PMID- 38218955 OWN - NLM STAT- MEDLINE DCOM- 20240115 LR - 20240116 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 14 IP - 1 DP - 2024 Jan 13 TI - Association between serum heavy metal levels and diabetic retinopathy in NHANES 2011-2020. PG - 1268 LID - 10.1038/s41598-024-51749-6 [doi] LID - 1268 AB - The present study utilized the National Health and Nutrition Examination Survey (NHANES) database to examine the relationship between serum levels of heavy metals and Diabetic retinopathy (DR) in individuals aged over 30 years with type 2 diabetes mellitus (T2DM) in the United States. A cross-sectional analysis was conducted on 1583 individuals with T2DM from the NHANES 2011-2020, including 331 individuals in the DR group and 1252 individuals in the non-DR group. We collected data on serum levels of heavy metals, DR, and serum albumin for descriptive statistics, linear regression, and logistical regression analysis. After adjusting for age, gender, race and other factors, there was no statistically significant association between blood cadmium, selenium, mercury, or lead and DR. However, serum manganese (Mn) and DR had a significant negative association (beta = - 0.2045, 95% CI = - 0.3484, - 0.0606). Serum albumin partially modulated the indirect influence of serum Mn on the incidence of DR, accounting for 12.80% of the association between serum Mn and DR. There was a negative association between serum Mn levels and the prevalence of DR in people with T2DM. Mn intake at least in this study has a little influence on the onset and development of DR. CI - (c) 2024. The Author(s). FAU - Zhang, Yan AU - Zhang Y AD - The Xuzhou Clinical College of Xuzhou Medical University, Xuzhou, Jiangsu, China. FAU - Liu, Xuekui AU - Liu X AD - Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Xuzhou, Jiangsu, China. FAU - Zhang, Xia AU - Zhang X AD - The Xuzhou Clinical College of Xuzhou Medical University, Xuzhou, Jiangsu, China. FAU - Li, Lin AU - Li L AD - Bengbu Medical College, Bengbu, Anhui, China. FAU - Li, Qing AU - Li Q AD - The Xuzhou Clinical College of Xuzhou Medical University, Xuzhou, Jiangsu, China. FAU - Geng, Houfa AU - Geng H AD - Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Xuzhou, Jiangsu, China. FAU - Shi, Li AU - Shi L AD - Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Xuzhou, Jiangsu, China. FAU - Wang, Ben AU - Wang B AD - Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Xuzhou, Jiangsu, China. FAU - Qiu, Qinqin AU - Qiu Q AD - Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Xuzhou, Jiangsu, China. FAU - Yu, Tianpei AU - Yu T AD - Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Xuzhou, Jiangsu, China. FAU - Sang, Yiquan AU - Sang Y AD - Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Xuzhou, Jiangsu, China. FAU - Wang, Liying AU - Wang L AD - Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Xuzhou, Jiangsu, China. FAU - Liang, Jun AU - Liang J AD - The Xuzhou Clinical College of Xuzhou Medical University, Xuzhou, Jiangsu, China. mwlj521@njmu.edu.cn. AD - Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Xuzhou, Jiangsu, China. mwlj521@njmu.edu.cn. FAU - Xu, Wei AU - Xu W AD - The Xuzhou Clinical College of Xuzhou Medical University, Xuzhou, Jiangsu, China. weixu159357@njmu.edu.cn. AD - Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Xuzhou, Jiangsu, China. weixu159357@njmu.edu.cn. LA - eng GR - 2021-N-03/China International Medical Exchange Foundation Endocrinology and Metabolism Elite Research Fund/ GR - NSFC-81870534/National Nature Science Foundation of China/ GR - XYFZ2020008/Xuzhou Medical University Affiliated Hospital Development Fund/ PT - Journal Article DEP - 20240113 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (Metals, Heavy) RN - 0 (Serum Albumin) SB - IM MH - Humans MH - United States/epidemiology MH - Adult MH - *Diabetes Mellitus, Type 2/complications/epidemiology MH - Nutrition Surveys MH - *Diabetic Retinopathy/etiology MH - Cross-Sectional Studies MH - *Metals, Heavy MH - Serum Albumin PMC - PMC10787836 COIS- The authors declare no competing interests. EDAT- 2024/01/14 12:42 MHDA- 2024/01/15 12:42 PMCR- 2024/01/13 CRDT- 2024/01/13 23:23 PHST- 2023/08/17 00:00 [received] PHST- 2024/01/09 00:00 [accepted] PHST- 2024/01/15 12:42 [medline] PHST- 2024/01/14 12:42 [pubmed] PHST- 2024/01/13 23:23 [entrez] PHST- 2024/01/13 00:00 [pmc-release] AID - 10.1038/s41598-024-51749-6 [pii] AID - 51749 [pii] AID - 10.1038/s41598-024-51749-6 [doi] PST - epublish SO - Sci Rep. 2024 Jan 13;14(1):1268. doi: 10.1038/s41598-024-51749-6.