PMID- 38215646
OWN - NLM
STAT- MEDLINE
DCOM- 20240202
LR  - 20240206
IS  - 1879-1379 (Electronic)
IS  - 0022-3956 (Linking)
VI  - 170
DP  - 2024 Feb
TI  - Serum brain-derived neurotrophic factor concentration is different between autism 
      spectrum disorders and intellectual disability children and adolescents.
PG  - 355-360
LID - S0022-3956(24)00001-3 [pii]
LID - 10.1016/j.jpsychires.2024.01.001 [doi]
AB  - PURPOSE: Recent studies showed that mature brain-derived neurotrophic factor 
      (mBDNF) and its precursor proBDNF are associated with autism spectrum disorders 
      (ASD). Whether their levels are different between ASD and intellectual disability 
      (ID) subjects is not clear. The aim of this study is to compare the serum mBDNF 
      and proBDNF concentration, and mBNDF/proBDNF ratio in ASD and ID volunteers. 
      METHODS: Children and adolescents with ASD or ID between the ages of 4 and 22 
      were recruited in Tianjin, China. Serum mBDNF and proBDNF level were tested and 
      Wechsler Preschool and Primary Scale of Intelligence (WPPSI), Wechsler 
      Intelligence Scale for Children (WISC), and Childhood Autism Rating Scale (CARS) 
      evaluations were conducted. RESULTS: Serum mBDNF concentration and the ratio of 
      mBDNF to proBDNF was higher in ASD subjects than that in ID subjects (P = 0.035 
      and P < 0.001, respectively), while serum proBDNF of ASD participants was lower 
      compared to that of ID participants (P < 0.001). CARS score was positively 
      correlated with serum mBDNF level (r = 0.33, P = 0.004) and m/p ratio (r = 0.39, 
      P < 0.001), and negatively correlated with serum proBDNF level (r = -0.39, 
      <0.001) after adjusting for age and IQ. The AUC of mBDNF, proBDNF, and m/p ratio 
      were 0.741, 0.790, and 0.854, respectively, after adjusted for age and IQ. 
      CONCLUSION: Serum mBDNF, proBDNF and m/p ratio were different between ASD and ID 
      group. The three biomarkers displayed good diagnostic values for classification 
      of ASD and ID subjects.
CI  - Copyright (c) 2024 Elsevier Ltd. All rights reserved.
FAU - Cui, Tingkai
AU  - Cui T
AD  - Department of Maternal, Child and Adolescent Health, School of Public Health, 
      Tianjin Medical University, No. 22 Qixiangtai Road, Heping District, Tianjin, 
      300070, China; Tianjin Key Laboratory of Environment, Nutrition and Public 
      Health, School of Public Health, Tianjin Medical University, Tianjin, China.
FAU - Liu, Zhao
AU  - Liu Z
AD  - Department of Maternal, Child and Adolescent Health, School of Public Health, 
      Tianjin Medical University, No. 22 Qixiangtai Road, Heping District, Tianjin, 
      300070, China; Tianjin Key Laboratory of Environment, Nutrition and Public 
      Health, School of Public Health, Tianjin Medical University, Tianjin, China.
FAU - Li, Zhi
AU  - Li Z
AD  - Department of Maternal, Child and Adolescent Health, School of Public Health, 
      Tianjin Medical University, No. 22 Qixiangtai Road, Heping District, Tianjin, 
      300070, China; Tianjin Key Laboratory of Environment, Nutrition and Public 
      Health, School of Public Health, Tianjin Medical University, Tianjin, China.
FAU - Han, Yu
AU  - Han Y
AD  - Department of Maternal, Child and Adolescent Health, School of Public Health, 
      Tianjin Medical University, No. 22 Qixiangtai Road, Heping District, Tianjin, 
      300070, China; Tianjin Key Laboratory of Environment, Nutrition and Public 
      Health, School of Public Health, Tianjin Medical University, Tianjin, China.
FAU - Xiong, Wenjuan
AU  - Xiong W
AD  - Department of Maternal, Child and Adolescent Health, School of Public Health, 
      Tianjin Medical University, No. 22 Qixiangtai Road, Heping District, Tianjin, 
      300070, China; Tianjin Key Laboratory of Environment, Nutrition and Public 
      Health, School of Public Health, Tianjin Medical University, Tianjin, China.
FAU - Qu, Zhiyi
AU  - Qu Z
AD  - Department of Maternal, Child and Adolescent Health, School of Public Health, 
      Tianjin Medical University, No. 22 Qixiangtai Road, Heping District, Tianjin, 
      300070, China; Tianjin Key Laboratory of Environment, Nutrition and Public 
      Health, School of Public Health, Tianjin Medical University, Tianjin, China.
FAU - Zhang, Xin
AU  - Zhang X
AD  - Department of Maternal, Child and Adolescent Health, School of Public Health, 
      Tianjin Medical University, No. 22 Qixiangtai Road, Heping District, Tianjin, 
      300070, China; Tianjin Key Laboratory of Environment, Nutrition and Public 
      Health, School of Public Health, Tianjin Medical University, Tianjin, China. 
      Electronic address: zhangxin@tmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20240104
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Humans
MH  - Adolescent
MH  - Young Adult
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor
MH  - *Autism Spectrum Disorder
MH  - *Intellectual Disability
MH  - China
OTO - NOTNLM
OT  - Autism
OT  - Brain-derived neurotrophic factor
OT  - Intellectual disability
OT  - Serum
COIS- Declaration of competing interest The authors declare that they have no conflict 
      of interest.
EDAT- 2024/01/13 00:41
MHDA- 2024/02/02 06:43
CRDT- 2024/01/12 18:11
PHST- 2023/09/05 00:00 [received]
PHST- 2023/11/09 00:00 [revised]
PHST- 2024/01/02 00:00 [accepted]
PHST- 2024/02/02 06:43 [medline]
PHST- 2024/01/13 00:41 [pubmed]
PHST- 2024/01/12 18:11 [entrez]
AID - S0022-3956(24)00001-3 [pii]
AID - 10.1016/j.jpsychires.2024.01.001 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2024 Feb;170:355-360. doi: 10.1016/j.jpsychires.2024.01.001. 
      Epub 2024 Jan 4.