PMID- 38201658
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240114
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 16
IP  - 1
DP  - 2024 Jan 4
TI  - And Yet It Moves: Clinical Outcomes and Motion Management in Stereotactic Body 
      Radiation Therapy (SBRT) of Centrally Located Non-Small Cell Lung Cancer (NSCLC): 
      Shedding Light on the Internal Organ at Risk Volume (IRV) Concept.
LID - 10.3390/cancers16010231 [doi]
LID - 231
AB  - The internal organ at risk volume (IRV) concept might improve toxicity profiles 
      in stereotactic body radiation therapy (SBRT) for non-small cell lung cancer 
      (NSCLC). We studied (1) clinical aspects in central vs. peripheral tumors, (2) 
      the IRV concept in central tumors, (3) organ motion, and (4) associated normal 
      tissue complication probabilities (NTCPs). We analyzed patients who received SBRT 
      for NSCLC (clinical aspects, n = 78; motion management, n = 35). We found lower 
      biologically effective doses, larger planning target volume sizes, higher lung 
      doses, and worse locoregional control for central vs. peripheral tumors. Organ 
      motion was greater in males and tall patients (bronchial tree), whereas volume 
      changes were lower in patients with a high body mass index (BMI) (esophagus). 
      Applying the IRV concept (retrospectively, without new optimization), we found an 
      absolute increase of >10% in NTCPs for the bronchial tree in three patients. This 
      study emphasizes the need to optimize methods to balance dose escalation with 
      toxicities in central tumors. There is evidence that organ motion/volume changes 
      could be more pronounced in males and tall patients, and less pronounced in 
      patients with higher BMI. Since recent studies have made efforts to further 
      subclassify central tumors to refine treatment, the IRV concept should be 
      considered for optimal risk assessment.
FAU - Habermann, Felix-Nikolai Oschinka Jegor
AU  - Habermann FOJ
AD  - Department of Radiotherapy and Radiation Oncology, University Medical Center 
      Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany.
AD  - Gottingen Comprehensive Cancer Center (G-CCC), University Medical Center 
      Gottingen, Von-Bar-Str. 2/4, 37075 Gottingen, Germany.
FAU - Schmitt, Daniela
AU  - Schmitt D
AUID- ORCID: 0000-0002-9657-0715
AD  - Department of Radiotherapy and Radiation Oncology, University Medical Center 
      Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany.
AD  - Gottingen Comprehensive Cancer Center (G-CCC), University Medical Center 
      Gottingen, Von-Bar-Str. 2/4, 37075 Gottingen, Germany.
FAU - Failing, Thomas
AU  - Failing T
AUID- ORCID: 0000-0002-4554-7769
AD  - Department of Radiotherapy and Radiation Oncology, University Medical Center 
      Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany.
AD  - Gottingen Comprehensive Cancer Center (G-CCC), University Medical Center 
      Gottingen, Von-Bar-Str. 2/4, 37075 Gottingen, Germany.
AD  - Institute of Medical Physics and Radiation Protection (IMPS), University of 
      Applied Sciences, Wiesenstr. 14, 35390 Giessen, Germany.
FAU - Ziegler, David Alexander
AU  - Ziegler DA
AD  - Department of Radiotherapy and Radiation Oncology, University Medical Center 
      Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany.
AD  - Gottingen Comprehensive Cancer Center (G-CCC), University Medical Center 
      Gottingen, Von-Bar-Str. 2/4, 37075 Gottingen, Germany.
FAU - Fischer, Jann
AU  - Fischer J
AD  - Department of Radiotherapy and Radiation Oncology, University Medical Center 
      Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany.
AD  - Gottingen Comprehensive Cancer Center (G-CCC), University Medical Center 
      Gottingen, Von-Bar-Str. 2/4, 37075 Gottingen, Germany.
FAU - Fischer, Laura Anna
AU  - Fischer LA
AD  - Department of Radiotherapy and Radiation Oncology, University Medical Center 
      Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany.
AD  - Gottingen Comprehensive Cancer Center (G-CCC), University Medical Center 
      Gottingen, Von-Bar-Str. 2/4, 37075 Gottingen, Germany.
FAU - Guhlich, Manuel
AU  - Guhlich M
AD  - Department of Radiotherapy and Radiation Oncology, University Medical Center 
      Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany.
AD  - Gottingen Comprehensive Cancer Center (G-CCC), University Medical Center 
      Gottingen, Von-Bar-Str. 2/4, 37075 Gottingen, Germany.
FAU - Bendrich, Stephanie
AU  - Bendrich S
AD  - Department of Radiotherapy and Radiation Oncology, University Medical Center 
      Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany.
