PMID- 38203297
OWN - NLM
STAT- MEDLINE
DCOM- 20240112
LR  - 20240116
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 25
IP  - 1
DP  - 2023 Dec 21
TI  - Post-Radiotherapy Exosomal Non-Coding RNA and Hemograms for Early Death 
      Prediction in Patients with Cervical Cancer.
LID - 10.3390/ijms25010126 [doi]
LID - 126
AB  - Concurrent chemo-radiotherapy (CCRT) is linked with accelerated disease 
      progression and early death (ED) in various cancers. This study aimed to assess 
      the association of plasma levels of exosomal non-coding ribonucleic acid (RNA) 
      (ncRNA) and blood cell dynamics with ED prediction in patients with cervical 
      cancer undergoing CCRT. Using propensity score matching, a comparison of complete 
      blood counts (CBCs) was performed among 370 CCRT-treated patients. Differences in 
      ncRNA and messenger RNA (mRNA) expression before and after CCRT in 84 samples 
      from 42 patients (cohort 2) were represented as logarithmic fold change 
      (log(2)FC). Networks were constructed to link the CBCs to the RNAs whose 
      expression correlated with ED. From the key RNAs selected using multiple 
      regression of all RNA combinations in the network, CBC dynamics-associated ncRNAs 
      were functionally characterized using an enrichment analysis. Cohort 1 (120 
      patients) exhibited a correlation between elevated absolute neutrophil counts 
      (ANC) and ED. Cohort 2 exhibited a prevalence of microRNA (miR)-574-3p and long 
      intergenic non-protein coding (LINC)01003 ncRNA, whose expression correlated with 
      ANC and hemoglobin values, respectively. Conversely, acyl-coenzyme A thioesterase 
      9 (ACOT9) mRNA was relevant to all CBC components. An integrative analysis of 
      post-CCRT ncRNA levels and CBC values revealed that the patients with 
      miR-574-3p-LINC01003-ACOT9 log(2)FC) < 0 had a better prospect of 30-month 
      disease-specific survival. These findings indicate that miR-574-3p and LINC01003 
      could serve as ED prognostic biomarkers.
FAU - Cho, Oyeon
AU  - Cho O
AUID- ORCID: 0000-0002-9220-9471
AD  - Gynecologic Cancer Center, Department of Radiation Oncology, Ajou University 
      School of Medicine, Suwon 16499, Republic of Korea.
LA  - eng
GR  - 2018M3A9E8023860/National Research Foundation of Korea/
PT  - Journal Article
DEP - 20231221
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Humans
MH  - Female
MH  - *Uterine Cervical Neoplasms/genetics/radiotherapy
MH  - *MicroRNAs
MH  - Blood Cell Count
MH  - RNA, Messenger
MH  - Leukocyte Count
PMC - PMC10778718
OTO - NOTNLM
OT  - blood cell dynamics
OT  - cervical cancer
OT  - early death prediction
OT  - exosomal non-coding RNAs
OT  - radiotherapy
COIS- The author declares no conflict of interest.
EDAT- 2024/01/11 07:42
MHDA- 2024/01/12 06:42
PMCR- 2023/12/21
CRDT- 2024/01/11 01:17
PHST- 2023/10/24 00:00 [received]
PHST- 2023/12/18 00:00 [revised]
PHST- 2023/12/19 00:00 [accepted]
PHST- 2024/01/12 06:42 [medline]
PHST- 2024/01/11 07:42 [pubmed]
PHST- 2024/01/11 01:17 [entrez]
PHST- 2023/12/21 00:00 [pmc-release]
AID - ijms25010126 [pii]
AID - ijms-25-00126 [pii]
AID - 10.3390/ijms25010126 [doi]
PST - epublish
SO  - Int J Mol Sci. 2023 Dec 21;25(1):126. doi: 10.3390/ijms25010126.