PMID- 38201964
OWN - NLM
STAT- MEDLINE
DCOM- 20240112
LR  - 20240113
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 16
IP  - 1
DP  - 2023 Dec 30
TI  - Hyperhomocysteinemia in Adult Patients: A Treatable Metabolic Condition.
LID - 10.3390/nu16010135 [doi]
LID - 135
AB  - Hyperhomocysteinemia (HHcy) is recognized as an independent risk factor for 
      various significant medical conditions, yet controversy persists around its 
      assessment and management. The diagnosis of disorders afffecting homocysteine 
      (Hcy) metabolism faces delays due to insufficient awareness of its clinical 
      presentation and unique biochemical characteristics. In cases of arterial or 
      venous thrombotic vascular events, particularly with other comorbidities, it is 
      crucial to consider moderate to severe HHcy. A nutritional approach to HHcy 
      management involves implementing dietary strategies and targeted supplementation, 
      emphasizing key nutrients like vitamin B6, B12, and folate that are crucial for 
      Hcy conversion. Adequate intake of these vitamins, along with betaine 
      supplementation, supports Hcy remethylation. Lifestyle modifications, such as 
      smoking cessation and regular physical activity, complement the nutritional 
      approach to enhance Hcy metabolism. For individuals with HHcy, maintaining a 
      plasma Hcy concentration below 50 mumol/L consistently is vital to lowering the 
      risk of vascular events. Collaboration with healthcare professionals and 
      dietitians is essential for developing personalized dietary plans addressing the 
      specific needs and underlying health conditions. This integrated approach aims to 
      optimize metabolic processes and reduce the associated health risks.
FAU - Gonzalez-Lamuno, Domingo
AU  - Gonzalez-Lamuno D
AUID- ORCID: 0000-0002-7578-241X
AD  - Pediatrics Department, Marques de Valdecilla University Hospital, 39008 
      Santander, Spain.
FAU - Arrieta-Blanco, Francisco Jesus
AU  - Arrieta-Blanco FJ
AUID- ORCID: 0000-0001-7571-0451
AD  - Adult Inborn Errors of Metabolism Unit, Ramon y Cajal University Hospital, 28034 
      Madrid, Spain.
FAU - Fuentes, Elena Dios
AU  - Fuentes ED
AD  - Endocrinology and Nutrition Department, Virgen del Rocio University Hospital, 
      41013 Sevilla, Spain.
FAU - Forga-Visa, Maria Teresa
AU  - Forga-Visa MT
AD  - Endocrinology and Nutrition Department, Clinic Hospital, 08036 Barcelona, Spain.
FAU - Morales-Conejo, Monstserrat
AU  - Morales-Conejo M
AD  - Unit for Congenital Metabolic Diseases and Other Rare Diseases, Internal Medicine 
      Department, 12 de Octubre University Hospital, 28041 Madrid, Spain.
FAU - Pena-Quintana, Luis
AU  - Pena-Quintana L
AUID- ORCID: 0000-0001-6052-5894
AD  - Pediatric Gastroenterology and Nutrition Unit, Insular Materno-Infantil 
      University Hospital Complex, Asociacion Canaria de Investigacion Pediatrica, 
      Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y 
      Nutricion, University of Las Palmas de Gran Canaria, 35016 Las Palmas de Gran 
      Canaria, Spain.
FAU - Vitoria-Minana, Isidro
AU  - Vitoria-Minana I
AUID- ORCID: 0000-0003-4450-1213
AD  - Nutrition and Metabolic Diseases Unit, La Fe University Hospital, 46026 Valencia, 
      Spain.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20231230
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Vitamins)
SB  - IM
MH  - Adult
MH  - Humans
MH  - *Hyperhomocysteinemia/complications/therapy
MH  - *Metabolic Diseases
MH  - Arteries
MH  - Vitamins
MH  - Behavior Therapy
PMC - PMC10780827
OTO - NOTNLM
OT  - Marfanoid habitus
OT  - betaine
OT  - ectopia lentis
OT  - homocysteine
OT  - homocystinuria
OT  - hyperhomocysteinemia
OT  - inborn metabolic diseases
OT  - remethylation
OT  - thrombotic events
OT  - transsulfuration
COIS- The authors declare no conflicts of interest.
EDAT- 2024/01/11 07:43
MHDA- 2024/01/12 06:42
PMCR- 2023/12/30
CRDT- 2024/01/11 01:09
PHST- 2023/11/20 00:00 [received]
PHST- 2023/12/26 00:00 [revised]
PHST- 2023/12/28 00:00 [accepted]
PHST- 2024/01/12 06:42 [medline]
PHST- 2024/01/11 07:43 [pubmed]
PHST- 2024/01/11 01:09 [entrez]
PHST- 2023/12/30 00:00 [pmc-release]
AID - nu16010135 [pii]
AID - nutrients-16-00135 [pii]
AID - 10.3390/nu16010135 [doi]
PST - epublish
SO  - Nutrients. 2023 Dec 30;16(1):135. doi: 10.3390/nu16010135.