PMID- 38224015
OWN - NLM
STAT- Publisher
LR  - 20240119
IS  - 1616-5195 (Electronic)
IS  - 1616-5187 (Linking)
DP  - 2024 Jan 15
TI  - Development of BDNF/NGF/IKVAV Peptide Modified and Gold Nanoparticle Conductive 
      PCL/PLGA Nerve Guidance Conduit for Regeneration of the Rat Spinal Cord Injury.
PG  - e2300453
LID - 10.1002/mabi.202300453 [doi]
AB  - Spinal cord injuries are very common worldwide, leading to permanent nerve 
      function loss with devastating effects in the affected patients. The challenges 
      and inadequate results in the current clinical treatments are leading scientists 
      to innovative neural regenerative research. Advances in nanoscience and neural 
      tissue engineering have opened new avenues for spinal cord injury (SCI) 
      treatment. In order for designed nerve guidance conduit (NGC) to be functionally 
      useful, it must have ideal scaffold properties and topographic features that 
      promote the linear orientation of damaged axons. In this study, it is aimed to 
      develop channeled polycaprolactone (PCL)/Poly-D,L-lactic-co-glycolic acid (PLGA) 
      hybrid film scaffolds, modify their surfaces by IKVAV pentapeptide/gold 
      nanoparticles (AuNPs) or polypyrrole (PPy) and investigate the behavior of motor 
      neurons on the designed scaffold surfaces in vitro under static/bioreactor 
      conditions. Their potential to promote neural regeneration after implantation 
      into the rat SCI by shaping the film scaffolds modified with neural factors into 
      a tubular form is also examined. It is shown that channeled groups decorated with 
      AuNPs highly promote neurite orientation under bioreactor conditions and also the 
      developed optimal NGC (PCL/PLGA G1-IKVAV/BDNF/NGF-AuNP(50) ) highly regenerates 
      SCI. The results indicate that the designed scaffold can be an ideal candidate 
      for spinal cord regeneration.
CI  - (c) 2024 Wiley-VCH GmbH.
FAU - Ozcicek, Ilyas
AU  - Ozcicek I
AUID- ORCID: 0000-0002-4495-7395
AD  - Research Institute for Health Sciences and Technologies (SABITA), Istanbul 
      Medipol University, Istanbul, 34810, Turkey.
AD  - Department of Medical Biology, School of Medicine, Istanbul Medipol University, 
      Istanbul, 34815, Turkey.
FAU - Aysit, Nese
AU  - Aysit N
AD  - Research Institute for Health Sciences and Technologies (SABITA), Istanbul 
      Medipol University, Istanbul, 34810, Turkey.
AD  - Department of Medical Biology, School of Medicine, Istanbul Medipol University, 
      Istanbul, 34815, Turkey.
FAU - Balcikanli, Zeynep
AU  - Balcikanli Z
AD  - Research Institute for Health Sciences and Technologies (SABITA), Istanbul 
      Medipol University, Istanbul, 34810, Turkey.
FAU - Ayturk, Nilufer Ulas
AU  - Ayturk NU
AD  - Department of Histology and Embryology, Faculty of Medicine, Canakkale Onsekiz 
      Mart University, Canakkale, 17020, Turkey.
FAU - Aydeger, Asel
AU  - Aydeger A
AD  - Research Institute for Health Sciences and Technologies (SABITA), Istanbul 
      Medipol University, Istanbul, 34810, Turkey.
AD  - Graduate School of Health Sciences, Istanbul Medipol University, Istanbul, 34815, 
      Turkey.
FAU - Baydas, Gulsena
AU  - Baydas G
AD  - Research Institute for Health Sciences and Technologies (SABITA), Istanbul 
      Medipol University, Istanbul, 34810, Turkey.
AD  - Graduate School of Health Sciences, Istanbul Medipol University, Istanbul, 34815, 
      Turkey.
AD  - Department of Physiology, School of Medicine, Istanbul Medipol University, 
      Istanbul, 34815, Turkey.
FAU - Aydin, Mehmet Serif
AU  - Aydin MS
AD  - Research Institute for Health Sciences and Technologies (SABITA), Istanbul 
      Medipol University, Istanbul, 34810, Turkey.
FAU - Altintas, Esra
AU  - Altintas E
AD  - Research Institute for Health Sciences and Technologies (SABITA), Istanbul 
      Medipol University, Istanbul, 34810, Turkey.
AD  - Graduate School of Health Sciences, Istanbul Medipol University, Istanbul, 34815, 
      Turkey.
FAU - Erim, Umit Can
AU  - Erim UC
AD  - Research Institute for Health Sciences and Technologies (SABITA), Istanbul 
      Medipol University, Istanbul, 34810, Turkey.
AD  - Department of Analytical Chemistry, School of Pharmacy, Istanbul Medipol 
      University, Istanbul, 34815, Turkey.
LA  - eng
GR  - 119S141/Scientific and Technological Research Council of Turkey/
PT  - Journal Article
DEP - 20240115
PL  - Germany
TA  - Macromol Biosci
JT  - Macromolecular bioscience
JID - 101135941
SB  - IM
OTO - NOTNLM
OT  - gold nanoparticles
OT  - nerve guidance conduit
OT  - neural tissue engineering
OT  - neuronal regeneration
OT  - polycaprolactone/poly-lactic-glycolic acid
OT  - spinal cord injury
EDAT- 2024/01/15 06:42
MHDA- 2024/01/15 06:42
CRDT- 2024/01/15 05:53
PHST- 2023/12/22 00:00 [revised]
PHST- 2023/10/04 00:00 [received]
PHST- 2024/01/15 06:42 [pubmed]
PHST- 2024/01/15 06:42 [medline]
PHST- 2024/01/15 05:53 [entrez]
AID - 10.1002/mabi.202300453 [doi]
PST - aheadofprint
SO  - Macromol Biosci. 2024 Jan 15:e2300453. doi: 10.1002/mabi.202300453.