PMID- 38214740
OWN - NLM
STAT- MEDLINE
DCOM- 20240327
LR  - 20240327
IS  - 1432-5233 (Electronic)
IS  - 0940-5429 (Linking)
VI  - 61
IP  - 4
DP  - 2024 Apr
TI  - Retinal neurodegeneration in diabetic retinopathy with systemic hypertension.
PG  - 495-504
LID - 10.1007/s00592-023-02226-5 [doi]
AB  - PURPOSE: To identify the impact of hypertension (HTN) on inner retinal layer 
      thickness in patients with diabetic retinopathy (DR). METHODS: In this 
      retrospective cross-sectional study, participants were divided into three groups: 
      type 2 diabetes patients without DR (DM group), patients with DR (DR group), and 
      patients with both DR and HTN (DR+HTN group). The peripapillary retinal nerve 
      fiber layer (pRNFL) and ganglion cell-inner plexiform layer (GC-IPL) thicknesses, 
      measured using optical coherence tomography, were compared among the groups. 
      RESULTS: A total of 470 eyes were enrolled: 224 eyes in the DM group, 131 eyes in 
      the DR group, and 115 eyes in the DR+HTN group. The mean RNFL thicknesses were 
      95.0 +/- 7.7, 92.5 +/- 10.1, and 89.2 +/- 11.2 mum, and the mean GC-IPL thicknesses were 
      84.0 +/- 5.7, 82.0 +/- 7.6, and 79.2 +/- 8.1 mum in each group, respectively (all 
      P < 0.001). In the DR+HTN group, the DR stage showed a significant association 
      with pRNFL (B = - 5.38, P = 0.014) and GC-IPL (B = - 5.18, P = 0.001) thicknesses 
      in multivariate analyses. Subgroup analyses revealed that pRNFL (P = 0.007) and 
      GC-IPL (P = 0.005) thicknesses decreased significantly as DR progressed only in 
      the DR+HTN group. CONCLUSIONS: Patients with both DR and HTN exhibited much 
      thinner pRNFL and GC-IPL, compared with patients with DR only. These results may 
      have been related to the amplified diabetic retinal neurodegeneration and 
      synergistic impact of ischemia in DR patients with concurrent HTN. Additionally, 
      the progression of DR resulted in more severe inner retinal damage when combined 
      with HTN.
CI  - (c) 2024. Springer-Verlag Italia S.r.l., part of Springer Nature.
FAU - Sung, Jae-Yun
AU  - Sung JY
AD  - Department of Ophthalmology, Chungnam National University Sejong Hospital, 
      Sejong, Republic of Korea.
FAU - Kim, Jae-Jun
AU  - Kim JJ
AD  - Department of Ophthalmology, Konyang University Hospital, Konyang University 
      College of Medicine, #1643 Gwanjeo-dong, Seo-gu, Daejeon, Republic of Korea.
FAU - Hwang, Jae-Yul
AU  - Hwang JY
AD  - Department of Ophthalmology, Chungnam National University Hospital, Daejeon, 
      Republic of Korea.
FAU - Lee, Min-Woo
AU  - Lee MW
AUID- ORCID: 0000-0002-5614-077X
AD  - Department of Ophthalmology, Konyang University Hospital, Konyang University 
      College of Medicine, #1643 Gwanjeo-dong, Seo-gu, Daejeon, Republic of Korea. 
      bogus1105@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20240112
PL  - Germany
TA  - Acta Diabetol
JT  - Acta diabetologica
JID - 9200299
SB  - IM
MH  - Humans
MH  - *Diabetic Retinopathy/complications
MH  - Retrospective Studies
MH  - Retinal Ganglion Cells
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Cross-Sectional Studies
MH  - *Hypertension/complications
MH  - Tomography, Optical Coherence/methods
OTO - NOTNLM
OT  - Diabetic retinopathy
OT  - Ganglion cell-inner plexfirm layer
OT  - Hypertension
OT  - Optical coherence tomography
OT  - Retinal nerve fiber layer
EDAT- 2024/01/12 12:41
MHDA- 2024/03/27 06:43
CRDT- 2024/01/12 11:05
PHST- 2023/09/17 00:00 [received]
PHST- 2023/12/12 00:00 [accepted]
PHST- 2024/03/27 06:43 [medline]
PHST- 2024/01/12 12:41 [pubmed]
PHST- 2024/01/12 11:05 [entrez]
AID - 10.1007/s00592-023-02226-5 [pii]
AID - 10.1007/s00592-023-02226-5 [doi]
PST - ppublish
SO  - Acta Diabetol. 2024 Apr;61(4):495-504. doi: 10.1007/s00592-023-02226-5. Epub 2024 
      Jan 12.