PMID- 38202084
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240112
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 13
IP  - 1
DP  - 2023 Dec 22
TI  - The Impact of Blood Morphological Parameters on Treatment Outcomes in Tennis 
      Elbow Patients Receiving Platelet-Rich Plasma (PRP) Therapy: A Prospective Study.
LID - 10.3390/jcm13010077 [doi]
LID - 77
AB  - Platelet-rich plasma (PRP) therapy holds substantial promise for the treatment of 
      tennis elbow, a complex and challenging musculoskeletal condition. The aim of the 
      study was to assess whether there are correlations between the levels of 
      individual morphotic elements determined in whole blood and the outcomes of 
      tennis elbow treatment with PRP injection, as measured using patient-reported 
      outcome measures (PROMs) such as the Visual Analog Scale (VAS), Quick 
      Disabilities of the Arm, Shoulder, and Hand (QDASH), and Patient-Rated Tennis 
      Elbow Evaluation (PRTEE). A prospective analysis was conducted on 107 patients 
      (132 elbows) undergoing lateral epicondylitis treatment with (PRP) injections. 
      Patients completed VAS, PRTEE, and QDASH questionnaires on the day of PRP 
      administration and at established checkpoints (2, 4, 8, 12, 24, 52, and 104 
      weeks). Minimal clinically important difference (MCID) was employed to assess the 
      treatment effects. Then, correlations were measured within each PROM, and the 
      impact of the concentration of individual blood parameters on the MCID outcomes 
      was assessed. Analyzing the relationships between the MCID+ and MCID- groups, 
      significant correlations for the VAS and QDASH scales were observed. The level of 
      individual morphotic elements in the blood may have influenced the treatment 
      outcome, as measured using specific patient-reported outcome measures (PROMs). 
      Regarding the VAS scale, factors favoring a positive treatment outcome included 
      higher values of eosinophils (EOS) and basophils (BASO). For the QDASH scale, 
      these factors were a lower value of mean corpuscular volume (MCV) and a higher 
      mean corpuscular hemoglobin (MCH). The levels of certain blood parameters, such 
      as EOS and BASO, in the current study influenced the classification of patients 
      into MCID+ or MCID- groups, based on the VAS and QDASH scales.
FAU - Szyluk, Karol
AU  - Szyluk K
AUID- ORCID: 0000-0002-0853-9014
AD  - Department of Physiotherapy, Faculty of Health Sciences in Katowice, Medical 
      University of Silesia in Katowice, Medykow 18 Str., 40-752 Katowice, Poland.
AD  - District Hospital of Orthopaedics and Trauma Surgery, Bytomska 62 Str., 41-940 
      Piekary Slaskie, Poland.
FAU - Bubnov, Rostyslav
AU  - Bubnov R
AUID- ORCID: 0000-0003-3148-9884
AD  - Clinical Hospital "Pheophania" of State Affairs Department, Zabolotny Institute 
      of Microbiology and Virology, National Academy of Sciences of Ukraine, 03143 
      Kyiv, Ukraine.
FAU - Jarosz, Alicja
AU  - Jarosz A
AUID- ORCID: 0000-0002-8159-6437
AD  - Department of Biochemistry and Medical Genetics, School of Health Sciences in 
      Katowice, Medical University of Silesia in Katowice, Medykow 18 Str., 40-752 
      Katowice, Poland.
FAU - Regula, Rafal
AU  - Regula R
AD  - District Hospital of Orthopaedics and Trauma Surgery, Bytomska 62 Str., 41-940 
      Piekary Slaskie, Poland.
FAU - Grabowski, Piotr
AU  - Grabowski P
AD  - District Hospital of Orthopaedics and Trauma Surgery, Bytomska 62 Str., 41-940 
      Piekary Slaskie, Poland.
FAU - Iwanicka, Joanna
AU  - Iwanicka J
AUID- ORCID: 0000-0002-3609-9554
AD  - Department of Biochemistry and Medical Genetics, School of Health Sciences in 
      Katowice, Medical University of Silesia in Katowice, Medykow 18 Str., 40-752 
      Katowice, Poland.
FAU - Iwanicki, Tomasz
AU  - Iwanicki T
AUID- ORCID: 0000-0003-0044-3162
AD  - Department of Biochemistry and Medical Genetics, School of Health Sciences in 
      Katowice, Medical University of Silesia in Katowice, Medykow 18 Str., 40-752 
      Katowice, Poland.
FAU - Gierek, Marcin
AU  - Gierek M
AUID- ORCID: 0000-0002-8686-9692
AD  - Center for Burns Treatment, Jana Pawla II Str., 41-100 Siemianowice Slaskie, 
      Poland.
FAU - Sieron, Dominik
AU  - Sieron D
AUID- ORCID: 0000-0001-6532-2594
AD  - Department of Radiology SLS, Inselgroup, Bern University Hospital, University of 
      Bern, Freiburgstrasse 10, 3010 Bern, Switzerland.
FAU - Christe, Andreas
AU  - Christe A
AUID- ORCID: 0000-0002-2355-2591
AD  - Department of Radiology SLS, Inselgroup, Bern University Hospital, University of 
      Bern, Freiburgstrasse 10, 3010 Bern, Switzerland.
AD  - Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, 
      Bern University Hospital, University of Bern, Freiburgstrasse 10, 3010 Bern, 
      Switzerland.
FAU - Niemiec, Pawel
AU  - Niemiec P
AD  - Department of Biochemistry and Medical Genetics, School of Health Sciences in 
      Katowice, Medical University of Silesia in Katowice, Medykow 18 Str., 40-752 
      Katowice, Poland.
LA  - eng
GR  - BNW-NWN-640-2-1-604/23/Medical University of Silesia/
PT  - Journal Article
DEP - 20231222
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC10780100
OTO - NOTNLM
OT  - elbow pain
OT  - lateral elbow tendinopathy
OT  - lateral epicondylitis
OT  - platelet-rich plasma (PRP)
OT  - tennis elbow
COIS- The authors declare no conflicts of interest.
EDAT- 2024/01/11 07:42
MHDA- 2024/01/11 07:43
PMCR- 2023/12/22
CRDT- 2024/01/11 01:09
PHST- 2023/11/16 00:00 [received]
PHST- 2023/12/08 00:00 [revised]
PHST- 2023/12/19 00:00 [accepted]
PHST- 2024/01/11 07:43 [medline]
PHST- 2024/01/11 07:42 [pubmed]
PHST- 2024/01/11 01:09 [entrez]
PHST- 2023/12/22 00:00 [pmc-release]
AID - jcm13010077 [pii]
AID - jcm-13-00077 [pii]
AID - 10.3390/jcm13010077 [doi]
PST - epublish
SO  - J Clin Med. 2023 Dec 22;13(1):77. doi: 10.3390/jcm13010077.