PMID- 38230764
OWN - NLM
STAT- MEDLINE
DCOM- 20240304
LR  - 20240304
IS  - 2045-7634 (Electronic)
IS  - 2045-7634 (Linking)
VI  - 13
IP  - 3
DP  - 2024 Feb
TI  - Biomarkers of peripheral blood neutrophil extracellular traps in the diagnosis 
      and progression of malignant tumors.
PG  - e6935
LID - 10.1002/cam4.6935 [doi]
LID - e6935
AB  - BACKGROUND AND AIMS: The mortality rate associated with malignant tumors remains 
      high and there is a lack of effective diagnostic and tumor progression markers. 
      Neutrophil extracellular traps (NETs) can promote tumor-associated thrombosis, 
      invasive metastasis, and inflammatory responses, but there is a lack of research 
      on the value of measuring NETs in the peripheral blood of patients with 
      malignancies. METHODS: We included 263 patients with malignancies (55 gliomas, 
      101 ovarian, 64 colorectal, and 43 lung cancers) and 75 healthy controls in this 
      study. We compared the levels of citrullinated histone H3 (citH3), cell-free DNA 
      (cfDNA), and systemic inflammation-related parameters, including neutrophils, 
      lymphocytes, monocytes, platelets, neutrophil-to-lymphocyte ratio, 
      monocyte-to-lymphocyte ratio, platelet-to-lymphocyte ratio, systemic immune 
      inflammation index, and systemic inflammation response index. We assessed the 
      value of changes in NETs in peripheral blood to determine the diagnosis, venous 
      thromboembolism, clinical staging, and systemic inflammatory response in patients 
      with malignancy. RESULTS: The levels of citH3 and cfDNA in peripheral blood can 
      distinguish between healthy controls and tumor patients. The levels of citH3 and 
      cfDNA before clinical intervention did not predict the risk of combined venous 
      thromboembolism in oncology patients in the short-term after clinical 
      intervention. The levels of citH3, cfDNA, and systemic inflammation-related 
      parameters in the peripheral blood of tumor patients increased with the clinical 
      stage. There was a correlation between cfDNA levels in peripheral blood and 
      systemic inflammation-related parameters in tumor patients, and this correlation 
      was more significant in patients with advanced tumors. CONCLUSIONS: Changes in 
      NETs in the peripheral blood differ between healthy controls and patients with 
      malignant tumors. NETs may be involved in tumor-induced systemic inflammatory 
      responses through interaction with circulating inflammatory cells, thus promoting 
      tumor progression. NETs may be used as markers to assist in the diagnosis and 
      progression of tumor malignancy.
CI  - (c) 2024 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
FAU - Wang, Min
AU  - Wang M
AUID- ORCID: 0009-0006-2371-0285
AD  - Department of Blood Transfusion, Second Hospital of Jilin University, Changchun, 
      China.
FAU - Lv, Xiaoyan
AU  - Lv X
AD  - Department of Experimental Medicine, Second Hospital of Jilin University, 
      Changchun, China.
FAU - Wang, Ying
AU  - Wang Y
AD  - Department of Experimental Medicine, Second Hospital of Jilin University, 
      Changchun, China.
FAU - Li, Yao
AU  - Li Y
AD  - Department of Blood Transfusion, Second Hospital of Jilin University, Changchun, 
      China.
FAU - Li, Honghong
AU  - Li H
AD  - Department of Blood Transfusion, Second Hospital of Jilin University, Changchun, 
      China.
FAU - Shen, Zhongjun
AU  - Shen Z
AD  - Department of Blood Transfusion, Second Hospital of Jilin University, Changchun, 
      China.
FAU - Zhao, Liyan
AU  - Zhao L
AD  - Department of Blood Transfusion, Second Hospital of Jilin University, Changchun, 
      China.
LA  - eng
GR  - 20200801023GH/The Jilin Province Science and Technology Development Planning 
      Project/
PT  - Journal Article
DEP - 20240117
PL  - United States
TA  - Cancer Med
JT  - Cancer medicine
JID - 101595310
RN  - 0 (Histones)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Cell-Free Nucleic Acids)
SB  - IM
MH  - Humans
MH  - Neutrophils
MH  - *Extracellular Traps
MH  - *Venous Thromboembolism
MH  - Histones
MH  - Biomarkers, Tumor
MH  - *Lung Neoplasms
MH  - *Cell-Free Nucleic Acids
MH  - Inflammation/diagnosis
PMC - PMC10905219
OTO - NOTNLM
OT  - cell-free DNA
OT  - citrullinated histone H3
OT  - neutrophil extracellular traps
OT  - systemic inflammatory response
OT  - tumor progression
OT  - tumor-associated thrombosis
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2024/01/17 12:44
MHDA- 2024/03/04 06:43
PMCR- 2024/01/17
CRDT- 2024/01/17 08:04
PHST- 2023/12/20 00:00 [revised]
PHST- 2023/05/02 00:00 [received]
PHST- 2023/12/24 00:00 [accepted]
PHST- 2024/03/04 06:43 [medline]
PHST- 2024/01/17 12:44 [pubmed]
PHST- 2024/01/17 08:04 [entrez]
PHST- 2024/01/17 00:00 [pmc-release]
AID - CAM46935 [pii]
AID - 10.1002/cam4.6935 [doi]
PST - ppublish
SO  - Cancer Med. 2024 Feb;13(3):e6935. doi: 10.1002/cam4.6935. Epub 2024 Jan 17.