PMID- 38213786
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240113
IS  - 2589-0042 (Electronic)
IS  - 2589-0042 (Linking)
VI  - 26
IP  - 12
DP  - 2023 Dec 15
TI  - Sbp2l contributes to oligodendrocyte maturation through translational control in 
      Tcf7l2 signaling.
PG  - 108451
LID - 10.1016/j.isci.2023.108451 [doi]
LID - 108451
AB  - Oligodendrocytes (OLs) are the myelin-forming cells in the CNS that support 
      neurons through the insulating sheath of axons. This unique feature and 
      developmental processes are achieved by extrinsic and intrinsic gene expression 
      programs, where RNA-binding proteins can contribute to dynamic and fine-tuned 
      post-transcriptional regulation. Here, we identified SECIS-binding protein 2-like 
      (Sbp2l), which is specifically expressed in OLs by integrated transcriptomics. 
      Histological analysis revealed that Sbp2l is a molecular marker of OL maturation. 
      Sbp2l knockdown (KD) led to suppression of matured OL markers, but not a typical 
      selenoprotein, Gpx4. Transcriptome analysis demonstrated that Sbp2l KD decreased 
      cholesterol-biosynthesis-related genes regulated by Tcf7l2 transcription factor. 
      Indeed, we confirmed the downregulation of Tcf7l2 protein without changing its 
      mRNA in Sbp2l KD OPCs. Furthermore, Sbp2l KO mice showed the decrease of Tcf7l2 
      protein and deficiency of OL maturation. These results suggest that Sbp2l 
      contributes to OL maturation by translational control of Tcf7l2.
CI  - (c) 2023 The Author(s).
FAU - Yugami, Masato
AU  - Yugami M
AD  - Research, Takeda Pharmaceutical Company Limited, 26-1 Muraoka-higashi 2-chome, 
      Fujisawa, Kanagawa 251-8555, Japan.
FAU - Hayakawa-Yano, Yoshika
AU  - Hayakawa-Yano Y
AD  - Division of Neurobiology and Anatomy, Graduate School of Medical and Dental 
      Sciences, Niigata University, 1-757, Asahimachidori, Chuo-ku, Niigata, Niigata 
      951-8510, Japan.
AD  - Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, 
      Shinjuku-ku, Tokyo 160-8582, Japan.
FAU - Ogasawara, Takahisa
AU  - Ogasawara T
AD  - Research, Takeda Pharmaceutical Company Limited, 26-1 Muraoka-higashi 2-chome, 
      Fujisawa, Kanagawa 251-8555, Japan.
FAU - Yokoyama, Kazumasa
AU  - Yokoyama K
AD  - Research, Takeda Pharmaceutical Company Limited, 26-1 Muraoka-higashi 2-chome, 
      Fujisawa, Kanagawa 251-8555, Japan.
FAU - Furukawa, Takako
AU  - Furukawa T
AD  - Division of Neurobiology and Anatomy, Graduate School of Medical and Dental 
      Sciences, Niigata University, 1-757, Asahimachidori, Chuo-ku, Niigata, Niigata 
      951-8510, Japan.
FAU - Hara, Hiroe
AU  - Hara H
AD  - Research, Takeda Pharmaceutical Company Limited, 26-1 Muraoka-higashi 2-chome, 
      Fujisawa, Kanagawa 251-8555, Japan.
FAU - Hashikami, Kentaro
AU  - Hashikami K
AD  - Research, Takeda Pharmaceutical Company Limited, 26-1 Muraoka-higashi 2-chome, 
      Fujisawa, Kanagawa 251-8555, Japan.
FAU - Tsuji, Isamu
AU  - Tsuji I
AD  - Research, Takeda Pharmaceutical Company Limited, 26-1 Muraoka-higashi 2-chome, 
      Fujisawa, Kanagawa 251-8555, Japan.
FAU - Takebayashi, Hirohide
AU  - Takebayashi H
AD  - Division of Neurobiology and Anatomy, Graduate School of Medical and Dental 
      Sciences, Niigata University, 1-757, Asahimachidori, Chuo-ku, Niigata, Niigata 
      951-8510, Japan.
FAU - Araki, Shinsuke
AU  - Araki S
AD  - Research, Takeda Pharmaceutical Company Limited, 26-1 Muraoka-higashi 2-chome, 
      Fujisawa, Kanagawa 251-8555, Japan.
FAU - Okano, Hideyuki
AU  - Okano H
AD  - Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, 
      Shinjuku-ku, Tokyo 160-8582, Japan.
FAU - Yano, Masato
AU  - Yano M
AD  - Division of Neurobiology and Anatomy, Graduate School of Medical and Dental 
      Sciences, Niigata University, 1-757, Asahimachidori, Chuo-ku, Niigata, Niigata 
      951-8510, Japan.
AD  - Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, 
      Shinjuku-ku, Tokyo 160-8582, Japan.
LA  - eng
PT  - Journal Article
DEP - 20231116
PL  - United States
TA  - iScience
JT  - iScience
JID - 101724038
PMC - PMC10783607
OTO - NOTNLM
OT  - Biochemistry
OT  - Biological sciences
OT  - Cell biology
COIS- H.O. is a paid member of the Scientific Advisory Boards of San Bio Co., Ltd. and 
      K Pharma Inc. M. Ya. is a paid member of the Scientific Advisory Board of K 
      Pharma Inc. M.Yu., T.O., K.H., H.H., K.Y., I.T., and S.A. are employees for 
      Takeda Pharmaceutical Company Limited. The remaining authors declare that the 
      research was conducted in the absence of any commercial or financial 
      relationships that could be construed as a potential conflict of interest.
EDAT- 2024/01/12 06:43
MHDA- 2024/01/12 06:44
PMCR- 2023/11/16
CRDT- 2024/01/12 03:46
PHST- 2023/05/24 00:00 [received]
PHST- 2023/10/09 00:00 [revised]
PHST- 2023/11/10 00:00 [accepted]
PHST- 2024/01/12 06:44 [medline]
PHST- 2024/01/12 06:43 [pubmed]
PHST- 2024/01/12 03:46 [entrez]
PHST- 2023/11/16 00:00 [pmc-release]
AID - S2589-0042(23)02528-2 [pii]
AID - 108451 [pii]
AID - 10.1016/j.isci.2023.108451 [doi]
PST - epublish
SO  - iScience. 2023 Nov 16;26(12):108451. doi: 10.1016/j.isci.2023.108451. eCollection 
      2023 Dec 15.