PMID- 38222031
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240116
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 17
DP  - 2024
TI  - Association of Uric Acid to Creatinine Ratio with Metabolic 
      Dysfunction-Associated Fatty Liver in Non-Obese Individuals Without Type 2 
      Diabetes Mellitus.
PG  - 131-142
LID - 10.2147/DMSO.S445916 [doi]
AB  - INTRODUCTION: Metabolic dysfunction-associated fatty liver disease (MAFLD) is the 
      most common chronic liver disease, which is usually associated with type 2 
      diabetes mellitus (T(2)DM) and obesity. However, the incidence of MALFD in 
      non-obese individuals without T(2)DM is increasing, and the pathogenesis is 
      unclear. Serum uric acid to creatinine ratio (sUA/Cr) can reflect overall 
      metabolic status. This study aims to observe the association between sUA/Cr and 
      MAFLD in non-obese individuals without T(2)DM. METHODS: A total of 21,996 
      individuals were included in this study. The subjects were divided into four 
      subgroups: non-obese patients without T(2)DM, obese patients without T(2)DM, 
      non-obese patients with T(2)DM, and obese patients with T(2)DM. Logistic 
      regression analyzed the correlation between sUA/Cr and MAFLD subgroups. Receiver 
      operating characteristics analyzed the predictive value of sUA/Cr for MAFLD 
      subgroups. The stratified analyses by sex and age were performed. RESULTS: 
      Non-obese MAFLD individuals without T(2)DM had higher sUA/Cr levels than their 
      counterparts. sUA/Cr was significantly correlated positively with MAFLD in 
      non-obese patients. Similar results were observed in both males and females and 
      in populations at all age stages (all p<0.01). sUA/Cr was capable of 
      discriminating MAFLD in non-obese individuals without T(2)DM (AUC: 0.667), 
      especially for patients over 60 years old (AUC: 0.704). CONCLUSION: The sUA/Cr 
      ratio was correlated with MAFLD in non-obese patients without T(2)DM. The 
      predictive value of sUA/Cr for MAFLD was observed. Hence, the sUA/Cr ratio might 
      be given more concern for the risk of MAFLD in non-obese individuals without 
      T(2)DM.
CI  - (c) 2024 Liu et al.
FAU - Liu, Jing
AU  - Liu J
AD  - China-Japan Friendship Hospital, Chinese Academy of Medical Sciences & Peking 
      Union Medical College, Beijing, People's Republic of China.
FAU - Wang, Che
AU  - Wang C
AUID- ORCID: 0000-0003-4502-3620
AD  - School of Qi Huang, Beijing University of Chinese Medicine, Beijing, People's 
      Republic of China.
FAU - Wang, Yutong
AU  - Wang Y
AUID- ORCID: 0000-0002-5819-3787
AD  - School of Qi Huang, Beijing University of Chinese Medicine, Beijing, People's 
      Republic of China.
FAU - Yao, Shukun
AU  - Yao S
AUID- ORCID: 0000-0002-8512-2589
AD  - Department of Gastroenterology, China-Japan Friendship Hospital, Beijing, 
      People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20240108
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC10786728
OTO - NOTNLM
OT  - creatinine
OT  - metabolic dysfunction-associated fatty liver disease
OT  - non-obesity
OT  - type 2 diabetes mellitus
OT  - uric acid
COIS- The authors have no relevant financial or non-financial interests to disclose.
EDAT- 2024/01/15 06:42
MHDA- 2024/01/15 06:43
PMCR- 2024/01/08
CRDT- 2024/01/15 04:27
PHST- 2023/10/21 00:00 [received]
PHST- 2023/12/28 00:00 [accepted]
PHST- 2024/01/15 06:43 [medline]
PHST- 2024/01/15 06:42 [pubmed]
PHST- 2024/01/15 04:27 [entrez]
PHST- 2024/01/08 00:00 [pmc-release]
AID - 445916 [pii]
AID - 10.2147/DMSO.S445916 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2024 Jan 8;17:131-142. doi: 10.2147/DMSO.S445916. 
      eCollection 2024.