PMID- 38223850
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240116
IS  - 2467-981X (Electronic)
IS  - 2467-981X (Linking)
VI  - 9
DP  - 2024
TI  - Effects of sleep deprivation on cortical excitability: A threshold-tracking TMS 
      study and review of the literature.
PG  - 13-20
LID - 10.1016/j.cnp.2023.12.001 [doi]
AB  - OBJECTIVE: Insufficient sleep is linked to several health problems. Previous 
      studies on the effects of sleep deprivation on cortical excitability using 
      conventional transcranial magnetic stimulation (TMS) included a limited number of 
      modalities, and few inter-stimulus intervals (ISIs) and showed conflicting 
      results. This study aimed to investigate the effects of sleep deprivation on 
      cortical excitability through threshold-tracking TMS, using a wide range of 
      protocols at multiple ISIs. METHODS: Fifteen healthy subjects (mean age +/- SD: 
      36 +/- 3.34 years) were included. The following tests were performed before and 
      after 24 h of sleep deprivation using semi-automated threshold-tacking TMS 
      protocols: short-interval intracortical inhibition (SICI) and intracortical 
      facilitation (ICF) at 11 ISIs between 1 and 30 ms, short interval intracortical 
      facilitation (SICF) at 14 ISIs between 1 and 4.9 ms, long interval intracortical 
      inhibition (LICI) at 6 ISIs between 50 and 300 ms, and short-latency afferent 
      inhibition (SAI) at 12 ISIs between 16 and 30 ms. RESULTS: No significant 
      differences were observed between pre- and post-sleep deprivation measurements 
      for SICI, ICF, SICF, or LICI at any ISIs (p < 0.05). As for SAI, we found a 
      difference at 28 ms (p = 0.007) and 30 ms (p = 0.04) but not at other ISIs. 
      CONCLUSIONS: Sleep deprivation does not affect cortical excitability except for 
      SAI. SIGNIFICANCE: This study confirms some of the previous studies while 
      contradicting others.
CI  - (c) 2023 International Federation of Clinical Neurophysiology. Published by 
      Elsevier B.V.
FAU - Mroczek, Magdalena
AU  - Mroczek M
AD  - Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, 
      Denmark.
FAU - de Grado, Amedeo
AU  - de Grado A
AD  - Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, 
      Denmark.
AD  - Neurophysiology Unit, IRCCS Fondazione Istituto Neurologico "Carlo Besta", 
      Universita degli Studi di Milano, Milano, Italy.
FAU - Pia, Hossain
AU  - Pia H
AD  - Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, 
      Denmark.
FAU - Nochi, Zahra
AU  - Nochi Z
AD  - Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, 
      Aarhus, Denmark.
FAU - Tankisi, Hatice
AU  - Tankisi H
AD  - Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, 
      Denmark.
AD  - Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, 
      Denmark.
LA  - eng
PT  - Journal Article
DEP - 20231212
PL  - Netherlands
TA  - Clin Neurophysiol Pract
JT  - Clinical neurophysiology practice
JID - 101684308
PMC - PMC10787222
OTO - NOTNLM
OT  - Intracortical facilitation
OT  - Long-interval intracortical inhibition
OT  - Short-interval intracortical facilitation
OT  - Short-interval intracortical inhibition
OT  - Short-latency afferent inhibition
OT  - Sleep deprivation
OT  - Threshold-tracking transcranial magnetic stimulation
COIS- The authors declare the following financial interests/personal relationships 
      which may be considered as potential competing interests: 'HT is a shareholder of 
      QTMS Science Ltd., which licences the QTMSG-12 recording protocols used. Other 
      authors have no potential conflict of interest to declare'.
EDAT- 2024/01/15 06:43
MHDA- 2024/01/15 06:44
PMCR- 2023/12/12
CRDT- 2024/01/15 04:55
PHST- 2023/08/27 00:00 [received]
PHST- 2023/11/09 00:00 [revised]
PHST- 2023/12/01 00:00 [accepted]
PHST- 2024/01/15 06:44 [medline]
PHST- 2024/01/15 06:43 [pubmed]
PHST- 2024/01/15 04:55 [entrez]
PHST- 2023/12/12 00:00 [pmc-release]
AID - S2467-981X(23)00031-8 [pii]
AID - 10.1016/j.cnp.2023.12.001 [doi]
PST - epublish
SO  - Clin Neurophysiol Pract. 2023 Dec 12;9:13-20. doi: 10.1016/j.cnp.2023.12.001. 
      eCollection 2024.