PMID- 38232503
OWN - NLM
STAT- MEDLINE
DCOM- 20240125
LR  - 20240201
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Linking)
VI  - 183
DP  - 2024 Jan
TI  - Prenatal exposure to per-and polyfluoroalkyl substances and child executive 
      function: Evidence from the Shanghai birth cohort study.
PG  - 108437
LID - S0160-4120(24)00023-0 [pii]
LID - 10.1016/j.envint.2024.108437 [doi]
AB  - BACKGROUND: Per-and polyfluoroalkyl substances (PFAS) are ubiquitous in the 
      environment and accumulate in humans. Toxicological studies have indicated the 
      potential neurotoxicity of PFAS during the fetal development. However, in 
      epidemiological studies, the association between prenatal exposure to PFAS and 
      executive function in offspring remains unclear. OBJECTIVES: To investigate the 
      association between prenatal exposure to PFAS and executive function in 
      offspring. METHOD: This study included 1765 mother-child pairs in the Shanghai 
      Birth Cohort, a prospective birth cohort enrolled during 2013-2016. The levels of 
      10 PFAS were measured in maternal plasma samples collected during early 
      gestation. Child executive function was assessed at 4 years of age using the 
      parent-reported Behavior Rating Inventory of Executive Function-Preschool version 
      (BRIEF-P), which provided 4 composite measures: Inhibitory Self-Control Index, 
      Flexibility Index, Emergent Metacognition Index, and Global Executive Composite. 
      We used multivariable linear regression to examine the associations between 
      individual PFAS and BRIEF-P scores. Bayesian kernel machine regression (BKMR) was 
      employed to evaluate the joint effects. We also investigated whether these 
      associations were modified by sex. RESULT: We found no significant associations 
      between prenatal PFAS exposure and BRIEF-P scores when the child was 4 years old. 
      BKMR analysis showed no joint effect of the PFAS mixture on child executive 
      function. RCS analysis indicated that the majority of relationships between PFAS 
      and BRIEF-P did not deviate from the linear relationship, even though there was a 
      nonlinear association between PFUA and EMI. Additionally, the associations were 
      not modified by sex. CONCLUSION: Overall, our findings showed that there were no 
      associations between prenatal exposure to PFAS and child executive function at 
      4 years of age.
CI  - Copyright (c) 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.
FAU - Yang, Xuchen
AU  - Yang X
AD  - MOE-Shanghai Key Laboratory of Children's Environmental Health, Xin Hua Hospital 
      Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China; 
      School of Public Health, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, China.
FAU - Zheng, Liqiang
AU  - Zheng L
AD  - School of Public Health, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, China. Electronic address: zhenglq@sjtu.edu.cn.
FAU - Zhang, Jun
AU  - Zhang J
AD  - MOE-Shanghai Key Laboratory of Children's Environmental Health, Xin Hua Hospital 
      Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China; 
      School of Public Health, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, China.
FAU - Wang, Hui
AU  - Wang H
AD  - MOE-Shanghai Key Laboratory of Children's Environmental Health, Xin Hua Hospital 
      Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China; 
      School of Public Health, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, China. Electronic address: whui2015@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20240111
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fluorocarbons)
RN  - 0 (Alkanesulfonic Acids)
SB  - IM
MH  - Pregnancy
MH  - Female
MH  - Child, Preschool
MH  - Humans
MH  - Cohort Studies
MH  - Executive Function
MH  - *Prenatal Exposure Delayed Effects
MH  - Prospective Studies
MH  - *Environmental Pollutants/toxicity
MH  - Bayes Theorem
MH  - *Fluorocarbons
MH  - China
MH  - *Alkanesulfonic Acids/toxicity
OTO - NOTNLM
OT  - Birth cohort
OT  - Executive function
OT  - Neurodevelopmental disorder
OT  - Per-and polyfluoroalkyl substances
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2024/01/18 00:42
MHDA- 2024/01/25 06:44
CRDT- 2024/01/17 18:05
PHST- 2023/08/21 00:00 [received]
PHST- 2024/01/08 00:00 [revised]
PHST- 2024/01/09 00:00 [accepted]
PHST- 2024/01/25 06:44 [medline]
PHST- 2024/01/18 00:42 [pubmed]
PHST- 2024/01/17 18:05 [entrez]
AID - S0160-4120(24)00023-0 [pii]
AID - 10.1016/j.envint.2024.108437 [doi]
PST - ppublish
SO  - Environ Int. 2024 Jan;183:108437. doi: 10.1016/j.envint.2024.108437. Epub 2024 
      Jan 11.