PMID- 38213241
OWN - NLM
STAT- MEDLINE
DCOM- 20240115
LR  - 20240216
IS  - 2589-451X (Electronic)
IS  - 0255-2922 (Print)
IS  - 0255-2922 (Linking)
VI  - 44
IP  - 1
DP  - 2024 Feb
TI  - Caffeic acid 3,4-dihydroxyphenethyl ester prevents colorectal cancer through 
      inhibition of multiple cancer-promoting signal pathways in 
      1,2-Dimethylhydrazine/dextran sodium sulphate mouse model.
PG  - 70-77
LID - 10.19852/j.cnki.jtcm.20231204.001 [doi]
AB  - OBJECTIVE: To elucidate the potential feature and mechanism of the caffeic acid 
      3,4-dihydroxyphenethyl ester (CADPE) molecule, which can prevent colorectal 
      cancer (CRC) in the 1,2-Dimethylhydrazine (DMH)/dextran sodium sulphate 
      (DSS)-induced mouse model. METHODS: Institute of cancer research (ICR) male mice 
      were injected with 20 mg/kg DMH for a week. After that, 2% DSS was administered 
      in the drinking water for another 7 d. The CADPE treatment was given to the 
      DMH/DSS induced male mice at three different periods until their sacrifice. 
      Histopathological examination was used for observing the CRC development at 
      colonic mucosa. Immunohistochemistry (IHC), blood cells smearing and crypt damage 
      scoring methods were used for investigating the anti-inflammation feature of 
      CADPE related to CRC. The reversing targets searching method was applied with 
      artificial intelligence (AI), computer-aided drug designing (CADD) and Ingenuity 
      Pathway Analysis (IPA) techniques for predicting the potential targets and 
      mechanism of CADPE highly related to CRC. RESULTS: The data indicated that CADPE 
      inhibited CRC tumor development in the colitis-associated DMH/DSS induced mouse 
      model after giving the early treatment. CADPE also impeded the acute inflammation 
      by decreasing the infiltration of neutrophils significantly during the initial 
      stage of CRC development. Finally, our data showed that CADPE prevented CRC by 
      blocking active sites of three pivotal protein targets including epidermal growth 
      factor receptor (EGFR), extracellular signal-regulated kinase (ERK) and mammalian 
      target of rapamycin (mTOR) in two major cancer development pathways. CONCLUSIONS: 
      CADPE effectively prevented CRC at early stage of tumor germination in the 
      DMH/DSS mouse model highly likely due to its anti-acute inflammation 
      characteristic and the ability of blocking EGFR, ERK and mTOR activities in two 
      highly related CRC developing pathways.
FAU - Tao, Jin
AU  - Tao J
AD  - College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
FAU - Qian, Zhou
AU  - Qian Z
AD  - College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
FAU - Jichen, Shen
AU  - Jichen S
AD  - Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, 
      Zhejiang University, Hangzhou 310058, China.
FAU - Zhizhong, Zhang
AU  - Zhizhong Z
AD  - Ocean College, Zhoushan Campus of Zhejiang University, Zhoushan 316021, China.
FAU - Xiaoyuan, Lian
AU  - Xiaoyuan L
AD  - College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
LA  - eng
GR  - 81274137, to Stimulate Research Targeted the Energy Metabolism Network of Tumor 
      Cells/National Natural Science Foundation of China Project: the Investigation of 
      Anti-tumor Target System of Traditional Chinese Medicine/
PT  - Journal Article
PL  - China
TA  - J Tradit Chin Med
JT  - Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
JID - 8211546
RN  - IX068S9745 (1,2-Dimethylhydrazine)
RN  - 0 (caffeic acid 3,4-dihydroxyphenethyl ester)
RN  - 0 (Dextrans)
RN  - 0YPR65R21J (sodium sulfate)
RN  - EC 2.7.10.1 (ErbB Receptors)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - 0 (Caffeic Acids)
RN  - 0 (Sulfates)
SB  - IM
MH  - Mice
MH  - Male
MH  - Animals
MH  - 1,2-Dimethylhydrazine/pharmacology
MH  - *Dextrans/pharmacology
MH  - Artificial Intelligence
MH  - *Colorectal Neoplasms/chemically induced/drug therapy
MH  - Signal Transduction
MH  - Inflammation
MH  - ErbB Receptors/genetics
MH  - TOR Serine-Threonine Kinases/genetics
MH  - Mammals
MH  - *Caffeic Acids
MH  - *Sulfates
PMC - PMC10774738
OTO - NOTNLM
OT  - Sarcandra glabra
OT  - caffeic acids
OT  - chemoprevention
OT  - colorectal neoplasms
OT  - inflammation
EDAT- 2024/01/12 06:42
MHDA- 2024/01/15 12:43
PMCR- 2024/02/15
CRDT- 2024/01/12 03:10
PHST- 2024/01/15 12:43 [medline]
PHST- 2024/01/12 06:42 [pubmed]
PHST- 2024/01/12 03:10 [entrez]
PHST- 2024/02/15 00:00 [pmc-release]
AID - 1704694809534-1302738165 [pii]
AID - 0255-2922-44-1-70 [pii]
AID - 10.19852/j.cnki.jtcm.20231204.001 [doi]
PST - ppublish
SO  - J Tradit Chin Med. 2024 Feb;44(1):70-77. doi: 10.19852/j.cnki.jtcm.20231204.001.