub 2024 Jan 
      8.