PMID- 38236144
OWN - NLM
STAT- Publisher
LR  - 20240210
IS  - 2047-4881 (Electronic)
IS  - 2047-4873 (Linking)
DP  - 2024 Jan 17
TI  - Homocysteine, hyperhomocysteinemia and H-type hypertension.
LID - zwae022 [pii]
LID - 10.1093/eurjpc/zwae022 [doi]
AB  - Homocysteine (Hcy) is a sulfur-containing nonessential amino acid derived from 
      the intermediate metabolites of methionine. Methionine is obtained from dietary 
      proteins, such as poultry, meat, eggs, seafood, and dairy products. Abnormalities 
      in Hcy metabolic pathways, deficiencies in dietary methionine, folate, and 
      vitamins B12, B6 and B2 and genetic defects, polymorphisms, or mutations in Hcy 
      metabolism-related enzymes may lead to an increase in plasma Hcy levels. 
      Generally, a plasma Hcy level higher than 10 mumol/L or 15 mumol/L has been defined 
      as hyperhomocysteinemia (HHcy). An individual with essential hypertension 
      complicated with HHcy is considered to have H-type hypertension (HTH). Currently, 
      HHcy is considered a novel independent risk factor for various cardiovascular 
      diseases. To provide a useful reference for clinicians, the research progress on 
      Hcy, HHcy and HTH in recent years was systematically reviewed here, with a focus 
      on the source and metabolic pathways of Hcy, plasma Hcy levels and influencing 
      factors, detection methods for plasma Hcy levels, relationship between Hcy 
      concentration and hypertension, pathogenesis of HTH, cardiovascular complications 
      of HTH, and treatment of HTH.
CI  - (c) The Author(s) 2024. Published by Oxford University Press on behalf of the 
      European Society of Cardiology. All rights reserved. For permissions, please 
      e-mail: journals.permissions@oup.com.
FAU - Wu, Dong-Feng
AU  - Wu DF
AD  - Department of Geriatric Cardiology, Guangxi Academy of Medical Sciences and the 
      People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, People's 
      Republic of China.
FAU - Yin, Rui-Xing
AU  - Yin RX
AUID- ORCID: 0000-0001-7883-4310
AD  - Department of Cardiology, Institute of Cardiovascular Diseases, The First 
      Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, People's 
      Republic of China.
FAU - Deng, Jin-Long
AU  - Deng JL
AD  - Department of Geriatric Cardiology, Guangxi Academy of Medical Sciences and the 
      People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, People's 
      Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20240117
PL  - England
TA  - Eur J Prev Cardiol
JT  - European journal of preventive cardiology
JID - 101564430
SB  - IM
CIN - Eur J Prev Cardiol. 2024 Feb 10;:. PMID: 38339989
OTO - NOTNLM
OT  - H-type hypertension
OT  - Homocysteine
OT  - hyperhomocysteinemia
OT  - research progress
EDAT- 2024/01/18 12:43
MHDA- 2024/01/18 12:43
CRDT- 2024/01/18 09:53
PHST- 2023/08/24 00:00 [received]
PHST- 2023/10/23 00:00 [revised]
PHST- 2024/01/15 00:00 [accepted]
PHST- 2024/01/18 12:43 [medline]
PHST- 2024/01/18 12:43 [pubmed]
PHST- 2024/01/18 09:53 [entrez]
AID - 7571316 [pii]
AID - 10.1093/eurjpc/zwae022 [doi]
PST - aheadofprint
SO  - Eur J Prev Cardiol. 2024 Jan 17:zwae022. doi: 10.1093/eurjpc/zwae022.