PMID- 38217028
OWN - NLM
STAT- MEDLINE
DCOM- 20240427
LR  - 20240427
IS  - 1365-4632 (Electronic)
IS  - 0011-9059 (Linking)
VI  - 63
IP  - 5
DP  - 2024 May
TI  - Bullous pemphigoid and diabetes mellitus: a systematic review and meta-analysis.
PG  - 572-579
LID - 10.1111/ijd.16970 [doi]
AB  - We aimed to systematically review and meta-analyze the association between 
      diabetes mellitus (DM) and bullous pemphigoid (BP). Bullous pemphigoid (BP) is a 
      prevalent autoimmune subepidermal blistering disease. Comorbid health conditions 
      like neurological diseases and malignancies have been associated with BP. Growing 
      evidence suggests that type 2 diabetes mellitus (T2DM) may increase the risk of 
      developing BP. This review aims to synthesize this evidence. A systematic 
      literature review was performed using Medline, PubMed, and Scopus in March 2022. 
      Studies exploring the association between BP and DM were included. Data were 
      extracted, and quality was assessed using the Newcastle-Ottawa scale. 
      Meta-analysis was conducted to identify the odds ratio (OR) and 95% confidence 
      intervals (CI) of the association. Seventeen studies were included, most being 
      case-control studies from Europe and Asia. The pooled OR was 2.06 (95% CI: 
      1.61-2.62), suggesting a significant association between DM and BP. However, 
      strong heterogeneity (I(2) = 88%) was observed. Evidence consolidates a 
      significant relationship between DM and BP, potentially due to alterations in the 
      immune system and skin properties caused by diabetes. Strengths of this review 
      include a comprehensive search, rigorous methodology, large sample size, and 
      heterogeneity evaluation. However, varying study quality, potential publication 
      bias, and unaccounted confounding factors present limitations. There is a 
      potential link between T2DM and an increased risk of BP. Further studies are 
      required to understand this association and the underlying mechanisms.
CI  - (c) 2024 the International Society of Dermatology.
FAU - Jiirasutat, Nuttapatch
AU  - Jiirasutat N
AUID- ORCID: 0000-0002-1971-0999
AD  - Dermatology, Thammasat University Hospital, Khlong Nueng, Pathumthani, Thailand.
FAU - Pongchareon, Padcha
AU  - Pongchareon P
AD  - Dermatology, Thammasat University Hospital, Khlong Nueng, Pathumthani, Thailand.
FAU - Weschawalit, Sinee
AU  - Weschawalit S
AD  - Dermatology, Thammasat University Hospital, Khlong Nueng, Pathumthani, Thailand.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20240112
PL  - England
TA  - Int J Dermatol
JT  - International journal of dermatology
JID - 0243704
SB  - IM
MH  - *Pemphigoid, Bullous/epidemiology/complications/immunology
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/epidemiology/complications
MH  - Risk Factors
MH  - Comorbidity
EDAT- 2024/01/13 00:42
MHDA- 2024/04/27 09:54
CRDT- 2024/01/12 23:43
PHST- 2023/11/19 00:00 [revised]
PHST- 2023/09/18 00:00 [received]
PHST- 2023/11/29 00:00 [accepted]
PHST- 2024/04/27 09:54 [medline]
PHST- 2024/01/13 00:42 [pubmed]
PHST- 2024/01/12 23:43 [entrez]
AID - 10.1111/ijd.16970 [doi]
PST - ppublish
SO  - Int J Dermatol. 2024 May;63(5):572-579. doi: 10.1111/ijd.16970. Epub 2024 Jan 12.