PMID- 38223315
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240116
IS  - 2160-1992 (Print)
IS  - 2160-1992 (Electronic)
IS  - 2160-1992 (Linking)
VI  - 13
IP  - 6
DP  - 2023
TI  - A retrospective analysis of the frequency of heparin-induced thrombocytopenia in 
      the intensive care unit at a tertiary care center in Riyadh, Saudi Arabia.
PG  - 198-206
AB  - BACKGROUND: Heparin-induced thrombocytopenia (HIT) is an extremely serious and 
      potentially fatal condition that can develop in patients taking heparin-based 
      medications, such as unfractionated heparin (UFH) or low-molecular-weight heparin 
      (LMWH). The incidence and risk factors for HIT in critically ill patients, 
      however, are not well defined. METHODS: We retrospectively collected data on HIT 
      test results, route of heparin administration, age, sex, heparin type (UFH or 
      LMWH), and date of illness from patients admitted to the intensive care unit 
      (ICU) and regular nursing floor (non-ICU) at our hospital between January 2011 
      and December 2014. We screened patients for HIT using the 4T score and confirmed 
      the diagnosis through laboratory testing (direct enzyme immunoassay 
      immunoglobulin G [IgG] or a platelet-activating antibody). RESULTS: We screened a 
      total of 946 patients, 56 (5.9%) of whom were positive for HIT. Among 776 
      patients receiving UFH and 180 receiving LMWH, 2.8 and 6.6% developed HIT, 
      respectively (P = 0.051). We then classified our patients into two groups: ICU, 
      and non-ICU. In the non-ICU group (n = 317), 4 (2.7%) patients receiving LMWH and 
      25 (5.1%) receiving UFH were positive for HIT (P = 0.221). In the ICU group (n = 
      639), 1 (3.1%) patient receiving LMWH and 26 (9.1%) receiving UFH were positive 
      for HIT (P = 0.249). The ICU group, therefore, had a higher cumulative incidence 
      rate of HIT than the non-ICU group (8.5 vs. 4.5%). CONCLUSION: HIT was more 
      common in ICU patients than non-ICU patients and in more patients receiving UFH 
      than LMWH, although the differences were not statistically significant. Early 
      diagnosis and appropriate treatment are essential to prevent adverse outcomes in 
      patients with HIT.
CI  - AJBR Copyright (c) 2023.
FAU - Mushtaq, Ali H
AU  - Mushtaq AH
AD  - Al Faisal University Riyadh, Saudi Arabia.
AD  - Department of Internal Medicine, Cleveland Clinic Foundation Cleveland, Ohio, The 
      United States of America.
FAU - Rasheed, Abdulrahman W
AU  - Rasheed AW
AD  - Department of Internal Medicine, Cleveland Clinic Foundation Cleveland, Ohio, The 
      United States of America.
FAU - Jamil, Mouhamad G
AU  - Jamil MG
AD  - Department of Hematology, King Faisal Specialist Hospital and Research Center 
      Riyadh, Saudi Arabia.
FAU - Maghrabi, Khalid
AU  - Maghrabi K
AD  - Department of Hematology, King Faisal Specialist Hospital and Research Center 
      Riyadh, Saudi Arabia.
FAU - Khoja, Osama
AU  - Khoja O
AD  - Department of Hematology, King Faisal Specialist Hospital and Research Center 
      Riyadh, Saudi Arabia.
FAU - Sajid, Muhammad R
AU  - Sajid MR
AD  - Al Faisal University Riyadh, Saudi Arabia.
FAU - Tamim, Hani
AU  - Tamim H
AD  - Al Faisal University Riyadh, Saudi Arabia.
FAU - Hijazi, Mohammad
AU  - Hijazi M
AD  - Department of Hematology, King Faisal Specialist Hospital and Research Center 
      Riyadh, Saudi Arabia.
FAU - Owaidah, Tarek
AU  - Owaidah T
AD  - Al Faisal University Riyadh, Saudi Arabia.
AD  - Department of Hematology, King Faisal Specialist Hospital and Research Center 
      Riyadh, Saudi Arabia.
LA  - eng
PT  - Journal Article
DEP - 20231225
PL  - United States
TA  - Am J Blood Res
JT  - American journal of blood research
JID - 101569577
PMC - PMC10784120
OTO - NOTNLM
OT  - Heparin-induced thrombocytopenia
OT  - critical illness
OT  - heparin
OT  - intensive care unit
OT  - low molecular weight heparin
COIS- None.
EDAT- 2024/01/15 06:42
MHDA- 2024/01/15 06:43
PMCR- 2023/12/25
CRDT- 2024/01/15 04:46
PHST- 2023/08/11 00:00 [received]
PHST- 2023/12/21 00:00 [accepted]
PHST- 2024/01/15 06:43 [medline]
PHST- 2024/01/15 06:42 [pubmed]
PHST- 2024/01/15 04:46 [entrez]
PHST- 2023/12/25 00:00 [pmc-release]
AID - 10.62347/GPME5540 [doi]
PST - epublish
SO  - Am J Blood Res. 2023 Dec 25;13(6):198-206. doi: 10.62347/GPME5540. eCollection 
      2023.