PMID- 38230793
OWN - NLM
STAT- MEDLINE
DCOM- 20240118
LR  - 20240325
IS  - 1747-0285 (Electronic)
IS  - 1747-0277 (Linking)
VI  - 103
IP  - 1
DP  - 2024 Jan
TI  - Protective effect of naringin against radiation-induced heart disease in rats via 
      Sirt1/NF-kappaB signaling pathway and endoplasmic reticulum stress.
PG  - e14453
LID - 10.1111/cbdd.14453 [doi]
AB  - This study was designed to explore the protective effect and mechanism of 
      naringin (NG) on radiation-induced heart disease (RIHD) in rats. Rats were 
      divided into four x-ray (XR) irradiation groups with different absorbed doses 
      (0/10/15/20 Gy), or into three groups (control, XR, and XR + NG groups). 
      Subsequently, the ultrasonic diagnostic apparatus was adopted to assess and 
      compare the left ventricular ejection fraction (LVEF), left ventricular 
      fractional shortening (LVFS), left ventricular internal diameter at end diastole 
      (LVIDd), and left ventricular internal diameter at end systole (LVIDs) in rats. 
      Hematoxylin-eosin (H&E) staining and Masson staining were applied to detect the 
      pathological damage and fibrosis of heart tissue. Western blot was used to 
      measure the expression levels of myocardial fibrosis-related proteins, 
      endoplasmic reticulum stress-related proteins, and Sirt1 (silent information 
      regulator 1)/NF-kappaB (nuclear factor kappa-B) signaling pathway-related proteins in 
      cardiac tissues. Additionally, enzyme-linked immunosorbent assay was utilized to 
      detect the activities of pro-inflammatory cytokines, malondialdehyde (MDA), 
      superoxide dismutase (SOD), and catalase (CAT) in cardiac tissue. The results 
      showed that NG treatment significantly attenuated the 20 Gy XR-induced decline of 
      LVEF and LVFS and the elevation of LVIDs. Cardiac tissue damage and fibrosis 
      caused by 20 Gy XR were significant improved after NG treatment. Meanwhile, in 
      rats irradiated by XR, marked downregulation was identified in the expressions of 
      fibrosis-related proteins (Col I, collagen type I; alpha-SMA, alpha-smooth muscle actin; 
      and TGF-beta1, transforming growth factor-beta 1) and endoplasmic reticulum 
      stress-related proteins (GRP78, glucose regulatory protein 78; CHOP, C/EBP 
      homologous protein; ATF6, activating transcription factor 6; and caspase 12) 
      after NG treatment. Moreover, NG treatment also inhibited the production of 
      pro-inflammatory cytokines [interleukin-6, interleukin-1beta, and monocyte 
      chemoattractant protein-1 (MCP-1)], reduced the expression of MDA, and promoted 
      the activities of SOD and CAT. Also, NG treatment promoted Sirt1 expression and 
      inhibited p65 phosphorylation. Collectively, XR irradiation induced cardiac 
      injury in rats in a dose-dependent manner. NG could improve the cardiac injury 
      induced by XR irradiation by inhibiting endoplasmic reticulum stress and 
      activating Sirt1/NF-kappaB signaling pathway.
CI  - (c) 2024 John Wiley & Sons Ltd.
FAU - Liu, Shu-Ting
AU  - Liu ST
AD  - Department of Radiology, The First Affiliated Hospital of Zhengzhou University, 
      Zhengzhou, Henan, China.
FAU - Zha, Kai-Ji
AU  - Zha KJ
AD  - Department of Radiology, The First Affiliated Hospital of Zhengzhou University, 
      Zhengzhou, Henan, China.
FAU - Li, Pei-Jie
AU  - Li PJ
AD  - Department of Radiology, The First Affiliated Hospital of Zhengzhou University, 
      Zhengzhou, Henan, China.
FAU - Gao, Jian-Bo
AU  - Gao JB
AD  - Department of Radiology, The First Affiliated Hospital of Zhengzhou University, 
      Zhengzhou, Henan, China.
FAU - Zhang, Yong-Gao
AU  - Zhang YG
AD  - Department of Radiology, The First Affiliated Hospital of Zhengzhou University, 
      Zhengzhou, Henan, China.
LA  - eng
GR  - SBGJ202102113/Henan Province Medical Science and Technology Key Project/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Chem Biol Drug Des
JT  - Chemical biology & drug design
JID - 101262549
RN  - 0 (NF-kappa B)
RN  - N7TD9J649B (naringin)
RN  - EC 3.5.1.- (Sirtuin 1)
RN  - 0 (Cytokines)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 3.5.1.- (Sirt1 protein, rat)
RN  - 0 (Flavanones)
SB  - IM
MH  - Rats
MH  - Animals
MH  - *NF-kappa B/metabolism
MH  - Sirtuin 1/metabolism
MH  - Stroke Volume
MH  - Rats, Sprague-Dawley
MH  - Ventricular Function, Left
MH  - Signal Transduction
MH  - Cytokines/metabolism
MH  - *Heart Diseases
MH  - Fibrosis
MH  - Superoxide Dismutase/metabolism
MH  - Endoplasmic Reticulum Stress
MH  - *Flavanones
OTO - NOTNLM
OT  - Sirt1/NF-kappaB signaling pathway
OT  - endoplasmic reticulum stress
OT  - naringin
OT  - radiation-induced heart disease
EDAT- 2024/01/17 12:43
MHDA- 2024/01/18 06:42
CRDT- 2024/01/17 08:04
PHST- 2023/12/01 00:00 [revised]
PHST- 2023/10/13 00:00 [received]
PHST- 2023/12/06 00:00 [accepted]
PHST- 2024/01/18 06:42 [medline]
PHST- 2024/01/17 12:43 [pubmed]
PHST- 2024/01/17 08:04 [entrez]
AID - 10.1111/cbdd.14453 [doi]
PST - ppublish
SO  - Chem Biol Drug Des. 2024 Jan;103(1):e14453. doi: 10.1111/cbdd.14453.