PMID- 38205711
OWN - NLM
STAT- Publisher
LR  - 20240111
IS  - 1938-2707 (Electronic)
IS  - 0009-9228 (Linking)
DP  - 2024 Jan 11
TI  - The Safety, Tolerability, and Efficacy of DL-Lactic Acid Syrup (Tonsitin) in 
      Children With Recurrent Tonsillitis: A Pilot Study.
PG  - 99228231222317
LID - 10.1177/00099228231222317 [doi]
AB  - To evaluate Tonsitin (10% DL-lactic acid) safety, tolerability, and efficacy, as 
      a treatment for recurrent tonsillitis (RT) in children. This is a clinical 
      prospective, randomized, double blind pilot study, to evaluate the safety, 
      tolerability and efficacy of Tonsitin in healthy children with RT. Safety 
      evaluated in terms of adverse events (AEs), tolerability in terms of compliance, 
      and efficacy in terms of tonsils' size and frequency of tonsillitis, and quality 
      of life. The study included 51 children. The treatment regimen was tolerable 
      among the participants. Six children experienced AEs, but mostly mild. Tonsil 
      size declined in both groups, but these results did not reach statistical 
      significance. Tonsillitis episodes' frequencies were random and not significant. 
      Tonsitin treatment was found to be feasible in the clinical setup and was well 
      tolerated, and appears to be safe. Study efficacy results did not reach 
      statistical significance.
FAU - Taha, Ahmed
AU  - Taha A
AUID- ORCID: 0000-0003-4554-8531
AD  - Department of Otolaryngology-Head and Neck Surgery, Shamir Medical Center, 
      Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, 
      Israel.
FAU - Yeheskeli, Eyal
AU  - Yeheskeli E
AD  - Department of Otolaryngology-Head and Neck Surgery, Shamir Medical Center, 
      Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, 
      Israel.
FAU - Gavriel, Haim
AU  - Gavriel H
AD  - Department of Otolaryngology-Head and Neck Surgery, Shamir Medical Center, 
      Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, 
      Israel.
FAU - Berkovitch, Matitiahu
AU  - Berkovitch M
AD  - Clinical Pharmacology and Toxicology Unit, Shamir Medical Center, Affiliated to 
      the Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel.
FAU - Mizrakli, Yuval
AU  - Mizrakli Y
AD  - Department of Otolaryngology-Head and Neck Surgery, Shamir Medical Center, 
      Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, 
      Israel.
FAU - Shlamkovitch, Natan
AU  - Shlamkovitch N
AD  - Department of Otolaryngology-Head and Neck Surgery, Shamir Medical Center, 
      Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, 
      Israel.
FAU - Kohn, Elkana
AU  - Kohn E
AD  - Clinical Pharmacology and Toxicology Unit, Shamir Medical Center, Affiliated to 
      the Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel.
LA  - eng
PT  - Journal Article
DEP - 20240111
PL  - United States
TA  - Clin Pediatr (Phila)
JT  - Clinical pediatrics
JID - 0372606
SB  - IM
OTO - NOTNLM
OT  - 10% DL-lactic acid syrup (Tonsitin)
OT  - recurrent tonsillitis
OT  - tonsillar hypertrophy
COIS- Declaration of Conflicting InterestsThe author(s) declared no potential conflicts 
      of interest with respect to the research, authorship, and/or publication of this 
      article.
EDAT- 2024/01/11 07:42
MHDA- 2024/01/11 07:42
CRDT- 2024/01/11 05:44
PHST- 2024/01/11 07:42 [medline]
PHST- 2024/01/11 07:42 [pubmed]
PHST- 2024/01/11 05:44 [entrez]
AID - 10.1177/00099228231222317 [doi]
PST - aheadofprint
SO  - Clin Pediatr (Phila). 2024 Jan 11:99228231222317. doi: 10.1177/00099228231222317.