PMID- 38227552
OWN - NLM
STAT- Publisher
LR  - 20240116
IS  - 1745-7262 (Electronic)
IS  - 1008-682X (Linking)
DP  - 2024 Jan 12
TI  - Exploring the impact of pericentric inversion of chromosome 9 on fertility in 
      sperm donors.
LID - 10.4103/aja202369 [doi]
AB  - Pericentric inversion of chromosome 9 (inv[9]) is a common chromosomal structural 
      variant, but its impact on clinical outcomes remains debated. The screening 
      criteria of sperm banks are rarely mentioned to individuals with inv(9). In this 
      study, we evaluated the fertility of sperm donors with inv(9) who met eligibility 
      criteria for sperm banks (inv[9]-eligible donors). From March 2004 to May 2022, 
      chromosomal analysis of 16 124 sperm donors at CITIC-Xiangya Human Sperm Bank in 
      Hunan Province (Changsha, China) found that 251 (1.6%) had chromosome variations, 
      with inv(9) being the most prevalent at 1.1%. All 169 inv(9)-eligible donors were 
      contacted to collect fertility outcome data, along with 206 eligible donors 
      without inv(9) as controls. In addition, semen samples from inv(9)-eligible 
      donors and eligible donors underwent assessments of sperm fluorescence in situ 
      hybridization (FISH), mitochondrial membrane potential, DNA fragmentation index, 
      acrosome integrity, reactive oxygen species (ROS), and sperm morphology. Results 
      showed that inv(9) did not significantly increase reproductive risks overall. 
      Despite detecting ROS level differences, the clinical impact may be 
      insignificant. This study provides new data on the inv(9) population that can 
      serve as a valuable reference for decision-making by sperm banks as well as for 
      genetic counseling and clinical guidance for individuals carrying inv(9) variant.
CI  - Copyright (c) 2024 Copyright: (c) The Author(s)(2024).
FAU - Liu, Qian
AU  - Liu Q
AD  - Institute of Reproductive and Stem Cell Engineering, Basic Medicine College, 
      Central South University, Changsha 410013, China.
FAU - Zhou, Wen-Jun
AU  - Zhou WJ
AD  - Institute of Reproductive and Stem Cell Engineering, Basic Medicine College, 
      Central South University, Changsha 410013, China.
FAU - Huang, Zeng-Hui
AU  - Huang ZH
AD  - Institute of Reproductive and Stem Cell Engineering, Basic Medicine College, 
      Central South University, Changsha 410013, China.
AD  - Clinical Research Center for Reproduction and Genetics in Hunan Province, 
      Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha 410005, China.
FAU - Huang, Xiu-Hai
AU  - Huang XH
AD  - Clinical Research Center for Reproduction and Genetics in Hunan Province, 
      Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha 410005, China.
FAU - Wu, Jian
AU  - Wu J
AD  - Clinical Research Center for Reproduction and Genetics in Hunan Province, 
      Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha 410005, China.
FAU - Ji, Xi-Ren
AU  - Ji XR
AD  - Clinical Research Center for Reproduction and Genetics in Hunan Province, 
      Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha 410005, China.
FAU - Luo, Xue-Feng
AU  - Luo XF
AD  - Institute of Reproductive and Stem Cell Engineering, Basic Medicine College, 
      Central South University, Changsha 410013, China.
FAU - Tang, Yu-Ling
AU  - Tang YL
AD  - Institute of Reproductive and Stem Cell Engineering, Basic Medicine College, 
      Central South University, Changsha 410013, China.
FAU - Wang, Rui-Jun
AU  - Wang RJ
AD  - Institute of Reproductive and Stem Cell Engineering, Basic Medicine College, 
      Central South University, Changsha 410013, China.
FAU - Fan, Li-Qing
AU  - Fan LQ
AD  - Institute of Reproductive and Stem Cell Engineering, Basic Medicine College, 
      Central South University, Changsha 410013, China.
AD  - Clinical Research Center for Reproduction and Genetics in Hunan Province, 
      Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha 410005, China.
FAU - Huang, Chuan
AU  - Huang C
AD  - Clinical Research Center for Reproduction and Genetics in Hunan Province, 
      Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha 410005, China.
FAU - Zhu, Wen-Bing
AU  - Zhu WB
AD  - Institute of Reproductive and Stem Cell Engineering, Basic Medicine College, 
      Central South University, Changsha 410013, China.
AD  - Clinical Research Center for Reproduction and Genetics in Hunan Province, 
      Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha 410005, China.
LA  - eng
PT  - Journal Article
DEP - 20240112
PL  - China
TA  - Asian J Androl
JT  - Asian journal of andrology
JID - 100942132
SB  - IM
EDAT- 2024/01/16 18:41
MHDA- 2024/01/16 18:41
CRDT- 2024/01/16 13:13
PHST- 2023/09/24 00:00 [received]
PHST- 2023/11/03 00:00 [accepted]
PHST- 2024/01/16 18:41 [medline]
PHST- 2024/01/16 18:41 [pubmed]
PHST- 2024/01/16 13:13 [entrez]
AID - 00129336-990000000-00153 [pii]
AID - 10.4103/aja202369 [doi]
PST - aheadofprint
SO  - Asian J Androl. 2024 Jan 12. doi: 10.4103/aja202369.