PMID- 38212863
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240114
IS  - 2234-0726 (Print)
IS  - 2234-2451 (Electronic)
IS  - 2234-0726 (Linking)
VI  - 36
IP  - 1
DP  - 2024 Jan 11
TI  - Minimal clinically important difference (MCID), substantial clinical benefit 
      (SCB), and patient-acceptable symptom state (PASS) in patients who have undergone 
      total knee arthroplasty: a systematic review.
PG  - 3
LID - 10.1186/s43019-024-00210-z [doi]
LID - 3
AB  - BACKGROUND: The present systematic review investigated the minimal clinically 
      important difference (MCID), substantial clinical benefit (SCB), and 
      patient-acceptable symptom state (PASS) of several frequent and established PROMs 
      used to assess patients who have undergone TKA. This study was conducted 
      according to the 2020 PRISMA statement. METHODS: In September 2023, PubMed, Web 
      of Science, and Embase were accessed with no time constraint All clinical studies 
      investigating tools to assess the clinical relevance of PROMs used to evaluate 
      patients having received TKA were accessed. Only studies which evaluated the 
      MCID, PASS, or SCB were eligible. The PROMs of interest were the Forgotten Joint 
      Score-12 (FJS-12), the Oxford Knee Score (OKS), the Knee Injury and 
      Osteoarthritis Outcome Score (KOOS) and its related subscales activity of daily 
      living (ADL), pain, quality of life (QoL), sports and recreational activities, 
      and symptoms, the Western Ontario and McMaster Universities Osteoarthritis 
      (WOMAC) score, the Knee Society Score (KSS) and related function score, and the 
      Short Form-12 (SF-12) and Short Form-36 (SF-36). RESULTS: Data from 29,737 
      patients were collected. The overall risk of bias was low to moderate. The great 
      variability of thresholds for MCID, SCB and PASS between questionnaires but also 
      between investigated aspects was noted, whereby MCIDs for the SF-36 appear lower 
      than for knee-specific questionnaires. CONCLUSION: Despite its critical role from 
      a patient's perspective, the dimension of SCB is still neglected in the 
      literature. Moreover, thresholds for the different concepts need to be 
      condition-specific. We encourage authors to specifically report such data in 
      future studies and to adhere to previously reported definitions to allow future 
      comparison. Level of evidence Level IV, systematic review and meta-analysis.
CI  - (c) 2024. The Author(s).
FAU - Migliorini, Filippo
AU  - Migliorini F
AUID- ORCID: 0000-0001-7220-1221
AD  - Department of Orthopaedic, Trauma, and Reconstructive Surgery, RWTH University 
      Medical Centre, Pauwelsstrasse 30, 52074, Aachen, Germany. 
      migliorini.md@gmail.com.
AD  - Department of Orthopedics and Trauma Surgery, Academic Hospital of Bolzano 
      (SABES-ASDAA), Teaching Hospital of the Paracelsus Medical University, 39100, 
      Bolzano, Italy. migliorini.md@gmail.com.
FAU - Maffulli, Nicola
AU  - Maffulli N
AD  - Department of Trauma and Orthopaedic Surgery, Faculty of Medicine and Psychology, 
      University la Sapienza, 00185, Rome, Italy.
AD  - School of Pharmacy and Bioengineering, Keele University Faculty of Medicine, 
      Stoke On Trent, ST4 7QB, UK.
AD  - Centre for Sports and Exercise Medicine, Barts and the London School of Medicine 
      and Dentistry, Mile End Hospital, Queen Mary University of London, London, E1 
      4DG, UK.
FAU - Schafer, Luise
AU  - Schafer L
AD  - Department of Orthopaedic, Trauma, and Reconstructive Surgery, RWTH University 
      Medical Centre, Pauwelsstrasse 30, 52074, Aachen, Germany.
FAU - Simeone, Francesco
AU  - Simeone F
AD  - Department of Orthopedics and Trauma Surgery, Academic Hospital of Bolzano 
      (SABES-ASDAA), Teaching Hospital of the Paracelsus Medical University, 39100, 
      Bolzano, Italy.
FAU - Bell, Andreas
AU  - Bell A
AD  - Department of Orthopaedic and Trauma Surgery, Eifelklinik St.Brigida, 52152, 
      Simmerath, Germany.
FAU - Hofmann, Ulf Krister
AU  - Hofmann UK
AD  - Department of Orthopaedic, Trauma, and Reconstructive Surgery, RWTH University 
      Medical Centre, Pauwelsstrasse 30, 52074, Aachen, Germany.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20240111
PL  - England
TA  - Knee Surg Relat Res
JT  - Knee surgery & related research
JID - 101575761
PMC - PMC10782530
OTO - NOTNLM
OT  - Arthroplasty
OT  - Knee
OT  - MCID
OT  - PASS
OT  - PROMs
OT  - Patient-reported outcome measures
OT  - SCB
COIS- The authors declare that they have any competing interests in this article.
EDAT- 2024/01/12 00:42
MHDA- 2024/01/12 00:43
PMCR- 2024/01/11
CRDT- 2024/01/11 23:42
PHST- 2023/10/29 00:00 [received]
PHST- 2024/01/02 00:00 [accepted]
PHST- 2024/01/12 00:43 [medline]
PHST- 2024/01/12 00:42 [pubmed]
PHST- 2024/01/11 23:42 [entrez]
PHST- 2024/01/11 00:00 [pmc-release]
AID - 10.1186/s43019-024-00210-z [pii]
AID - 210 [pii]
AID - 10.1186/s43019-024-00210-z [doi]
PST - epublish
SO  - Knee Surg Relat Res. 2024 Jan 11;36(1):3. doi: 10.1186/s43019-024-00210-z.