PMID- 38202616
OWN - NLM
STAT- MEDLINE
DCOM- 20240112
LR  - 20240112
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 29
IP  - 1
DP  - 2023 Dec 20
TI  - Optimized DOX Drug Deliveries via Chitosan-Mediated Nanoparticles and Stimuli 
      Responses in Cancer Chemotherapy: A Review.
LID - 10.3390/molecules29010031 [doi]
LID - 31
AB  - Chitosan nanoparticles (NPs) serve as useful multidrug delivery carriers in 
      cancer chemotherapy. Chitosan has considerable potential in drug delivery systems 
      (DDSs) for targeting tumor cells. Doxorubicin (DOX) has limited application due 
      to its resistance and lack of specificity. Chitosan NPs have been used for DOX 
      delivery because of their biocompatibility, biodegradability, drug encapsulation 
      efficiency, and target specificity. In this review, various types of chitosan 
      derivatives are discussed in DDSs to enhance the effectiveness of cancer 
      treatments. Modified chitosan-DOX NP drug deliveries with other compounds also 
      increase the penetration and efficiency of DOX against tumor cells. We also 
      highlight the endogenous stimuli (pH, redox, enzyme) and exogenous stimuli 
      (light, magnetic, ultrasound), and their positive effect on DOX drug delivery via 
      chitosan NPs. Our study sheds light on the importance of chitosan NPs for DOX 
      drug delivery in cancer treatment and may inspire the development of more 
      effective approaches for cancer chemotherapy.
FAU - Imran, HafizMuhammad
AU  - Imran H
AD  - Department of Biochemistry, College of Basic Medical Sciences, Jilin University, 
      Changchun 130021, China.
FAU - Tang, Yixin
AU  - Tang Y
AD  - Department of Biochemistry, College of Basic Medical Sciences, Jilin University, 
      Changchun 130021, China.
FAU - Wang, Siyuan
AU  - Wang S
AD  - Department of Biochemistry, College of Basic Medical Sciences, Jilin University, 
      Changchun 130021, China.
FAU - Yan, Xiuzhang
AU  - Yan X
AD  - Department of Biochemistry, College of Basic Medical Sciences, Jilin University, 
      Changchun 130021, China.
FAU - Liu, Chang
AU  - Liu C
AD  - Department of Biochemistry, College of Basic Medical Sciences, Jilin University, 
      Changchun 130021, China.
FAU - Guo, Lei
AU  - Guo L
AD  - Department of Biochemistry, College of Basic Medical Sciences, Jilin University, 
      Changchun 130021, China.
FAU - Wang, Erlei
AU  - Wang E
AD  - College of Food Science and Engineering, Jilin University, Changchun 130062, 
      China.
FAU - Xu, Caina
AU  - Xu C
AD  - Department of Biochemistry, College of Basic Medical Sciences, Jilin University, 
      Changchun 130021, China.
LA  - eng
GR  - 52073278/National Natural Science Foundation of China/
GR  - 2022JBGS10/"Medical Science + X" Cross-innovation Team of the Norman Bethune 
      Health Science of Jilin University/
GR  - 20230101045JC/Jilin Province Science and Technology Development Program/
GR  - JJKH20231205KJ/Education Department of Jilin Province/
GR  - 2021JC036/Health Commission of Jilin Province/
GR  - 2022-JCXK-09/Fundamental Research Funds for the Central Universities/
PT  - Journal Article
PT  - Review
DEP - 20231220
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 9012-76-4 (Chitosan)
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Humans
MH  - *Chitosan
MH  - Drug Delivery Systems
MH  - Doxorubicin/pharmacology/therapeutic use
MH  - *Nanoparticles
MH  - *Neoplasms/drug therapy
PMC - PMC10780101
OTO - NOTNLM
OT  - chemotherapy
OT  - chitosan NPs
OT  - drug delivery
OT  - drug resistance
OT  - stimuli-sensitive
COIS- The authors declare no conflict of interest.
EDAT- 2024/01/11 07:42
MHDA- 2024/01/12 06:43
PMCR- 2023/12/20
CRDT- 2024/01/11 01:12
PHST- 2023/10/15 00:00 [received]
PHST- 2023/12/15 00:00 [revised]
PHST- 2023/12/16 00:00 [accepted]
PHST- 2024/01/12 06:43 [medline]
PHST- 2024/01/11 07:42 [pubmed]
PHST- 2024/01/11 01:12 [entrez]
PHST- 2023/12/20 00:00 [pmc-release]
AID - molecules29010031 [pii]
AID - molecules-29-00031 [pii]
AID - 10.3390/molecules29010031 [doi]
PST - epublish
SO  - Molecules. 2023 Dec 20;29(1):31. doi: 10.3390/molecules29010031.