PMID- 3822241
OWN - NLM
STAT- MEDLINE
DCOM- 19870408
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 72
IP  - 3
DP  - 1986 Dec 23
TI  - Reduction of the volume of the sexually dimorphic nucleus of the preoptic area by 
      in utero ethanol exposure in male rats.
PG  - 363-8
AB  - Ethanol consumption during pregnancy has been demonstrated to result in 
      alterations in central nervous system structure and function. Albino female rats 
      were given either a liquid diet containing ethanol (5% w/v), a liquid diet which 
      contained maltose-dextrin substituted isocalorically for the alcohol, or 
      laboratory chow and water throughout pregnancy and for 14 days following birth. 
      The volumes of the sexually dimorphic nucleus of the preoptic area (SDN-POA) and 
      the nucleus accumbens septi (ACN) were measured in adult male rats exposed in 
      utero and postnatally to these diets. Adult male rats exposed to ethanol in utero 
      exhibit significantly smaller SDN-POA volumes (P less than 0.02) when compared to 
      those of animals which received the control diets during the gestational period 
      and postnatally. Ethanol treatment did not significantly influence the volume of 
      the ACN. The results indicate that maternal ethanol consumption during pregnancy 
      retards or inhibits SDN-POA development in fetal ethanol exposed male rats when 
      compared to the nuclear volume in rats whose mothers were not exposed to ethanol 
      during pregnancy.
FAU - Rudeen, P K
AU  - Rudeen PK
LA  - eng
GR  - NIAAA 05893/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Ethanol/*toxicity
MH  - Female
MH  - Male
MH  - *Maternal-Fetal Exchange
MH  - Nucleus Accumbens/drug effects
MH  - Pregnancy
MH  - Preoptic Area/*drug effects
MH  - Rats
MH  - Rats, Inbred Strains
MH  - *Sex Characteristics
EDAT- 1986/12/23 00:00
MHDA- 1986/12/23 00:01
CRDT- 1986/12/23 00:00
PHST- 1986/12/23 00:00 [pubmed]
PHST- 1986/12/23 00:01 [medline]
PHST- 1986/12/23 00:00 [entrez]
AID - 0304-3940(86)90542-2 [pii]
AID - 10.1016/0304-3940(86)90542-2 [doi]
PST - ppublish
SO  - Neurosci Lett. 1986 Dec 23;72(3):363-8. doi: 10.1016/0304-3940(86)90542-2.