PMID- 38218082
OWN - NLM
STAT- MEDLINE
DCOM- 20240214
LR  - 20240214
IS  - 1872-6232 (Electronic)
IS  - 0378-3782 (Linking)
VI  - 189
DP  - 2024 Feb
TI  - Early red blood cell transfusion and the occurrence of intraventricular 
      hemorrhage in very preterm infants.
PG  - 105926
LID - S0378-3782(23)00222-0 [pii]
LID - 10.1016/j.earlhumdev.2023.105926 [doi]
AB  - BACKGROUND: Preterm infants are at risk of developing both intraventricular 
      hemorrhage (IVH) and anemia of prematurity. Several studies reported an 
      association between early postnatal red blood cell (RBC) transfusion and IVH, 
      however the timing and causality between these two remains unclear. AIMS: To 
      describe the temporal sequence between administration of early RBC transfusion 
      (within the first week of life) and diagnosis of IVH in very preterm infants. 
      STUDY DESIGN: Retrospective single center case-series. SUBJECTS: 132 very preterm 
      infants (<32 weeks' gestation), admitted to a level III neonatal intensive care 
      unit, studied with serial cranial ultrasound (CUS), and diagnosed with any grade 
      of IVH. OUTCOME MEASURES: Number and timing of early RBC transfusions in relation 
      to the timing of IVH. RESULTS: Median time of IVH diagnosis was 20.5 h after 
      birth (interquartile range [IQR], 6.25-49.00 h). Of those who received an early 
      RBC transfusion (36 %, 47/132), only 15 % (20/132) received it before the IVH 
      diagnosis. Infants with RBC transfusion before IVH more frequently had lower 
      birth weight, received less fequently antenatal steroids, required more often 
      invasive mechanical ventilation and surfactant administration, had more often 
      hypo- and hypercapnia, and received more fluid boluses, NaHCO3, and inotropes 
      compared to the rest. CONCLUSIONS: In the majority of infants, IVH was already 
      present at the time of the first RBC transfusion. Studies including pre- and post 
      RBC transfusion CUS are needed to assess the effect of early RBC transfusions on 
      the development of IVH in preterm neonates.
CI  - Copyright (c) 2024 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Skubisz, Aleksandra
AU  - Skubisz A
AD  - Student Scientific Association of Neonatology, Institute of Medical Sciences, 
      Medical College of Rzeszow University, University of Rzeszow, Rzeszow, Poland; 
      Willem-Alexander Children's Hospital, Department of Pediatrics, Division of 
      Neonatology, Leiden University Medical Center, Leiden, the Netherlands.
FAU - de Vries, Linda S
AU  - de Vries LS
AD  - Willem-Alexander Children's Hospital, Department of Pediatrics, Division of 
      Neonatology, Leiden University Medical Center, Leiden, the Netherlands.
FAU - Jansen, Sophie J
AU  - Jansen SJ
AD  - Willem-Alexander Children's Hospital, Department of Pediatrics, Division of 
      Neonatology, Leiden University Medical Center, Leiden, the Netherlands.
FAU - van der Staaij, Hilde
AU  - van der Staaij H
AD  - Willem-Alexander Children's Hospital, Department of Pediatrics, Division of 
      Neonatology, Leiden University Medical Center, Leiden, the Netherlands; Sanquin 
      Research & LAB Services, Sanquin Blood Supply Foundation, Amsterdam, the 
      Netherlands.
FAU - Lopriore, Enrico
AU  - Lopriore E
AD  - Willem-Alexander Children's Hospital, Department of Pediatrics, Division of 
      Neonatology, Leiden University Medical Center, Leiden, the Netherlands.
FAU - Steggerda, Sylke J
AU  - Steggerda SJ
AD  - Willem-Alexander Children's Hospital, Department of Pediatrics, Division of 
      Neonatology, Leiden University Medical Center, Leiden, the Netherlands. 
      Electronic address: s.j.steggerda@lumc.nl.
LA  - eng
PT  - Journal Article
DEP - 20240104
PL  - Ireland
TA  - Early Hum Dev
JT  - Early human development
JID - 7708381
SB  - IM
MH  - Infant
MH  - Infant, Newborn
MH  - Humans
MH  - Female
MH  - Pregnancy
MH  - *Infant, Premature
MH  - Erythrocyte Transfusion/adverse effects
MH  - Retrospective Studies
MH  - Infant, Very Low Birth Weight
MH  - *Infant, Premature, Diseases/epidemiology/etiology/therapy
MH  - Cerebral Hemorrhage/diagnostic imaging/epidemiology/etiology
OTO - NOTNLM
OT  - Infant
OT  - Intraventricular hemorrhage
OT  - Premature
OT  - Red blood cell transfusion
COIS- Declaration of competing interest None.
EDAT- 2024/01/14 12:42
MHDA- 2024/02/08 18:42
CRDT- 2024/01/13 18:14
PHST- 2023/11/07 00:00 [received]
PHST- 2023/12/25 00:00 [revised]
PHST- 2023/12/27 00:00 [accepted]
PHST- 2024/02/08 18:42 [medline]
PHST- 2024/01/14 12:42 [pubmed]
PHST- 2024/01/13 18:14 [entrez]
AID - S0378-3782(23)00222-0 [pii]
AID - 10.1016/j.earlhumdev.2023.105926 [doi]
PST - ppublish
SO  - Early Hum Dev. 2024 Feb;189:105926. doi: 10.1016/j.earlhumdev.2023.105926. Epub 
      2024 Jan 4.