PMID- 38223333
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240116
IS  - 2666-9145 (Electronic)
IS  - 2666-9145 (Linking)
VI  - 3
IP  - 4
DP  - 2023 Dec
TI  - Longitudinal Analysis of Retinal Microvascular and Choroidal Imaging Parameters 
      in Parkinson's Disease Compared with Controls.
PG  - 100393
LID - 10.1016/j.xops.2023.100393 [doi]
LID - 100393
AB  - PURPOSE: To quantify rate of change of retinal microvascular and choroidal 
      structural parameters in subjects with Parkinson's disease (PD) compared with 
      controls using OCT and OCT angiography (OCTA). DESIGN: Prospective longitudinal 
      study. PARTICIPANTS: Seventy-four eyes of 40 participants with PD and 149 eyes of 
      78 control individuals from the Eye Multimodal Imaging in Neurodegenerative 
      Disease database. METHODS: Subjects underwent OCT and OCTA imaging at 2 time 
      points approximately 12 months apart. MAIN OUTCOME MEASURES: Imaging parameters 
      included central subfield thickness, ganglion cell-inner plexiform layer (GC-IPL) 
      thickness, peripapillary retinal nerve fiber layer thickness, choroidal 
      vascularity index, superficial capillary plexus perfusion density (PFD), vessel 
      density (VD), and foveal avascular zone area. RESULTS: Participants with PD had 
      greater rate of yearly decrease in GC-IPL (PD = -0.403mum, control = + 0.128 mum; 
      P = 0.01), greater yearly decline in PFD in the 3 x 3 mm ETDRS circle 
      (PD = -0.016, control = + 0.002; P < 0.001) and ring (PD = -0.016, control = + 
      0.002; P < 0.001); 6 x 6 mm ETDRS circle (PD = -0.021, control = 0.00; P = 
      0.001), and outer ring (PD = -0.022, control = 0.00; P = 0.001). Participants 
      with PD had greater rate of yearly decline in VD in 3 x 3 mm circle 
      (PD = -0.939/mm, control = + 0.006/mm; P < 0.001) and ring (PD = -0.942/mm, 
      control = + 0.013/mm; P < 0.001); 6 x 6 mm circle (PD = -0.72/mm, 
      control = -0.054/mm; P = 0.006), and outer ring (PD = -0.746/mm, 
      control = -0.054/mm; P = 0.005). When stratified by PD severity based on Hoehn 
      and Yahr stage, faster rates of decline were seen in Hoehn and Yahr stages 3 to 4 
      in the 3 x 3 mm circle PFD and VD as well as 3 x 3 mm ring VD. CONCLUSIONS: 
      Individuals with PD experience more rapid loss of retinal microvasculature 
      quantified on OCTA and more rapid thinning of the GC-IPL than controls. There may 
      be more rapid loss in patients with greater disease severity. FINANCIAL 
      DISCLOSURES: The author(s) have no proprietary or commercial interest in any 
      materials discussed in this article.
CI  - (c) 2023 by the American Academy of Ophthalmology.
FAU - Kundu, Anita
AU  - Kundu A
AD  - Department of Ophthalmology, Duke University School of Medicine, Durham, North 
      Carolina.
AD  - iMIND Research Group, Durham, North Carolina.
FAU - Ma, Justin P
AU  - Ma JP
AD  - Department of Ophthalmology, Duke University School of Medicine, Durham, North 
      Carolina.
AD  - iMIND Research Group, Durham, North Carolina.
FAU - Robbins, Cason B
AU  - Robbins CB
AD  - Department of Ophthalmology, Duke University School of Medicine, Durham, North 
      Carolina.
AD  - iMIND Research Group, Durham, North Carolina.
FAU - Pant, Praruj
AU  - Pant P
AD  - Department of Ophthalmology, Duke University School of Medicine, Durham, North 
      Carolina.
AD  - iMIND Research Group, Durham, North Carolina.
FAU - Gunasan, Vithiya
AU  - Gunasan V
AD  - National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore.
FAU - Agrawal, Rupesh
AU  - Agrawal R
AD  - National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore.
AD  - Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
FAU - Stinnett, Sandra
AU  - Stinnett S
AD  - Department of Ophthalmology, Duke University School of Medicine, Durham, North 
      Carolina.
AD  - iMIND Research Group, Durham, North Carolina.
FAU - Scott, Burton L
AU  - Scott BL
AD  - iMIND Research Group, Durham, North Carolina.
AD  - Department of Neurology, Duke University School of Medicine, Durham, North 
      Carolina.
FAU - Moore, Kathryn P L
AU  - Moore KPL
AD  - iMIND Research Group, Durham, North Carolina.
AD  - Department of Neurology, Duke University School of Medicine, Durham, North 
      Carolina.
FAU - Fekrat, Sharon
AU  - Fekrat S
AD  - Department of Ophthalmology, Duke University School of Medicine, Durham, North 
      Carolina.
AD  - iMIND Research Group, Durham, North Carolina.
AD  - Department of Neurology, Duke University School of Medicine, Durham, North 
      Carolina.
FAU - Grewal, Dilraj S
AU  - Grewal DS
AD  - Department of Ophthalmology, Duke University School of Medicine, Durham, North 
      Carolina.
AD  - iMIND Research Group, Durham, North Carolina.
LA  - eng
PT  - Journal Article
DEP - 20230909
PL  - Netherlands
TA  - Ophthalmol Sci
JT  - Ophthalmology science
JID - 9918230896206676
PMC - PMC10786668
OTO - NOTNLM
OT  - Biomarker
OT  - Neurodegeneration
OT  - OCTA
OT  - Parkinson's disease
OT  - Retina
EDAT- 2024/01/15 06:42
MHDA- 2024/01/15 06:43
PMCR- 2023/09/09
CRDT- 2024/01/15 04:46
PHST- 2023/02/26 00:00 [received]
PHST- 2023/08/15 00:00 [revised]
PHST- 2023/08/29 00:00 [accepted]
PHST- 2024/01/15 06:43 [medline]
PHST- 2024/01/15 06:42 [pubmed]
PHST- 2024/01/15 04:46 [entrez]
PHST- 2023/09/09 00:00 [pmc-release]
AID - S2666-9145(23)00125-2 [pii]
AID - 100393 [pii]
AID - 10.1016/j.xops.2023.100393 [doi]
PST - epublish
SO  - Ophthalmol Sci. 2023 Sep 9;3(4):100393. doi: 10.1016/j.xops.2023.100393. 
      eCollection 2023 Dec.