PMID- 38228848
OWN - NLM
STAT- MEDLINE
DCOM- 20240118
LR  - 20240204
IS  - 1432-1955 (Electronic)
IS  - 0932-0113 (Print)
IS  - 0932-0113 (Linking)
VI  - 123
IP  - 1
DP  - 2024 Jan 17
TI  - Toxocarosis in a patient with autism spectrum disorder presenting with severe 
      hypereosinophilia and acute respiratory distress: a case report.
PG  - 99
LID - 10.1007/s00436-024-08119-y [doi]
LID - 99
AB  - A boy with known autism spectrum disorder was transferred to our department due 
      to a rapidly worsening respiratory situation. The patient's history revealed 
      previous treatment with albendazole against a Toxocara infection 2 weeks prior in 
      Poland. Blood analysis showed such severe eosinophilia and markedly elevated 
      levels of IgE that, initially, a hematologic malignancy was suspected. However, 
      diagnostic workup including autoimmune diagnostic, molecular genetic testing, 
      fluorescence in situ hybridization (FISH), bone marrow aspiration, and 
      parasitological testing led to the diagnosis of an insufficiently treated 
      Toxocara infection. Treatment with albendazole and prednisone (six cycles for 4 
      weeks each) was administered. This treatment regime led to prompt improvement of 
      symptoms and normalization of laboratory findings.
CI  - (c) 2024. The Author(s).
FAU - Ublagger, Daniel
AU  - Ublagger D
AD  - St. Anna Children's Hospital, Department of Pediatrics, Medical University 
      Vienna, Vienna, Austria.
FAU - Auer, Herbert
AU  - Auer H
AD  - Medical Parasitology, Institute of Specific Prophylaxis and Tropical Medicine, 
      Center of Pathophysiology, Infectiology and Immunology, Medical University 
      Vienna, Vienna, Austria.
FAU - Bezakova, Milina
AU  - Bezakova M
AD  - St. Anna Children's Hospital, Department of Pediatrics, Medical University 
      Vienna, Vienna, Austria.
FAU - Kirchlechner, Veronika
AU  - Kirchlechner V
AD  - St. Anna Children's Hospital, Department of Pediatrics, Medical University 
      Vienna, Vienna, Austria. veronika.kirchlechner@stanna.at.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20240117
PL  - Germany
TA  - Parasitol Res
JT  - Parasitology research
JID - 8703571
RN  - F4216019LN (Albendazole)
SB  - IM
MH  - Male
MH  - Animals
MH  - Humans
MH  - Albendazole/therapeutic use
MH  - *Autism Spectrum Disorder/complications/diagnosis/drug therapy
MH  - In Situ Hybridization, Fluorescence
MH  - *Toxocariasis/diagnosis
MH  - *Eosinophilia/diagnosis/drug therapy
MH  - *Respiratory Distress Syndrome
PMC - PMC10791809
OTO - NOTNLM
OT  - Albendazole
OT  - Autism spectrum disorder
OT  - Geophagia
OT  - Toxocarosis
COIS- The authors declare no competing interests.
EDAT- 2024/01/17 00:41
MHDA- 2024/01/18 06:42
PMCR- 2024/01/17
CRDT- 2024/01/16 23:26
PHST- 2023/11/06 00:00 [received]
PHST- 2024/01/07 00:00 [accepted]
PHST- 2024/01/18 06:42 [medline]
PHST- 2024/01/17 00:41 [pubmed]
PHST- 2024/01/16 23:26 [entrez]
PHST- 2024/01/17 00:00 [pmc-release]
AID - 10.1007/s00436-024-08119-y [pii]
AID - 8119 [pii]
AID - 10.1007/s00436-024-08119-y [doi]
PST - epublish
SO  - Parasitol Res. 2024 Jan 17;123(1):99. doi: 10.1007/s00436-024-08119-y.