PMID- 38213391
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240113
IS  - 1939-4551 (Print)
IS  - 1939-4551 (Electronic)
IS  - 1939-4551 (Linking)
VI  - 16
IP  - 12
DP  - 2023 Dec
TI  - Age-related differences in IgE between childhood and adulthood allergic asthma: 
      Analysis of NHANES 2005-2006.
PG  - 100842
LID - 10.1016/j.waojou.2023.100842 [doi]
LID - 100842
AB  - BACKGROUND: Asthma exhibits varying clinical features in children and adults. 
      However, previous studies have mainly focused on the clinical significance of 
      immunoglobulin E (IgE) in the diagnosis and treatment of asthma, disregarding the 
      characteristics of IgE and its relevant factors. OBJECTIVE: This study aimed to 
      gain a better understanding of the differences in the characteristics of IgE 
      between childhood and adulthood allergic asthma (AA). METHODS: Patients with AA 
      from the 2005 to 2006 National Health and Nutrition Examination Survey (NHANES) 
      were divided into 3 groups based on their current age and onset age of AA: 
      childhood AA (Group 1), childhood-onset adult AA (Group 2), and adulthood-onset 
      AA (Group 3). Intragroup analysis and intergroup comparison were carried out, 
      focusing on the characteristics and relevant factors of IgE, as well as the 
      clinical relevance of total IgE (total IgE, tIgE) and allergen-specific IgE 
      (allergen-specific IgE, sIgE). RESULTS: A total of 424 patients were analyzed, 
      including 187 with childhood AA, 132 with childhood-onset adult AA, and 105 with 
      adulthood-onset AA. The concentration of tIgE was found to be higher in Group 1 
      (268.0, 118.0-686.0 kU/L) than in Group 2 (224.0, 78.0-494.0 kU/L) and Group 3 
      (165.0, 74.4-350.5 kU/L). The sensitization rates did not differ between Group 1 
      and Group 2 but were higher compared with Group 3, particularly for 
      Alternaria-sIgE (50.3% and 46.2% vs 15.2%) and Aspergillus-sIgE (43.9% and 37.1% 
      vs 16.2%). In Group 1, there was a negative correlation between pollen-sIgEs and 
      indoor allergens, but this correlation was not commonly observed in Group 2 and 
      Group 3. On the other hand, in Group 1, environmental chemicals such as 
      phthalates, polyaromatic hydrocarbons, trihalomethanes, and phenols showed a 
      positive correlation with IgE. However, a greater number of chemicals was 
      observed in Group 2 and Group 3, including cotinine, metals, trihalomethanes, 
      phthalates, phenols, and other volatile organic compounds (VOCs). Furthermore, in 
      Group 1, IgE was positively correlated with asthma-related issues such as 
      emergency visits, absenteeism, limited activities, and medication needs. These 
      correlations were less common in Group 2 and Group 3, particularly in Group 3. 
      CONCLUSIONS: There are notable differences in the characteristics and 
      environmental factors of IgE among childhood AA, childhood-onset adult AA, and 
      adulthood-onset AA. Additionally, IgE plays a more significant role in childhood 
      AA due to its higher concentration, fewer relevant environmental chemicals and 
      greater clinical relevance. This may partially explain the age-related features 
      of asthma.
CI  - (c) 2023 The Authors.
FAU - Fang, Heping
AU  - Fang H
AD  - Department of Respiratory Medicine, Children's Hospital of Chongqing Medical 
      University, National Clinical Research Center for Child Health and Disorders, 
      Ministry of Education Key Laboratory of Child Development and Disorders, 
      Chongqing Key Laboratory of Pediatrics, China.
FAU - Li, Juan
AU  - Li J
AD  - Department of Respiratory Medicine, Children's Hospital of Chongqing Medical 
      University, National Clinical Research Center for Child Health and Disorders, 
      Ministry of Education Key Laboratory of Child Development and Disorders, 
      Chongqing Key Laboratory of Pediatrics, China.
FAU - Ren, Luo
AU  - Ren L
AD  - Department of Respiratory Medicine, Children's Hospital of Chongqing Medical 
      University, National Clinical Research Center for Child Health and Disorders, 
      Ministry of Education Key Laboratory of Child Development and Disorders, 
      Chongqing Key Laboratory of Pediatrics, China.
FAU - Liu, Enmei
AU  - Liu E
AD  - Department of Respiratory Medicine, Children's Hospital of Chongqing Medical 
      University, National Clinical Research Center for Child Health and Disorders, 
      Ministry of Education Key Laboratory of Child Development and Disorders, 
      Chongqing Key Laboratory of Pediatrics, China.
LA  - eng
PT  - Journal Article
DEP - 20231119
PL  - United States
TA  - World Allergy Organ J
JT  - The World Allergy Organization journal
JID - 101481283
PMC - PMC10782400
OTO - NOTNLM
OT  - Age groups
OT  - Allergy and immunology
OT  - Asthma
OT  - Immunoglobulin E
OT  - Omalizumab
EDAT- 2024/01/12 06:42
MHDA- 2024/01/12 06:43
PMCR- 2023/11/19
CRDT- 2024/01/12 03:38
PHST- 2023/07/27 00:00 [received]
PHST- 2023/10/03 00:00 [revised]
PHST- 2023/10/24 00:00 [accepted]
PHST- 2024/01/12 06:43 [medline]
PHST- 2024/01/12 06:42 [pubmed]
PHST- 2024/01/12 03:38 [entrez]
PHST- 2023/11/19 00:00 [pmc-release]
AID - S1939-4551(23)00102-3 [pii]
AID - 100842 [pii]
AID - 10.1016/j.waojou.2023.100842 [doi]
PST - epublish
SO  - World Allergy Organ J. 2023 Nov 19;16(12):100842. doi: 
      10.1016/j.waojou.2023.100842. eCollection 2023 Dec.