PMID- 38222790
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240116
IS  - 1948-9358 (Print)
IS  - 1948-9358 (Electronic)
IS  - 1948-9358 (Linking)
VI  - 14
IP  - 12
DP  - 2023 Dec 15
TI  - Comparative study of type 2 diabetes mellitus-associated gut microbiota between 
      the Dai and Han populations.
PG  - 1766-1783
LID - 10.4239/wjd.v14.i12.1766 [doi]
AB  - BACKGROUND: The global prevalence of type 2 diabetes mellitus (T2DM) is 
      increasing. T2DM is associated with alterations of the gut microbiota, which can 
      be affected by age, illness, and genetics. Previous studies revealed that there 
      are discriminating microbiota compositions between the Dai and the Han 
      populations. However, the specific gut microbiota differences between the two 
      populations have not been elucidated. AIM: To compare the gut microbiota 
      differences in subjects with and without T2DM in the Dai and Han populations. 
      METHODS: A total of 35 subjects of the Han population (including 15 healthy 
      children, 8 adult healthy controls, and 12 adult T2DM patients) and 32 subjects 
      of the Dai population (including 10 healthy children, 10 adult healthy controls, 
      and 12 adult T2DM patients) were enrolled in this study. Fasting venous blood 
      samples were collected from all the subjects for biochemical analysis. Fecal 
      samples were collected from all the subjects for DNA extraction and 16S rRNA 
      sequencing, which was followed by analyses of the gut microbiota composition. 
      RESULTS: No significant difference in alpha diversity was observed between 
      healthy children and adults. The diversity of gut microbiota was decreased in 
      T2DM patients compared to the healthy adults in both the Dai and Han populations. 
      There was a significant difference in gut microbiota between healthy children and 
      healthy adults in the Han population with an increased abundance of Bacteroidetes 
      and decreased Firmicutes in children. However, this difference was less in the 
      Dai population. Significant increases in Bacteroidetes in the Han population and 
      Proteobacteria in the Dai population and decreases in Firmicutes in both the Han 
      and Dai population were observed in T2DM patients compared to healthy adults. 
      Linear discriminant analysis Effect Size analysis also showed that the gut 
      microbiota was different between the Han and Dai populations in heathy children, 
      adults, and T2DM patients. Four bacteria were consistently increased and two 
      consistently decreased in the Han population compared to the Dai population. 
      CONCLUSION: Differences in gut microbiota were found between the Han and Dai 
      populations. A significant increase in Bacteroidetes was related to the 
      occurrence of T2DM in the Han population, while a significant increase in 
      Proteobacteria was related to the occurrence of T2DM in the Dai population.
CI  - (c)The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Tang, Ling-Tong
AU  - Tang LT
AD  - Department of Clinical Laboratory, Yan'an Hospital Affiliated to Kunming Medical 
      University, Kunming 650051, Yunnan Province, China.
FAU - Feng, Lei
AU  - Feng L
AD  - Department of Clinical Laboratory, Yan'an Hospital Affiliated to Kunming Medical 
      University, Kunming 650051, Yunnan Province, China. fngj2004@163.com.
FAU - Cao, Hui-Ying
AU  - Cao HY
AD  - Department of Clinical Laboratory, Yan'an Hospital Affiliated to Kunming Medical 
      University, Kunming 650051, Yunnan Province, China.
FAU - Shi, Rui
AU  - Shi R
AD  - Department of Clinical Laboratory, Sixth Affiliated Hospital of Kunming Medical 
      University, Kunming 650051, Yunnan Province, China.
FAU - Luo, Bei-Bei
AU  - Luo BB
AD  - Department of Clinical Laboratory, Sixth Affiliated Hospital of Kunming Medical 
      University, Kunming 650051, Yunnan Province, China.
FAU - Zhang, Yan-Bi
AU  - Zhang YB
AD  - Department of Clinical Laboratory, Sixth Affiliated Hospital of Kunming Medical 
      University, Kunming 650051, Yunnan Province, China.
FAU - Liu, Yan-Mei
AU  - Liu YM
AD  - Department of Clinical Laboratory, Yan'an Hospital Affiliated to Kunming Medical 
      University, Kunming 650051, Yunnan Province, China.
FAU - Zhang, Jian
AU  - Zhang J
AD  - Department of Clinical Laboratory, Yan'an Hospital Affiliated to Kunming Medical 
      University, Kunming 650051, Yunnan Province, China.
FAU - Li, Shuang-Yue
AU  - Li SY
AD  - Department of Clinical Laboratory, Yan'an Hospital Affiliated to Kunming Medical 
      University, Kunming 650051, Yunnan Province, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Diabetes
JT  - World journal of diabetes
JID - 101547524
PMC - PMC10784794
OTO - NOTNLM
OT  - Dai population
OT  - Ethnic
OT  - Genetics
OT  - Gut microbiota
OT  - Han population
OT  - Type 2 diabetes mellitus
COIS- Conflict-of-interest statement: All the authors report no relevant conflicts of 
      interest for this article.
EDAT- 2024/01/15 06:43
MHDA- 2024/01/15 06:44
PMCR- 2023/12/15
CRDT- 2024/01/15 04:36
PHST- 2023/10/07 00:00 [received]
PHST- 2023/10/24 00:00 [revised]
PHST- 2023/11/17 00:00 [accepted]
PHST- 2024/01/15 06:44 [medline]
PHST- 2024/01/15 06:43 [pubmed]
PHST- 2024/01/15 04:36 [entrez]
PHST- 2023/12/15 00:00 [pmc-release]
AID - 10.4239/wjd.v14.i12.1766 [doi]
PST - ppublish
SO  - World J Diabetes. 2023 Dec 15;14(12):1766-1783. doi: 10.4239/wjd.v14.i12.1766.