PMID- 38214957
OWN - NLM
STAT- MEDLINE
DCOM- 20240214
LR  - 20240214
IS  - 1936-086X (Electronic)
IS  - 1936-0851 (Linking)
VI  - 18
IP  - 6
DP  - 2024 Feb 13
TI  - Self-Aligning Nanojunctions for Integrated Single-Molecule Circuits.
PG  - 4972-4980
LID - 10.1021/acsnano.3c10844 [doi]
AB  - Robust, high-yield integration of nanoscale components such as graphene 
      nanoribbons, nanoparticles, or single-molecules with conventional electronic 
      circuits has proven to be challenging. This difficulty arises because the 
      contacts to these nanoscale devices must be precisely fabricated with 
      angstrom-level resolution to make reliable connections, and at manufacturing 
      scales this cannot be achieved with even the highest-resolution lithographic 
      tools. Here we introduce an approach that circumvents this issue by precisely 
      creating nanometer-scale gaps between metallic carbon electrodes by using a 
      self-aligning, solution-phase process, which allows facile integration with 
      conventional electronic systems with yields approaching 50%. The electrode 
      separation is controlled by covalently binding metallic single-walled carbon 
      nanotube (mCNT) electrodes to individual DNA duplexes to create mCNT-DNA-mCNT 
      nanojunctions, where the gap is precisely matched to the DNA length. These 
      junctions are then integrated with top-down lithographic techniques to create 
      single-molecule circuits that have electronic properties dominated by the DNA in 
      the junction, have reproducible conductance values with low dispersion, and are 
      stable and robust enough to be utilized as active, high-specificity electronic 
      biosensors for dynamic single-molecule detection of specific oligonucleotides, 
      such as those related to the SARS-CoV-2 genome. This scalable approach for 
      high-yield integration of nanometer-scale devices will enable opportunities for 
      manufacturing of hybrid electronic systems for a wide range of applications.
FAU - Liu, Bo
AU  - Liu B
AUID- ORCID: 0000-0003-4627-4456
AD  - Biodesign Center for Bioelectronics and Biosensors at Arizona State University, 
      Tempe, Arizona 85287, United States.
FAU - Demir, Busra
AU  - Demir B
AUID- ORCID: 0000-0002-3911-2291
AD  - Bionanodesign Laboratory, Department of Biomedical Engineering, TOBB University 
      of Economics and Technology, Ankara 06560, Turkey.
AD  - Department of Materials Science and Nanotechnology Engineering, TOBB University 
      of Economics and Technology, Ankara 06560, Tureky.
FAU - Gultakti, Caglanaz Akin
AU  - Gultakti CA
AUID- ORCID: 0000-0002-0227-1002
AD  - Bionanodesign Laboratory, Department of Biomedical Engineering, TOBB University 
      of Economics and Technology, Ankara 06560, Turkey.
AD  - Department of Materials Science and Nanotechnology Engineering, TOBB University 
      of Economics and Technology, Ankara 06560, Tureky.
FAU - Marrs, Jonathan
AU  - Marrs J
AUID- ORCID: 0000-0001-6434-2980
AD  - Department of Electrical and Computer Engineering, University of California, 
      Davis, Davis, California 95616, United States.
FAU - Gong, Yichen
AU  - Gong Y
AD  - Biodesign Center for Bioelectronics and Biosensors at Arizona State University, 
      Tempe, Arizona 85287, United States.
FAU - Li, Ruihao
AU  - Li R
AD  - Biodesign Center for Bioelectronics and Biosensors at Arizona State University, 
      Tempe, Arizona 85287, United States.
FAU - Oren, Ersin Emre
AU  - Oren EE
AUID- ORCID: 0000-0001-5902-083X
AD  - Bionanodesign Laboratory, Department of Biomedical Engineering, TOBB University 
      of Economics and Technology, Ankara 06560, Turkey.
AD  - Department of Materials Science and Nanotechnology Engineering, TOBB University 
      of Economics and Technology, Ankara 06560, Tureky.
FAU - Hihath, Joshua
AU  - Hihath J
AUID- ORCID: 0000-0002-2949-9293
AD  - Biodesign Center for Bioelectronics and Biosensors at Arizona State University, 
      Tempe, Arizona 85287, United States.
AD  - Department of Electrical and Computer Engineering, University of California, 
      Davis, Davis, California 95616, United States.
AD  - School of Electrical, Computer, and Energy Engineering, Arizona State University, 
      Tempe, Arizona 85287, United States.
LA  - eng
PT  - Journal Article
DEP - 20240112
PL  - United States
TA  - ACS Nano
JT  - ACS nano
JID - 101313589
RN  - 0 (Nanotubes, Carbon)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - *Nanotechnology/methods
MH  - Electronics
MH  - *Nanotubes, Carbon/chemistry
MH  - Electrodes
MH  - DNA
OTO - NOTNLM
OT  - biosensors
OT  - carbon nanotubes
OT  - molecular devices
OT  - nanoelectronics
OT  - nanojunction
OT  - self-alignment
OT  - single-molecule electronics
EDAT- 2024/01/12 12:41
MHDA- 2024/02/14 12:43
CRDT- 2024/01/12 11:53
PHST- 2024/02/14 12:43 [medline]
PHST- 2024/01/12 12:41 [pubmed]
PHST- 2024/01/12 11:53 [entrez]
AID - 10.1021/acsnano.3c10844 [doi]
PST - ppublish
SO  - ACS Nano. 2024 Feb 13;18(6):4972-4980. doi: 10.1021/acsnano.3c10844. Epub 2024 
      Jan 12.