PMID- 38201933
OWN - NLM
STAT- MEDLINE
DCOM- 20240112
LR  - 20240113
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 16
IP  - 1
DP  - 2023 Dec 28
TI  - Diet-Wide Association Study for the Incidence of Type 2 Diabetes Mellitus in 
      Community-Dwelling Adults Using the UK Biobank Data.
LID - 10.3390/nu16010103 [doi]
LID - 103
AB  - This longitudinal study used diet-wide association studies (DWAS) to investigate 
      the association between diverse dietary food and nutrient intakes and the onset 
      of type 2 diabetes mellitus (T2DM). Out of 502,505 participants from the UK 
      Biobank, 119,040 with dietary data free of T2DM at the baseline were included, 
      and 3241 developed T2DM during a median follow-up of 11.7 years. The DWAS 
      analysis, which is based on Cox regression models, was used to analyse the 
      associations between dietary food or nutrient intake factors and T2DM risk. The 
      study found that 10 out of 225 dietary factors were significantly associated with 
      the T2DM risk. Total alcohol (HR = 0.86, 0.85-0.92, p = 1.26 x 10(-32)), red wine 
      (HR = 0.89, 0.88-0.94, p = 7.95 x 10(-19)), and fresh tomatoes (HR = 0.92, 
      0.89-0.94, p = 2.3 x 10(-11)) showed a negative association with T2DM risk, 
      whereas sliced buttered bread exhibited a positive association. Additionally, 5 
      out of 21 nutrient intake variables revealed significant associations with the 
      T2DM risk, with iron having the highest protective effect and starch as a risk 
      factor. In conclusion, DWAS is an effective method for discovering novel 
      associations when exploring numerous dietary variables simultaneously and could 
      provide valuable insight into future dietary guidance for T2DM.
FAU - Liu, Jiahao
AU  - Liu J
AUID- ORCID: 0000-0002-9979-5805
AD  - Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, 
      Melbourne, VIC 3010, Australia.
AD  - Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, 
      Melbourne, VIC 3002, Australia.
FAU - Shang, Xianwen
AU  - Shang X
AD  - Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, 
      Melbourne, VIC 3002, Australia.
AD  - Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial 
      People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, 
      China.
FAU - Chen, Yutong
AU  - Chen Y
AD  - Faculty of Medicine, Nursing and Health Science, Monash University, Clayton, VIC 
      3800, Australia.
FAU - Tang, Wentao
AU  - Tang W
AD  - Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, 
      Australia.
FAU - Yusufu, Mayinuer
AU  - Yusufu M
AD  - Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, 
      Melbourne, VIC 3010, Australia.
AD  - Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, 
      Melbourne, VIC 3002, Australia.
FAU - Chen, Ziqi
AU  - Chen Z
AD  - Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, 
      Melbourne, VIC 3010, Australia.
AD  - Centre for Epidemiology and Biostatistics, Melbourne School of Population and 
      Global Health, University of Melbourne, Melbourne, VIC 3053, Australia.
FAU - Chen, Ruiye
AU  - Chen R
AD  - Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, 
      Melbourne, VIC 3010, Australia.
AD  - Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, 
      Melbourne, VIC 3002, Australia.
FAU - Hu, Wenyi
AU  - Hu W
AD  - Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, 
      Melbourne, VIC 3010, Australia.
AD  - Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, 
      Melbourne, VIC 3002, Australia.
FAU - Jan, Catherine
AU  - Jan C
AD  - Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, 
      Melbourne, VIC 3010, Australia.
AD  - Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, 
      Melbourne, VIC 3002, Australia.
FAU - Li, Li
AU  - Li L
AD  - Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, 
      Melbourne, VIC 3010, Australia.
AD  - Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, 
      Melbourne, VIC 3002, Australia.
FAU - He, Mingguang
AU  - He M
AD  - Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, 
      Melbourne, VIC 3002, Australia.
AD  - Ophthalmology, Department of Surgery, University of Melbourne, Melbourne, VIC 
      3052, Australia.
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangzhou 510060, China.
FAU - Zhu, Zhuoting
AU  - Zhu Z
AD  - Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, 
      Melbourne, VIC 3002, Australia.
FAU - Zhang, Lei
AU  - Zhang L
AUID- ORCID: 0000-0003-2343-084X
AD  - Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, 
      Melbourne, VIC 3010, Australia.
AD  - Department of Nephrology, State Key Laboratory of Reproductive Medicine, 
      Children's Hospital of Nanjing Medical University, Nanjing 210008, China.
AD  - Melbourne Sexual Health Centre, Alfred Health, Melbourne, VIC 3053, Australia.
AD  - Central Clinical School, Faculty of Medicine, Monash University, Melbourne, VIC 
      3168, Australia.
LA  - eng
GR  - Z012014075/Fundamental Research Funds of the State Key 14 Laboratory of 
      Ophthalmology, Project of Investigation on Health Status of Employees in 
      Financial Industry in Guangzhou/
GR  - 202002020049/Science and Technology Program of 16 Guangzhou, China/
PT  - Journal Article
DEP - 20231228
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
SB  - IM
MH  - Adult
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/epidemiology/etiology
MH  - Incidence
MH  - Biological Specimen Banks
MH  - Independent Living
MH  - Longitudinal Studies
MH  - UK Biobank
MH  - Diet/adverse effects
MH  - Bread
PMC - PMC10780379
OTO - NOTNLM
OT  - diet
OT  - diet-wide association study
OT  - nutrient
OT  - nutrition
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflicts of interest. The funding source had no role in 
      the design and conduct of the study; collection, management, analysis, and 
      interpretation of the data; preparation, review, or approval of the manuscript; 
      and decision to submit the manuscript for publication.
EDAT- 2024/01/11 07:43
MHDA- 2024/01/12 06:42
PMCR- 2023/12/28
CRDT- 2024/01/11 01:08
PHST- 2023/10/04 00:00 [received]
PHST- 2023/11/30 00:00 [revised]
PHST- 2023/12/07 00:00 [accepted]
PHST- 2024/01/12 06:42 [medline]
PHST- 2024/01/11 07:43 [pubmed]
PHST- 2024/01/11 01:08 [entrez]
PHST- 2023/12/28 00:00 [pmc-release]
AID - nu16010103 [pii]
AID - nutrients-16-00103 [pii]
AID - 10.3390/nu16010103 [doi]
PST - epublish
SO  - Nutrients. 2023 Dec 28;16(1):103. doi: 10.3390/nu16010103.