PMID- 38221565
OWN - NLM
STAT- Publisher
LR  - 20240114
IS  - 1993-0402 (Electronic)
IS  - 1672-0415 (Linking)
DP  - 2024 Jan 15
TI  - Efficacy and Safety of Chinese Medicine Resuscitation Pack for Enhanced Recovery 
      after Bronchoscopy: A Randomized, Single-Blind, Placebo-Controlled Clinical 
      Trial.
LID - 10.1007/s11655-024-3569-z [doi]
AB  - OBJECTIVE: To evaluate the efficacy and safety of a hospital-made resuscitation 
      pack, a Chinese medicinal herbal compound formula designed to enhance recovery in 
      post-bronchoscopy patients. METHODS: In this randomized, single-blind, 
      placebo-controlled clinical trial, eligible patients were randomly assigned 1:1 
      to either the treatment or control groups. The patients in the treatment group 
      applied the resuscitation pack, which contained aromatic compounded Chinese 
      herbs. The patients in the control group applied a hospital-made, single herb 
      placebo pack. Packs were placed on the Tiantu (CV 22) acupuncture point for 4 h 
      as soon as the bronchoscopy finished. Efficacy indicators, such as recovery time, 
      patients' symptoms including nausea and dizziness, and adverse events (AEs) were 
      observed and compared. The outcome indices were evaluated at baseline, 1 and 24 h 
      after the bronchoscopy. Subgroup analysis was further performed by patients' age 
      and depth of sedation. RESULTS: When applying generalized estimating equations 
      (GEE) to evaluate the intensity of post-bronchoscopy nausea and vomiting, the 
      intensity was lower in the treatment group (163 cases) compared with the control 
      group (162 cases; 95% CI: 0.004, 0.099, P=0.03]. Also, significantly lower 
      intensity of nausea was observed in the 60-70 years of age subgroup (95% CI: 
      0.029, 0.169, P=0.006) and deep sedation subgroup (95% CI: 0.002, 0.124; P=0.04). 
      There was no significant difference in dizziness between two groups by GEE (95% 
      CI: -0.134, 0.297; P=0.459). In addition, no serious AEs were observed in either 
      group. CONCLUSIONS: Our study found that the resuscitation pack markedly improved 
      patients' symptoms by reducing nausea and vomiting after bronchoscopy without 
      AEs, compared with placebo in the perioperative period. (Trial registration No. 
      ChiCTR2000038299).
CI  - (c) 2024. The Chinese Journal of Integrated Traditional and Western Medicine Press 
      and Springer-Verlag GmbH Germany, part of Springer Nature.
FAU - Tan, Xin-Yuan
AU  - Tan XY
AD  - Department of Pulmonary and Critical Care Medicine, Guangdong Provincial Hospital 
      of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, 
      Guangzhou, 510120, China.
FAU - Yao, Yao
AU  - Yao Y
AD  - Department of Pulmonary and Critical Care Medicine, Guangdong Provincial Hospital 
      of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, 
      Guangzhou, 510120, China.
FAU - Xiao, Jing-Min
AU  - Xiao JM
AD  - Chronic Respiratory Disease and Chinese Medicine Research Team, Guangdong 
      Provincial Academy of Chinese Medical Sciences, Guangzhou, 510120, China.
FAU - Chen, Yuan-Bin
AU  - Chen YB
AD  - Chronic Respiratory Disease and Chinese Medicine Research Team, Guangdong 
      Provincial Academy of Chinese Medical Sciences, Guangzhou, 510120, China.
FAU - Lin, Ming
AU  - Lin M
AD  - Department of Pulmonary and Critical Care Medicine, Guangdong Provincial Hospital 
      of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, 
      Guangzhou, 510120, China.
FAU - Zhang, Xiao-Shan
AU  - Zhang XS
AD  - Department of Pulmonary and Critical Care Medicine, Guangdong Provincial Hospital 
      of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, 
      Guangzhou, 510120, China.
FAU - Cai, Dan-Yan
AU  - Cai DY
AD  - Department of Pulmonary and Critical Care Medicine, Guangdong Provincial Hospital 
      of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, 
      Guangzhou, 510120, China.
FAU - Wu, Zhen-Hu
AU  - Wu ZH
AD  - Department of Pulmonary and Critical Care Medicine, Guangdong Provincial Hospital 
      of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, 
      Guangzhou, 510120, China.
FAU - Sun, Li-Li
AU  - Sun LL
AD  - The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, 
      510006, China.
FAU - Fan, Fei-Ting
AU  - Fan FT
AD  - Chronic Respiratory Disease and Chinese Medicine Research Team, Guangdong 
      Provincial Academy of Chinese Medical Sciences, Guangzhou, 510120, China.
FAU - Xu, Yin-Ji
AU  - Xu YJ
AD  - Department of Pulmonary and Critical Care Medicine, Guangdong Provincial Hospital 
      of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, 
      Guangzhou, 510120, China. xuyinji@gzucm.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20240115
PL  - China
TA  - Chin J Integr Med
JT  - Chinese journal of integrative medicine
JID - 101181180
SB  - IM
OTO - NOTNLM
OT  - Chinese medicine
OT  - aromatherapy
OT  - bronchoscopy
OT  - enhanced recovery
OT  - placebo-controlled trial
OT  - randomized
EDAT- 2024/01/15 00:42
MHDA- 2024/01/15 00:42
CRDT- 2024/01/14 23:06
PHST- 2023/09/08 00:00 [accepted]
PHST- 2024/01/15 00:42 [medline]
PHST- 2024/01/15 00:42 [pubmed]
PHST- 2024/01/14 23:06 [entrez]
AID - 10.1007/s11655-024-3569-z [pii]
AID - 10.1007/s11655-024-3569-z [doi]
PST - aheadofprint
SO  - Chin J Integr Med. 2024 Jan 15. doi: 10.1007/s11655-024-3569-z.