PMID- 38211681
OWN - NLM
STAT- MEDLINE
DCOM- 20240223
LR  - 20240223
IS  - 1096-0007 (Electronic)
IS  - 0014-4835 (Linking)
VI  - 239
DP  - 2024 Feb
TI  - Early regional changes in retina and choroid of chicks following monocular 
      hemifield form deprivation.
PG  - 109786
LID - S0014-4835(24)00007-1 [pii]
LID - 10.1016/j.exer.2024.109786 [doi]
AB  - To investigate regional changes in the chick retina and choroid after hemifield 
      form deprivation (HFD). Ten chicks were randomly and equally divided into a 
      temporal retinal deprivation (TRD) and nasal retinal deprivation (NRD) group. HFD 
      was induced with half-lateral translucent plastic goggles in the right eye; the 
      left eye was kept untreated. Swept-source optical coherence tomography (SS-OCT) 
      images obtained at 0, 3, and 72 hours (h) were analyzed using customized 
      software. After 72 h of TRD, the retinal thickness (RT) of the treated eyes was 
      significantly less than that of the fellow eyes in the temporal (P = 0.034) 
      rather than the nasal (P = 0.083) region. In the NRD group, the RT of the treated 
      eyes was thinner in both the nasal and temporal regions than that of the fellow 
      eyes (P < 0.01). The RT alterations were more pronounced in the temporal 
      (Delta = -16.86 +/- 7.14 mum) than in the nasal (Delta = -13.44 +/- 4.83 mum) region after 72-h 
      TRD (P = 0.036), whereas the opposite was observed in the NRD group (P = 0.008). 
      The choroidal thickness (ChT) of the treated eyes was less in both the nasal and 
      temporal regions than that of the fellow eyes in both groups after 72-h treatment 
      (P < 0.01). The ChT alterations were more pronounced in the temporal 
      (Delta = -2.48 +/- 8.95 mum) than in the nasal (Delta = 23.65 +/- 13.58 mum) region after 72-h 
      TRD (P = 0.021), whereas the NRD group showed the opposite effect (P = 0.019). 
      HFD in chicks can lead to retinal and choroidal thinning in the corresponding 
      regions.
CI  - Copyright (c) 2024. Published by Elsevier Ltd.
FAU - Peng, Xiaoliao
AU  - Peng X
AD  - Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan 
      University, Shanghai, 200031, China; NHC Key Laboratory of Myopia (Fudan 
      University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences, 
      Shanghai, 200031, China; Shanghai Research Center of Ophthalmology and Optometry, 
      China; Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for 
      Vision Care, China.
FAU - Huang, Yangyi
AU  - Huang Y
AD  - Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan 
      University, Shanghai, 200031, China; NHC Key Laboratory of Myopia (Fudan 
      University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences, 
      Shanghai, 200031, China; Shanghai Research Center of Ophthalmology and Optometry, 
      China; Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for 
      Vision Care, China.
FAU - Wang, Yuliang
AU  - Wang Y
AD  - Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan 
      University, Shanghai, 200031, China; NHC Key Laboratory of Myopia (Fudan 
      University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences, 
      Shanghai, 200031, China; Shanghai Research Center of Ophthalmology and Optometry, 
      China; Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for 
      Vision Care, China.
FAU - Shang, Jianmin
AU  - Shang J
AD  - Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan 
      University, Shanghai, 200031, China; NHC Key Laboratory of Myopia (Fudan 
      University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences, 
      Shanghai, 200031, China; Shanghai Research Center of Ophthalmology and Optometry, 
      China; Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for 
      Vision Care, China.
FAU - Shen, Yang
AU  - Shen Y
AD  - Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan 
      University, Shanghai, 200031, China; NHC Key Laboratory of Myopia (Fudan 
      University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences, 
      Shanghai, 200031, China; Shanghai Research Center of Ophthalmology and Optometry, 
      China; Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for 
      Vision Care, China.
FAU - Chen, Zhi
AU  - Chen Z
AD  - Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan 
      University, Shanghai, 200031, China; NHC Key Laboratory of Myopia (Fudan 
      University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences, 
      Shanghai, 200031, China; Shanghai Research Center of Ophthalmology and Optometry, 
      China; Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for 
      Vision Care, China.
FAU - Zhou, Xingtao
AU  - Zhou X
AD  - Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan 
      University, Shanghai, 200031, China; NHC Key Laboratory of Myopia (Fudan 
      University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences, 
      Shanghai, 200031, China; Shanghai Research Center of Ophthalmology and Optometry, 
      China; Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for 
      Vision Care, China. Electronic address: doctzhouxingtao@163.com.
FAU - Han, Tian
AU  - Han T
AD  - Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan 
      University, Shanghai, 200031, China; NHC Key Laboratory of Myopia (Fudan 
      University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences, 
      Shanghai, 200031, China; Shanghai Research Center of Ophthalmology and Optometry, 
      China; Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for 
      Vision Care, China. Electronic address: docthantian@126.com.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial, Veterinary
DEP - 20240109
PL  - England
TA  - Exp Eye Res
JT  - Experimental eye research
JID - 0370707
SB  - IM
MH  - Animals
MH  - Chickens
MH  - *Choroid
MH  - *Retina
MH  - Tomography, Optical Coherence/methods
OTO - NOTNLM
OT  - Chicks
OT  - Choroid
OT  - Hemifield form deprivation
OT  - Retina
COIS- Declaration of competing interest The authors declare no conflict of interest.
EDAT- 2024/01/12 00:42
MHDA- 2024/02/19 06:42
CRDT- 2024/01/11 19:12
PHST- 2023/06/24 00:00 [received]
PHST- 2023/12/21 00:00 [revised]
PHST- 2024/01/08 00:00 [accepted]
PHST- 2024/02/19 06:42 [medline]
PHST- 2024/01/12 00:42 [pubmed]
PHST- 2024/01/11 19:12 [entrez]
AID - S0014-4835(24)00007-1 [pii]
AID - 10.1016/j.exer.2024.109786 [doi]
PST - ppublish
SO  - Exp Eye Res. 2024 Feb;239:109786. doi: 10.1016/j.exer.2024.109786. Epub 2024 Jan 
      9.