PMID- 38233008
OWN - NLM
STAT- MEDLINE
DCOM- 20240130
LR  - 20240130
IS  - 2173-5743 (Electronic)
IS  - 2173-5743 (Linking)
VI  - 20
IP  - 1
DP  - 2024 Jan
TI  - DKK-1 in psoriatic arthritis: Correlation with disease activity and enthesopathy.
PG  - 14-19
LID - S2173-5743(23)00130-2 [pii]
LID - 10.1016/j.reumae.2023.09.001 [doi]
AB  - BACKGROUND: Psoriatic arthritis (PsA) is a complex inflammatory disease with 
      varied clinical characteristics. A pathognomonic characteristic of PsA is 
      enthesitis. Entheseal inflammation ultimately leads to the production of new bone 
      (enthesophytes). Dickkopf-related protein-1 (DKK-1) is a wingless (Wnt) inhibitor 
      that inhibits osteoblast function. OBJECTIVES: Assessment of the serum level of 
      DKK-1 and its association with disease activity and enthesopathy in PsA patients. 
      METHODS: This observational case-control study included 50 PsA patients and 50 
      healthy volunteers matched for age and gender. All participants were subjected to 
      full medical history, clinical assessment, PSA activity using Disease Activity 
      Index for Psoriatic Arthritis (DAPSA) score, the severity and extent of psoriasis 
      were determined by the Psoriasis Area and Severity Index (PASI). Ultrasonographic 
      assessment of the entheses was done in accordance with the Madrid Sonographic 
      Enthesitis Index (MASEI). Serum level of DKK-1 and correlation with disease 
      activity and enthesopathy in PsA patients were assessed. RESULTS: There was no 
      significant difference between patients and controls regarding age and sex. The 
      mean value of SPARCC index, DAPSA score and PASI score were 6.74+/-4.58, 
      33.24+/-15.26, and 8.35+/-10.93, respectively. There was significant difference 
      between patients and controls regarding the serum levels of DKK-1 and MASEI score 
      (p<0.0001). There was a significant positive correlation between serum DKK-1 and 
      MASEI (r: 0.43527, p: 0.00158), MASEI inflammatory (r: 0.37958, p: 0.00655), and 
      MASEI damage (r: 0.38384, p: 0.00593). CONCLUSIONS: Serum DKK-1 levels were 
      elevated in PsA patients and were found to be correlated with MASEI score for 
      enthesopathy.
CI  - Copyright (c) 2023 Elsevier Espana, S.L.U. and Sociedad Espanola de Reumatologia y 
      Colegio Mexicano de Reumatologia. All rights reserved.
FAU - Wahba, Marian Aziz Wahba Abdo
AU  - Wahba MAWA
AD  - Department of Rheumatology and Rehabilitation, Tanta University, Tanta, Egypt.
FAU - El-Gazzar, Nagat Mohamed
AU  - El-Gazzar NM
AD  - Department of Rheumatology and Rehabilitation, Tanta University, Tanta, Egypt.
FAU - Elsharaby, Radwa Mahmoud
AU  - Elsharaby RM
AD  - Department of Clinical Pathology, Faculty of Medicine, Tanta University, Egypt.
FAU - Tabra, Samar Abdalhamed
AU  - Tabra SA
AD  - Department of Rheumatology and Rehabilitation, Tanta University, Tanta, Egypt. 
      Electronic address: Dr_stabra_113@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - Spain
TA  - Reumatol Clin (Engl Ed)
JT  - Reumatologia clinica
JID - 101717526
RN  - 0 (DKK1 protein, human)
SB  - IM
MH  - Humans
MH  - *Arthritis, Psoriatic/diagnostic imaging
MH  - Case-Control Studies
MH  - *Enthesopathy/diagnostic imaging
MH  - *Psoriasis
MH  - Ultrasonography
OTO - NOTNLM
OT  - Actividad de la enfermedad
OT  - Artritis psoriasica
OT  - DKK-1
OT  - Disease activity
OT  - Entesopatia
OT  - Enthesopathy
OT  - Psoriatic arthritis
EDAT- 2024/01/18 00:42
MHDA- 2024/01/19 06:42
CRDT- 2024/01/17 20:52
PHST- 2023/04/17 00:00 [received]
PHST- 2023/06/08 00:00 [accepted]
PHST- 2024/01/19 06:42 [medline]
PHST- 2024/01/18 00:42 [pubmed]
PHST- 2024/01/17 20:52 [entrez]
AID - S2173-5743(23)00130-2 [pii]
AID - 10.1016/j.reumae.2023.09.001 [doi]
PST - ppublish
SO  - Reumatol Clin (Engl Ed). 2024 Jan;20(1):14-19. doi: 10.1016/j.reumae.2023.09.001.