PMID- 38227367 OWN - NLM STAT- MEDLINE DCOM- 20240328 LR - 20240329 IS - 2198-3844 (Electronic) IS - 2198-3844 (Linking) VI - 11 IP - 12 DP - 2024 Mar TI - An Electroencephalography Profile of Paroxysmal Kinesigenic Dyskinesia. PG - e2306321 LID - 10.1002/advs.202306321 [doi] LID - 2306321 AB - Paroxysmal kinesigenic dyskinesia (PKD) is associated with a disturbance of neural circuit and network activities, while its neurophysiological characteristics have not been fully elucidated. This study utilized the high-density electroencephalogram (hd-EEG) signals to detect abnormal brain activity of PKD and provide a neural biomarker for its clinical diagnosis and PKD progression monitoring. The resting hd-EEGs are recorded from two independent datasets and then source-localized for measuring the oscillatory activities and function connectivity (FC) patterns of cortical and subcortical regions. The abnormal elevation of theta oscillation in wildly brain regions represents the most remarkable physiological feature for PKD and these changes returned to healthy control level in remission patients. Another remarkable feature of PKD is the decreased high-gamma FCs in non-remission patients. Subtype analyses report that increased theta oscillations may be related to the emotional factors of PKD, while the decreased high-gamma FCs are related to the motor symptoms. Finally, the authors established connectome-based predictive modelling and successfully identified the remission state in PKD patients in dataset 1 and dataset 2. The findings establish a clinically relevant electroencephalography profile of PKD and indicate that hd-EEG can provide robust neural biomarkers to evaluate the prognosis of PKD. CI - (c) 2024 The Authors. Advanced Science published by Wiley-VCH GmbH. FAU - Luo, Huichun AU - Luo H AD - Department of Neurology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China. AD - Shanghai Key Laboratory of Psychotic Disorders, Brain Health Institute, National Center for Mental Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China. FAU - Huang, Xiaojun AU - Huang X AD - Department of Neurology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China. FAU - Li, Ziyi AU - Li Z AD - Department of Neurology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China. FAU - Tian, Wotu AU - Tian W AD - Department of Neurology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China. FAU - Fang, Kan AU - Fang K AD - Department of Neurology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China. AD - Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China. FAU - Liu, Taotao AU - Liu T AD - Department of Neurology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China. FAU - Wang, Shige AU - Wang S AD - Department of Neurology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China. FAU - Tang, Beisha AU - Tang B AD - Department of Neurology, Xiangya Hospital, Central South University, Hunan Province, 410008, China. FAU - Hu, Ji AU - Hu J AD - School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. FAU - Yuan, Ti-Fei AU - Yuan TF AD - Shanghai Key Laboratory of Psychotic Disorders, Brain Health Institute, National Center for Mental Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China. AD - Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, 226019, China. AD - Institute of Mental Health and drug discovery, Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, Zhejiang, 325000, China. FAU - Cao, Li AU - Cao L AUID- ORCID: 0000-0003-1742-9877 AD - Department of Neurology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China. AD - Shanghai Neurological Rare Disease Biobank and Precision Diagnostic Technical Service Platform, Shanghai, China. LA - eng GR - 2022LJ011/Shanghai Municipal Health Commission/ GR - 82371255/National Natural Science Foundation of China/ GR - 82201398/National Natural Science Foundation of China/ GR - 82071258/National Natural Science Foundation of China/ GR - 81870889/National Natural Science Foundation of China/ GR - SHDC2022CRD037/Shanghai Hospital Development Center/ GR - 23XD1402500/Science and Technology Commission of Shanghai Municipality/ GR - 23DZ2291500/Science and Technology Commission of Shanghai Municipality/ PT - Journal Article DEP - 20240116 PL - Germany TA - Adv Sci (Weinh) JT - Advanced science (Weinheim, Baden-Wurttemberg, Germany) JID - 101664569 RN - Familial paroxysmal dystonia SB - IM MH - Humans MH - *Dystonia MH - Electroencephalography MH - Brain PMC - PMC10966565 OTO - NOTNLM OT - functional connectivity OT - high-density electroencephalogram OT - oscillatory activity OT - paroxysmal kinesigenic dyskinesia COIS- The authors declare no conflict of interest. EDAT- 2024/01/16 13:42 MHDA- 2024/03/28 06:44 PMCR- 2024/01/16 CRDT- 2024/01/16 12:03 PHST- 2023/11/24 00:00 [revised] PHST- 2023/09/03 00:00 [received] PHST- 2024/03/28 06:44 [medline] PHST- 2024/01/16 13:42 [pubmed] PHST- 2024/01/16 12:03 [entrez] PHST- 2024/01/16 00:00 [pmc-release] AID - ADVS7375 [pii] AID - 10.1002/advs.202306321 [doi] PST - ppublish SO - Adv Sci (Weinh). 2024 Mar;11(12):e2306321. doi: 10.1002/advs.202306321. Epub 2024 Jan 16.