PMID- 38233371 OWN - NLM STAT- MEDLINE DCOM- 20240119 LR - 20240222 IS - 1365-2060 (Electronic) IS - 0785-3890 (Print) IS - 0785-3890 (Linking) VI - 55 IP - 2 DP - 2023 TI - The clinical characteristics and outcomes of different inhaled therapies in chronic obstructive pulmonary disease patients with frequent cough. PG - 2304107 LID - 10.1080/07853890.2024.2304107 [doi] LID - 2304107 AB - BACKGROUND: Cough is a common symptom in patients with chronic obstructive pulmonary disease (COPD). Patients with cough may exhibit various clinical characteristics and experience varying outcomes based on inhaled therapies they receive. OBJECTIVES: This study aimed to explore the clinical characteristics and outcomes of various inhaled therapies in COPD patients with frequent cough. METHODS: This was a multicenter, prospective cohort study. Of these patients, the median cough score in COPD assessment test (CAT) was two. Patients were classified into frequent cough group if they scored two or over in the first item of CAT and infrequent cough group otherwise. Patients with frequent cough were then divided into long-acting antimuscarinic (LAMA), long-acting beta2-agonist (LABA)/LAMA, inhaled corticosteroids (ICS)/LABA and ICS/LABA/LAMA groups. Minimum clinically important difference (MCID) (CAT scores decreased >/=2 from baseline) and the improvement of cough (cough score decreased >/=1 from baseline) were collected in the six-month follow-up. Frequent exacerbations (experiencing at least two exacerbations) were collected in the one-year follow-up. RESULTS: Of 906 patients, 581 (64.1%) patients reported frequent cough at the initial visit. Frequent cough was associated with the current smokers and CAT scores (p < 0.05). The MCID showed no significant difference between frequent cough and infrequent cough groups in the follow-up. More patients with frequent cough experienced future frequent exacerbations compared to those with infrequent cough. After receiving inhaled therapies, 62% of patients with frequent cough got the cough improved. More patients with frequent cough treated with LABA/LAMA or ICS/LABA/LAMA attained MCID and fewer experienced exacerbations than those treated with LAMA or ICS/LABA (p < 0.05). The change in cough score showed no difference among various inhaled therapies in patients with frequent cough. CONCLUSION: COPD patients with frequent cough were related to current smokers and higher CAT scores. These patients had a higher incidence of frequent exacerbations than those with infrequent cough. Patients with frequent cough who were treated with LABA/LAMA or ICS/LABA/LAMA were more likely to attain MCID and at a lower risk of exacerbation than those treated with LAMA or ICS/LABA. FAU - Li, Xueshan AU - Li X AD - Department of Respiratory and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China. AD - Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, China. AD - Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, China. AD - Clinical Medical Research Center for Respiratory and Critical Care Medicine in Hunan Province, China. FAU - Song, Qing AU - Song Q AD - Department of Respiratory and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China. AD - Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, China. AD - Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, China. AD - Clinical Medical Research Center for Respiratory and Critical Care Medicine in Hunan Province, China. FAU - Cheng, Wei AU - Cheng W AUID- ORCID: 0000-0003-1025-0591 AD - Department of Respiratory and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China. AD - Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, China. AD - Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, China. AD - Clinical Medical Research Center for Respiratory and Critical Care Medicine in Hunan Province, China. FAU - Liu, Cong AU - Liu C AD - Department of Respiratory and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China. AD - Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, China. AD - Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, China. AD - Clinical Medical Research Center for Respiratory and Critical Care Medicine in Hunan Province, China. FAU - Lin, Ling AU - Lin L AD - Department of Respiratory and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China. AD - Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, China. AD - Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, China. AD - Clinical Medical Research Center for Respiratory and Critical Care Medicine in Hunan Province, China. FAU - Li, Jing AU - Li J AD - Department of Respiratory and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China. AD - Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, China. AD - Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, China. AD - Clinical Medical Research Center for Respiratory and Critical Care Medicine in Hunan Province, China. FAU - Peng, Yating AU - Peng Y AD - Department of Respiratory and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China. AD - Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, China. AD - Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, China. AD - Clinical Medical Research Center for Respiratory and Critical Care Medicine in Hunan Province, China. FAU - Zeng, Yuqin AU - Zeng Y AD - Department of Respiratory and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China. AD - Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, China. AD - Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, China. AD - Clinical Medical Research Center for Respiratory and Critical Care Medicine in Hunan Province, China. FAU - Yi, Rong AU - Yi R AD - Department of Pulmonary and Critical Care Medicine, Zhuzhou Central Hospital, Zhuzhou, Hunan, China. FAU - Liu, Yi AU - Liu Y AD - Department of Pulmonary and Critical Care Medicine, Zhuzhou Central Hospital, Zhuzhou, Hunan, China. FAU - Li, Xin AU - Li X AD - Division 4 of Occupational Diseases, Hunan Prevention and Treatment Institute for Occupational Disease, Changsha, Hunan, China. FAU - Chen, Yan AU - Chen Y AD - Department of Respiratory and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China. AD - Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, China. AD - Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, China. AD - Clinical Medical Research Center for Respiratory and Critical Care Medicine in Hunan Province, China. FAU - Cai, Shan AU - Cai S AD - Department of Respiratory and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China. AD - Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, China. AD - Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, China. AD - Clinical Medical Research Center for Respiratory and Critical Care Medicine in Hunan Province, China. FAU - Chen, Ping AU - Chen P AUID- ORCID: 0000-0001-6707-8636 AD - Department of Respiratory and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China. AD - Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, China. AD - Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, China. AD - Clinical Medical Research Center for Respiratory and Critical Care Medicine in Hunan Province, China. LA - eng PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't DEP - 20240117 PL - England TA - Ann Med JT - Annals of medicine JID - 8906388 RN - 0 (Adrenergic beta-2 Receptor Agonists) RN - 0 (Muscarinic Antagonists) RN - 0 (Adrenal Cortex Hormones) RN - 0 (Bronchodilator Agents) SB - IM MH - Humans MH - Prospective Studies MH - *Adrenergic beta-2 Receptor Agonists/adverse effects MH - Administration, Inhalation MH - *Pulmonary Disease, Chronic Obstructive/complications/drug therapy MH - Muscarinic Antagonists/therapeutic use/adverse effects MH - Adrenal Cortex Hormones/therapeutic use MH - Bronchodilator Agents/therapeutic use MH - Drug Therapy, Combination PMC - PMC10795788 OTO - NOTNLM OT - Chronic obstructive pulmonary disease OT - exacerbation OT - frequent cough OT - minimum clinically important difference COIS- No potential conflict of interest was reported by the author(s). EDAT- 2024/01/18 00:42 MHDA- 2024/01/19 06:42 PMCR- 2024/01/17 CRDT- 2024/01/17 23:02 PHST- 2024/01/19 06:42 [medline] PHST- 2024/01/18 00:42 [pubmed] PHST- 2024/01/17 23:02 [entrez] PHST- 2024/01/17 00:00 [pmc-release] AID - 2304107 [pii] AID - 10.1080/07853890.2024.2304107 [doi] PST - ppublish SO - Ann Med. 2023;55(2):2304107. doi: 10.1080/07853890.2024.2304107. Epub 2024 Jan 17.