PMID- 38237580 OWN - NLM STAT- MEDLINE DCOM- 20240325 LR - 20240325 IS - 1555-0273 (Electronic) IS - 1555-0265 (Linking) VI - 19 IP - 4 DP - 2024 Apr 1 TI - Effects of In-Exercise Carbohydrate Supplementation on Prolonged High-Intensity Exercise Performance in Oral Contraceptive Users. PG - 356-364 LID - 10.1123/ijspp.2023-0143 [doi] AB - PURPOSE: To examine the impact of oral contraceptive (OC) phases on performance, physiological, and subjective responses to prolonged, intensive exercise when carbohydrate (CHO) stores are reduced. METHODS: Ten well-trained female cyclists using monophasic OC completed 4 identical trials (>150 min) under conditions of in-trial 60-g.h-1 CHO supplementation (CHO+) or placebo (CHO-) during the sugar- (SUG) and active-pill (ACT) phases of their OC cycle. Each trial comprised two 400-kcal time trials (TT) separated by 1 hour of submaximal cycling at first ventilatory threshold. RESULTS: Change in completion time from TT1 to TT2 was minimized in CHO+ compared with CHO- (4.06 [2.55] vs 6.08 [5.33] min; P = .019, effect size = -0.36). An interaction effect of OC and CHO was observed for time to complete TT (P = .006), mean TT power (P = .002), mean TT heart rate (P = .002), and posttrial emotional balance (P = .020) and negative emotional state (P = .033). In ACT, mean TT power and heart rate were higher in CHO+ when compared with CHO-, resulting in faster TTs in CHO+ and improved posttrial emotional well-being. When CHO was not supplemented, TT power and heart rate were higher in SUG when compared with ACT, resulting in faster TTs in SUG and improved posttrial emotional balance. CONCLUSION: CHO depletion during ACT negatively influenced TT performance and emotional well-being when compared with SUG. Irrespective of OC pill phase, CHO supplementation should be prioritized to sustain performance and improve postexercise recovery-stress balance. FAU - Lee, Serene J L AU - Lee SJL AD - Center for Healthy Aging, Murdoch University, Perth, WA, Australia. AD - Murdoch Applied Sports Science Laboratory, Murdoch University, Perth, WA, Australia. FAU - Van Rens, Fleur E C A AU - Van Rens FECA AUID- ORCID: 0000-0002-6305-3359 AD - Discipline of Exercise Science, Murdoch University, Perth, WA, Australia. FAU - Peiffer, Jeremiah J AU - Peiffer JJ AUID- ORCID: 0000-0002-3331-1177 AD - Center for Healthy Aging, Murdoch University, Perth, WA, Australia. AD - Murdoch Applied Sports Science Laboratory, Murdoch University, Perth, WA, Australia. LA - eng PT - Journal Article DEP - 20240118 PL - United States TA - Int J Sports Physiol Perform JT - International journal of sports physiology and performance JID - 101276430 RN - 0 (Dietary Carbohydrates) RN - 0 (Blood Glucose) RN - 0 (Contraceptives, Oral) SB - IM MH - Humans MH - Female MH - *Dietary Carbohydrates MH - *Exercise/physiology MH - Blood Glucose MH - Bicycling/physiology MH - Dietary Supplements MH - Contraceptives, Oral MH - Physical Endurance/physiology OTO - NOTNLM OT - endurance exercise OT - female athlete OT - nutrition OT - phase difference OT - time trial EDAT- 2024/01/19 00:42 MHDA- 2024/03/25 06:42 CRDT- 2024/01/18 18:36 PHST- 2023/04/10 00:00 [received] PHST- 2023/11/28 00:00 [revised] PHST- 2023/12/07 00:00 [accepted] PHST- 2024/03/25 06:42 [medline] PHST- 2024/01/19 00:42 [pubmed] PHST- 2024/01/18 18:36 [entrez] AID - 10.1123/ijspp.2023-0143 [doi] PST - epublish SO - Int J Sports Physiol Perform. 2024 Jan 18;19(4):356-364. doi: 10.1123/ijspp.2023-0143. Print 2024 Apr 1.