PMID- 38214691
OWN - NLM
STAT- Publisher
LR  - 20240112
IS  - 2191-1363 (Electronic)
IS  - 2191-1363 (Linking)
DP  - 2024 Jan 12
TI  - Ethylenediamine Salt Enhances the Solubility and Dissolution of Flurbiprofen.
PG  - e202300262
LID - 10.1002/open.202300262 [doi]
AB  - Drugs that are poorly soluble in water are difficult to absorb orally, resulting 
      in low bioavailability. Flurbiprofen (FLU) is an arylpropionic acid nonsteroidal 
      anti-inflammatory drug belonging to BCS class II, with low water solubility. In 
      this study, a novel flurbiprofen-ethylenediamine salt (FLU-EDA) was successfully 
      prepared via solvent crystallization. Its crystal structure was determined via 
      single-crystal X-ray diffraction (SXRD). Further, the physicochemical properties 
      of FLU-EDA salt were characterized by powder X-ray diffraction (PXRD), 
      differential scanning calorimetry (DSC), and Fourier transform infrared 
      spectroscopy (FT-IR). The solubility and intrinsic dissolution rate (IDR) of 
      FLU-EDA salt in water were investigated. The results showed that compared with 
      FLU, the solubility and IDR of FLU-EDA salt increased by 57-fold and 32-fold, 
      respectively. This indicates that FLU-EDA salt can significantly enhance the 
      solubility and dissolution rate of flurbiprofen in water. This study provides 
      basic data and theory for the development of new formulations of flurbiprofen.
CI  - (c) 2024 The Authors. ChemistryOpen published by Wiley-VCH GmbH.
FAU - Gao, Lei
AU  - Gao L
AD  - College of Food and Pharmaceutical Engineering, Wuzhou University, 543000, 
      Wuzhou, P. R. China.
FAU - Li, Xiaojie
AU  - Li X
AD  - College of Food and Pharmaceutical Engineering, Wuzhou University, 543000, 
      Wuzhou, P. R. China.
FAU - Yan, Xiaolin
AU  - Yan X
AD  - College of Food and Pharmaceutical Engineering, Wuzhou University, 543000, 
      Wuzhou, P. R. China.
FAU - Zhang, Xianrui
AU  - Zhang X
AUID- ORCID: 0000-0002-5038-5143
AD  - College of Food and Pharmaceutical Engineering, Wuzhou University, 543000, 
      Wuzhou, P. R. China.
LA  - eng
GR  - GUIKE AD20159051/Guangxi Science and Technology Base and Talent Project/
GR  - 2023B004/Wuzhou University Foundation/
GR  - S202311354083/Innovation and Entrepreneurship Training program for College 
      students/
PT  - Journal Article
DEP - 20240112
PL  - Germany
TA  - ChemistryOpen
JT  - ChemistryOpen
JID - 101594811
SB  - IM
OTO - NOTNLM
OT  - crystal structure
OT  - ethylenediamine
OT  - flurbiprofen
OT  - solubility
OT  - thermal analysis
EDAT- 2024/01/12 12:41
MHDA- 2024/01/12 12:41
CRDT- 2024/01/12 10:43
PHST- 2023/12/05 00:00 [revised]
PHST- 2023/11/11 00:00 [received]
PHST- 2024/01/12 12:41 [medline]
PHST- 2024/01/12 12:41 [pubmed]
PHST- 2024/01/12 10:43 [entrez]
AID - 10.1002/open.202300262 [doi]
PST - aheadofprint
SO  - ChemistryOpen. 2024 Jan 12:e202300262. doi: 10.1002/open.202300262.