PMID- 38205455
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240112
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 15
IP  - 12
DP  - 2023 Dec
TI  - Per-Oral Endoscopic Myotomy-Induced Gastroesophageal Reflux Disease and Review of 
      the Efficacy of Proton Pump Inhibitors as a Management Strategy: Review of the 
      Literature.
PG  - e50324
LID - 10.7759/cureus.50324 [doi]
LID - e50324
AB  - Per-oral endoscopic myotomy (POEM) is a minimally invasive procedure that is very 
      effective in the treatment of achalasia, a rare esophageal motility disorder. 
      POEM has become the first-line treatment for achalasia, with high success rates 
      reported in the literature. However, a known complication of POEM is 
      gastroesophageal reflux disease (GERD). The exact cause and risk factors of 
      post-POEM GERD are not fully understood; however, a number of factors have played 
      a role in its development. The management of post-POEM GERD is mainly by 
      conservative measures, such as lifestyle changes and medications, like proton 
      pump inhibitors (PPI), which are often the first-line method of treatment. 
      However, surgical procedures, such as fundoplication, may be necessary in some 
      patients. This literature review will discuss the effectiveness of the use of 
      PPIs as a management strategy for post-POEM GERD, the factors that lead to 
      PPI-resistant GERD, and other management strategies utilized in these cases.
CI  - Copyright (c) 2023, Nagi et al.
FAU - Nagi, Talwinder K
AU  - Nagi TK
AD  - Internal Medicine, Florida Atlantic University Charles E. Schmidt College of 
      Medicine, Boca Raton, USA.
FAU - Suarez, Zoilo K
AU  - Suarez ZK
AD  - Internal Medicine, Florida Atlantic University Charles E. Schmidt College of 
      Medicine, Boca Raton, USA.
FAU - Haider, Muhammad Adnan
AU  - Haider MA
AD  - Internal Medicine, Florida Atlantic University Charles E. Schmidt College of 
      Medicine, Boca Raton, USA.
FAU - Holder, Shaniah S
AU  - Holder SS
AD  - Medicine, American University of Barbados School of Medicine, Bridgetown, BRB.
FAU - Vallejo, Charles
AU  - Vallejo C
AD  - Internal Medicine, Florida Atlantic University Charles E. Schmidt College of 
      Medicine, Boca Raton, USA.
FAU - Chaudhari, Sandipkumar S
AU  - Chaudhari SS
AD  - Cardiothoracic Surgery, University of Alabama at Birmingham, Birmingham, USA.
AD  - Family Medicine, University of North Dakota School of Medicine and Health 
      Sciences, Grand Forks, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20231211
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC10777338
OTO - NOTNLM
OT  - esophageal motility disorders
OT  - gastroesophageal reflux disease (gerd)
OT  - laparoscopic heller myotomy
OT  - per-oral endoscopic myotomy
OT  - transoral incisionless fundoplication
COIS- The authors have declared that no competing interests exist.
EDAT- 2024/01/11 07:42
MHDA- 2024/01/11 07:43
PMCR- 2023/12/11
CRDT- 2024/01/11 04:21
PHST- 2023/12/11 00:00 [accepted]
PHST- 2024/01/11 07:43 [medline]
PHST- 2024/01/11 07:42 [pubmed]
PHST- 2024/01/11 04:21 [entrez]
PHST- 2023/12/11 00:00 [pmc-release]
AID - 10.7759/cureus.50324 [doi]
PST - epublish
SO  - Cureus. 2023 Dec 11;15(12):e50324. doi: 10.7759/cureus.50324. eCollection 2023 
      Dec.