PMID- 38211747
OWN - NLM
STAT- MEDLINE
DCOM- 20240209
LR  - 20240209
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 349
DP  - 2024 Mar 15
TI  - Therapist-supported digital mental health intervention for depressive symptoms: A 
      randomized clinical trial.
PG  - 494-501
LID - S0165-0327(24)00068-5 [pii]
LID - 10.1016/j.jad.2024.01.057 [doi]
AB  - Depression is a chronic and debilitating mental disorder. Despite the existence 
      of several evidence-based treatments, many individuals suffering from depression 
      face myriad structural barriers to accessing timely care which may be alleviated 
      by digital mental health interventions (DMHI). Accordingly, this randomized 
      clinical trial (ClinicalTrials.gov: NCT04738084) investigated the efficacy of a 
      newer version of the therapist-supported and guided DMHI, the Meru Health Program 
      (MHP), which was recently enhanced with heart rate variability biofeedback and 
      lengthened from 8- to 12-weeks duration, among people with elevated depression 
      symptoms (N = 100, mean age 37). Recruited participants were randomized to the 
      MHP (n = 54) or a waitlist control (n = 46) condition for 12 weeks. The MHP group 
      had greater decreases in depression symptoms compared to the waitlist control 
      (d = -0.8). A larger proportion of participants in the MHP group reported a 
      minimal clinically important difference (MCID) in depression symptoms than 
      participants in the waitlist control group (39.1 % vs. 9.8 %, chi(2)(1) = 9.90, 
      p = .002). Similar effects were demonstrated for anxiety symptoms, quality of 
      life, insomnia, and resilience. The results confirm the utility of the enhanced 
      MHP in reducing depression symptoms and associated health burdens.
CI  - Published by Elsevier B.V.
FAU - Forman-Hoffman, Valerie L
AU  - Forman-Hoffman VL
AD  - Meru Health, San Mateo, CA, USA; Department of Epidemiology, University of Iowa, 
      Iowa City, IA, USA.
FAU - Sihvonen, Samuel
AU  - Sihvonen S
AD  - Meru Health, San Mateo, CA, USA.
FAU - Wielgosz, Joseph
AU  - Wielgosz J
AD  - National Center for PTSD Dissemination and Training Division, VA Palo Alto 
      Healthcare System, Palo Alto, CA, USA.
FAU - Kuhn, Eric
AU  - Kuhn E
AD  - National Center for PTSD Dissemination and Training Division, VA Palo Alto 
      Healthcare System, Palo Alto, CA, USA; Department of Psychiatry and Behavioral 
      Sciences, Stanford University, Stanford, CA, USA.
FAU - Nelson, Benjamin W
AU  - Nelson BW
AD  - Meru Health, San Mateo, CA, USA; Department of Psychology and Neuroscience, 
      University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
FAU - Peiper, Nicholas C
AU  - Peiper NC
AD  - Meru Health, San Mateo, CA, USA; Department of Epidemiology and Population 
      Health, University of Louisville, Louisville, KY, USA.
FAU - Gould, Christine E
AU  - Gould CE
AD  - Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, 
      CA, USA; Geriatric Research Education and Clinical Center, VA Palo Alto Health 
      Care System, Palo Alto, CA, USA. Electronic address: cegould@stanford.edu.
LA  - eng
SI  - ClinicalTrials.gov/NCT04738084
GR  - R44 MH126836/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20240109
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
SB  - IM
MH  - Humans
MH  - Adult
MH  - *Depression/therapy/psychology
MH  - Mental Health
MH  - Quality of Life
MH  - *Cognitive Behavioral Therapy/methods
MH  - Anxiety/psychology
OTO - NOTNLM
OT  - Depression
OT  - Health technology mental health services
OT  - Smartphone
COIS- Declaration of competing interest Dr. Peiper reports research support from the 
      National Institute of Mental Health (R44MH126836), Lilly Oncology, Gilead 
      Sciences, and the Norton Healthcare Foundation. Drs. Peiper and Forman-Hoffman 
      report stock options from Meru Health. Drs. Forman-Hoffman and Nelson were 
      employed by Meru Health during the conduct of this research. They are now with 
      Woebot Health and Verily Life Sciences, respectively. Dr. Peiper was employed by 
      Meru Health; he continues to be at the Department of Epidemiology and Population 
      Health, University of Louisville, Louisville, KY. Dr. Gould previously received 
      funding from Meru Health, Inc., for an investigator-initiated study.
EDAT- 2024/01/12 00:42
MHDA- 2024/02/09 06:43
CRDT- 2024/01/11 19:14
PHST- 2023/07/11 00:00 [received]
PHST- 2023/12/15 00:00 [revised]
PHST- 2024/01/04 00:00 [accepted]
PHST- 2024/02/09 06:43 [medline]
PHST- 2024/01/12 00:42 [pubmed]
PHST- 2024/01/11 19:14 [entrez]
AID - S0165-0327(24)00068-5 [pii]
AID - 10.1016/j.jad.2024.01.057 [doi]
PST - ppublish
SO  - J Affect Disord. 2024 Mar 15;349:494-501. doi: 10.1016/j.jad.2024.01.057. Epub 
      2024 Jan 9.