PMID- 3822297
OWN - NLM
STAT- MEDLINE
DCOM- 19870422
LR  - 20091026
IS  - 0029-7844 (Print)
IS  - 0029-7844 (Linking)
VI  - 69
IP  - 4
DP  - 1987 Apr
TI  - Effect of the Today contraceptive sponge on growth and toxic shock syndrome 
      toxin-1 production by Staphylococcus aureus.
PG  - 563-9
AB  - Toxic-shock syndrome toxin-1 (TSST-1)-producing Staphylococcus aureus MN8 was 
      grown in dialyzed beef heart infusion broth, or dialyzed beef heart infusion 
      broth supplemented with 5% human blood or with 5% human semen, in the presence 
      and absence of Today contraceptive sponges. Early growth of the organism was 
      inhibited by the presence of the sponges in aerobic, static aerobic, and 
      anaerobic cultures. In aerobic cultures that contained the sponge, minimal TSST-1 
      was detected by immunodiffusion assay, whereas in control cultures that did not 
      contain the sponge, extensive toxin production was seen. In static and anaerobic 
      cultures, the presence of the contraceptive sponge resulted in toxin levels less 
      than or equal to the low levels seen in control cultures. These results suggest 
      that Today contraceptive sponges may inhibit TSST-1 production by S aureus.
FAU - Remington, K M
AU  - Remington KM
FAU - Buller, R S
AU  - Buller RS
FAU - Kelly, J R
AU  - Kelly JR
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Obstet Gynecol
JT  - Obstetrics and gynecology
JID - 0401101
RN  - 0 (Bacterial Toxins)
RN  - 0 (Culture Media)
RN  - 0 (Enterotoxins)
RN  - 0 (Superantigens)
RN  - 0 (enterotoxin F, Staphylococcal)
SB  - IM
MH  - Aerobiosis
MH  - Anaerobiosis
MH  - Animals
MH  - *Bacterial Toxins
MH  - Cattle
MH  - Contraceptive Devices, Female/*adverse effects
MH  - Culture Media/metabolism
MH  - Depression, Chemical
MH  - Enterotoxins/*biosynthesis
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Male
MH  - Shock, Septic/etiology
MH  - Staphylococcus aureus/drug effects/*growth & development/metabolism
MH  - *Superantigens
EDAT- 1987/04/01 00:00
MHDA- 1987/04/01 00:01
CRDT- 1987/04/01 00:00
PHST- 1987/04/01 00:00 [pubmed]
PHST- 1987/04/01 00:01 [medline]
PHST- 1987/04/01 00:00 [entrez]
PST - ppublish
SO  - Obstet Gynecol. 1987 Apr;69(4):563-9.