PMID- 38214098
OWN - NLM
STAT- MEDLINE
DCOM- 20240216
LR  - 20240216
IS  - 1097-4652 (Electronic)
IS  - 0021-9541 (Linking)
VI  - 239
IP  - 2
DP  - 2024 Feb
TI  - MCP-5 suppresses osteoclast differentiation through Ccr5 upregulation.
PG  - e31171
LID - 10.1002/jcp.31171 [doi]
AB  - Human monocyte chemoattractant protein-1 (MCP-1) in mice has two orthologs, MCP-1 
      and MCP-5. MCP-1, which is highly expressed in osteoclasts rather than in 
      osteoclast precursor cells, is an important factor in osteoclast differentiation. 
      However, the roles of MCP-5 in osteoclasts are completely unknown. In this study, 
      contrary to MCP-1, MCP-5 was downregulated during receptor activator of nuclear 
      factor kappa B ligand (RANKL)-induced osteoclast differentiation and was 
      considered an inhibitory factor in osteoclast differentiation. The inhibitory 
      role of MCP-5 in osteoclast differentiation was closely related to the increase 
      in Ccr5 expression and the inhibition of IkappaB degradation by RANKL. Transgenic 
      mice expressing MCP-5 controlled by Mx-1 promoter exhibited an increased bone 
      mass because of a decrease in osteoclasts. This result strongly supported that 
      MCP-5 negatively regulated osteoclast differentiation. MCP-5 also prevented 
      severe bone loss caused by RANKL.
CI  - (c) 2024 Wiley Periodicals LLC.
FAU - Kim, Jung Ha
AU  - Kim JH
AUID- ORCID: 0000-0003-2543-043X
AD  - Department of Pharmacology, Chonnam National University Medical School, Gwangju, 
      Republic of Korea.
AD  - Hard-Tissue Biointerface Research Center, School of Dentistry, Chonnam National 
      University, Gwangju, Republic of Korea.
FAU - Kim, Kabsun
AU  - Kim K
AUID- ORCID: 0000-0002-8320-5030
AD  - Department of Pharmacology, Chonnam National University Medical School, Gwangju, 
      Republic of Korea.
FAU - Kim, Inyoung
AU  - Kim I
AUID- ORCID: 0000-0001-9749-1499
AD  - Department of Pharmacology, Chonnam National University Medical School, Gwangju, 
      Republic of Korea.
FAU - Seong, Semun
AU  - Seong S
AUID- ORCID: 0000-0002-6631-7129
AD  - Department of Pharmacology, Chonnam National University Medical School, Gwangju, 
      Republic of Korea.
AD  - Hard-Tissue Biointerface Research Center, School of Dentistry, Chonnam National 
      University, Gwangju, Republic of Korea.
FAU - Koh, Jeong-Tae
AU  - Koh JT
AUID- ORCID: 0000-0001-6279-6487
AD  - Hard-Tissue Biointerface Research Center, School of Dentistry, Chonnam National 
      University, Gwangju, Republic of Korea.
AD  - Department of Pharmacology and Dental Therapeutics, School of Dentistry, Chonnam 
      National University, Gwangju, Republic of Korea.
FAU - Kim, Nacksung
AU  - Kim N
AUID- ORCID: 0000-0002-8132-3981
AD  - Department of Pharmacology, Chonnam National University Medical School, Gwangju, 
      Republic of Korea.
AD  - Hard-Tissue Biointerface Research Center, School of Dentistry, Chonnam National 
      University, Gwangju, Republic of Korea.
LA  - eng
GR  - MSIT; NRF-2019R1A5A2027521/National Research Foundation of Korea/
GR  - RS-2023-00243446/National Research Foundation of Korea/
PT  - Journal Article
DEP - 20240112
PL  - United States
TA  - J Cell Physiol
JT  - Journal of cellular physiology
JID - 0050222
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (NF-kappa B)
RN  - 0 (RANK Ligand)
RN  - 0 (Receptor Activator of Nuclear Factor-kappa B)
RN  - 0 (Monocyte Chemoattractant Proteins)
RN  - 0 (CCR5 protein, mouse)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Mice
MH  - *Cell Differentiation/physiology
MH  - *Membrane Glycoproteins/metabolism
MH  - NF-kappa B/metabolism
MH  - *Osteoclasts/cytology/metabolism
MH  - RANK Ligand/pharmacology/metabolism
MH  - Receptor Activator of Nuclear Factor-kappa B/metabolism
MH  - Up-Regulation
MH  - Mice, Inbred ICR
MH  - Male
MH  - Monocyte Chemoattractant Proteins/genetics/metabolism/pharmacology
MH  - Cells, Cultured
OTO - NOTNLM
OT  - Ccr5
OT  - JNK
OT  - MCP-5
OT  - NF-kappaB
OT  - osteoclast
EDAT- 2024/01/12 06:43
MHDA- 2024/02/14 12:44
CRDT- 2024/01/12 04:22
PHST- 2023/11/24 00:00 [revised]
PHST- 2023/09/27 00:00 [received]
PHST- 2023/12/04 00:00 [accepted]
PHST- 2024/02/14 12:44 [medline]
PHST- 2024/01/12 06:43 [pubmed]
PHST- 2024/01/12 04:22 [entrez]
AID - 10.1002/jcp.31171 [doi]
PST - ppublish
SO  - J Cell Physiol. 2024 Feb;239(2):e31171. doi: 10.1002/jcp.31171. Epub 2024 Jan 12.