AD  - Gottingen Comprehensive Cancer Center (G-CCC), University Medical Center 
      Gottingen, Von-Bar-Str. 2/4, 37075 Gottingen, Germany.
FAU - Knaus, Olga
AU  - Knaus O
AD  - Department of Radiotherapy and Radiation Oncology, University Medical Center 
      Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany.
AD  - Gottingen Comprehensive Cancer Center (G-CCC), University Medical Center 
      Gottingen, Von-Bar-Str. 2/4, 37075 Gottingen, Germany.
FAU - Overbeck, Tobias Raphael
AU  - Overbeck TR
AUID- ORCID: 0000-0002-2579-0171
AD  - Gottingen Comprehensive Cancer Center (G-CCC), University Medical Center 
      Gottingen, Von-Bar-Str. 2/4, 37075 Gottingen, Germany.
AD  - Department of Hematology and Medical Oncology, University Medical Center 
      Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany.
FAU - Treiber, Hannes
AU  - Treiber H
AUID- ORCID: 0000-0003-4436-5493
AD  - Gottingen Comprehensive Cancer Center (G-CCC), University Medical Center 
      Gottingen, Von-Bar-Str. 2/4, 37075 Gottingen, Germany.
AD  - Department of Hematology and Medical Oncology, University Medical Center 
      Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany.
FAU - von Hammerstein-Equord, Alexander
AU  - von Hammerstein-Equord A
AD  - Gottingen Comprehensive Cancer Center (G-CCC), University Medical Center 
      Gottingen, Von-Bar-Str. 2/4, 37075 Gottingen, Germany.
AD  - Department of Cardio-Thoracic and Vascular Surgery, University Medical Center 
      Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany.
FAU - Koch, Raphael
AU  - Koch R
AUID- ORCID: 0000-0002-2018-5685
AD  - Gottingen Comprehensive Cancer Center (G-CCC), University Medical Center 
      Gottingen, Von-Bar-Str. 2/4, 37075 Gottingen, Germany.
AD  - Department of Hematology and Medical Oncology, University Medical Center 
      Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany.
FAU - El Shafie, Rami
AU  - El Shafie R
AD  - Department of Radiotherapy and Radiation Oncology, University Medical Center 
      Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany.
AD  - Gottingen Comprehensive Cancer Center (G-CCC), University Medical Center 
      Gottingen, Von-Bar-Str. 2/4, 37075 Gottingen, Germany.
FAU - Rieken, Stefan
AU  - Rieken S
AD  - Department of Radiotherapy and Radiation Oncology, University Medical Center 
      Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany.
AD  - Gottingen Comprehensive Cancer Center (G-CCC), University Medical Center 
      Gottingen, Von-Bar-Str. 2/4, 37075 Gottingen, Germany.
FAU - Leu, Martin
AU  - Leu M
AD  - Department of Radiotherapy and Radiation Oncology, University Medical Center 
      Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany.
AD  - Gottingen Comprehensive Cancer Center (G-CCC), University Medical Center 
      Gottingen, Von-Bar-Str. 2/4, 37075 Gottingen, Germany.
FAU - Droge, Leif Hendrik
AU  - Droge LH
AUID- ORCID: 0000-0002-5378-4246
AD  - Department of Radiotherapy and Radiation Oncology, University Medical Center 
      Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany.
AD  - Gottingen Comprehensive Cancer Center (G-CCC), University Medical Center 
      Gottingen, Von-Bar-Str. 2/4, 37075 Gottingen, Germany.
LA  - eng
PT  - Journal Article
DEP - 20240104
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC10778176
OTO - NOTNLM
OT  - IRV
OT  - NSCLC
OT  - PRV
OT  - SBRT
OT  - central tumors
OT  - clinical characteristics
OT  - clinical outcomes
OT  - internal organ at risk volume
OT  - motion management
OT  - planning organ at risk volume
COIS- The authors declare no conflict of interest.
EDAT- 2024/01/11 07:43
MHDA- 2024/01/11 07:44
PMCR- 2024/01/04
CRDT- 2024/01/11 01:07
PHST- 2023/12/04 00:00 [received]
PHST- 2023/12/27 00:00 [revised]
PHST- 2023/12/28 00:00 [accepted]
PHST- 2024/01/11 07:44 [medline]
PHST- 2024/01/11 07:43 [pubmed]
PHST- 2024/01/11 01:07 [entrez]
PHST- 2024/01/04 00:00 [pmc-release]
AID - cancers16010231 [pii]
AID - cancers-16-00231 [pii]
AID - 10.3390/cancers16010231 [doi]
PST - epublish
SO  - Cancers (Basel). 2024 Jan 4;16(1):231. doi: 10.3390/cancers16010231.