PMID- 38218232
OWN - NLM
STAT- MEDLINE
DCOM- 20240214
LR  - 20240214
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 351
DP  - 2024 Mar
TI  - Associations of chronic exposure to a mixture of pesticides and type 2 diabetes 
      mellitus in a Chinese elderly population.
PG  - 141194
LID - S0045-6535(24)00087-0 [pii]
LID - 10.1016/j.chemosphere.2024.141194 [doi]
AB  - Epidemiological studies have related exposure to pesticides to increased risk of 
      diabetes. However, few studies have evaluated the health effects of mixed 
      pesticides exposure, especially in an elderly population. Here, we utilized gas 
      chromatography-tandem mass spectrometry to quantify the levels of 39 pesticides 
      in 4 categories in a Chinese elderly population. Then we used general linear 
      models to explore the association between individual pesticide exposure and type 
      2 diabetes mellitus (T2DM). Restricted cubic spline (RCS) models were fitted to 
      identify potential non-linearities between those associations. Furthermore, 
      stratified analysis by gender was conducted to explore the gender-specific 
      associations. Finally, we used weighted quantile sum (WQS) regression, 
      quantile-based g computation (qgcomp), and Bayesian kernel machine regression 
      (BKMR) to evaluate the effects of mixed exposure to 39 pesticides. The results 
      showed that exposure to pesticides was associated with high risk of T2DM, with 
      beta-Hexachlorocyclohexane (beta-BHC) and oxadiazon being the most significant 
      independent contributors, which was pronounced among elderly women. Moreover, the 
      association of beta-BHC and oxadiazon with T2DM was linear. These indicated that it 
      is an urgent need to take practical measures to control these harmful pesticides.
CI  - Copyright (c) 2024 Elsevier Ltd. All rights reserved.
FAU - Chen, Tian
AU  - Chen T
AD  - State Environmental Protection Key Laboratory of the Assessment of Effects of 
      Emerging Pollutants on Environmental and Human Health, Shanghai Municipal Center 
      for Disease Control and Prevention, Shanghai, China; Department of Environmental 
      Health, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, 
      China.
FAU - Liu, Xiaohua
AU  - Liu X
AD  - Shanghai Minhang Center for Disease Control and Prevention, Shanghai, China.
FAU - Zhang, Jianghua
AU  - Zhang J
AD  - State Environmental Protection Key Laboratory of the Assessment of Effects of 
      Emerging Pollutants on Environmental and Human Health, Shanghai Municipal Center 
      for Disease Control and Prevention, Shanghai, China; Department of Environmental 
      Health, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, 
      China.
FAU - Wang, Lulu
AU  - Wang L
AD  - Key Laboratory of Environment and Health, Ministry of Education & Ministry of 
      Environmental Protection, and State Key Laboratory of Environmental Health, 
      School of Public Health, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, Hubei, China.
FAU - Su, Jin
AU  - Su J
AD  - State Environmental Protection Key Laboratory of the Assessment of Effects of 
      Emerging Pollutants on Environmental and Human Health, Shanghai Municipal Center 
      for Disease Control and Prevention, Shanghai, China; Department of Environmental 
      Health, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, 
      China.
FAU - Jing, Tao
AU  - Jing T
AD  - Key Laboratory of Environment and Health, Ministry of Education & Ministry of 
      Environmental Protection, and State Key Laboratory of Environmental Health, 
      School of Public Health, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, Hubei, China. Electronic address: jingtao@hust.edu.cn.
FAU - Xiao, Ping
AU  - Xiao P
AD  - State Environmental Protection Key Laboratory of the Assessment of Effects of 
      Emerging Pollutants on Environmental and Human Health, Shanghai Municipal Center 
      for Disease Control and Prevention, Shanghai, China. Electronic address: 
      xiaoping@scdc.sh.cn.
LA  - eng
PT  - Journal Article
DEP - 20240111
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Pesticides)
RN  - YM80ODM9PD (beta-hexachlorocyclohexane)
RN  - 59NEE7PCAB (Hexachlorocyclohexane)
SB  - IM
MH  - Humans
MH  - Female
MH  - Aged
MH  - *Pesticides/analysis
MH  - *Diabetes Mellitus, Type 2/chemically induced/epidemiology
MH  - Bayes Theorem
MH  - Gas Chromatography-Mass Spectrometry
MH  - China/epidemiology
MH  - *Hexachlorocyclohexane
OTO - NOTNLM
OT  - Mixture analysis
OT  - Oxadiazon
OT  - Pesticides
OT  - Type 2 diabetes mellitus
OT  - beta-Hexachlorocyclohexane
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2024/01/14 12:42
MHDA- 2024/02/13 06:45
CRDT- 2024/01/13 19:29
PHST- 2023/09/30 00:00 [received]
PHST- 2024/01/02 00:00 [revised]
PHST- 2024/01/10 00:00 [accepted]
PHST- 2024/02/13 06:45 [medline]
PHST- 2024/01/14 12:42 [pubmed]
PHST- 2024/01/13 19:29 [entrez]
AID - S0045-6535(24)00087-0 [pii]
AID - 10.1016/j.chemosphere.2024.141194 [doi]
PST - ppublish
SO  - Chemosphere. 2024 Mar;351:141194. doi: 10.1016/j.chemosphere.2024.141194. Epub 
      2024 Jan 11.