PMID- 38237779
OWN - NLM
STAT- MEDLINE
DCOM- 20240214
LR  - 20240214
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 351
DP  - 2024 Mar
TI  - Using Bayesian and weighted regression to evaluate the association of idiopathic 
      oligoastenoteratozoospermia with seminal plasma metal mixtures.
PG  - 141202
LID - S0045-6535(24)00095-X [pii]
LID - 10.1016/j.chemosphere.2024.141202 [doi]
AB  - Idiopathic oligoastenoteratozoospermia (iOAT) affects 30% of infertile men of 
      reproductive age. However, the associations between Cr, Fe, Cu, Se or Co levels 
      and iOAT risk have not been determined. This research aimed to assess the 
      associations between Cr, Fe, Cu, Se and Co levels as well as their mixtures in 
      seminal plasma and the risk of iOAT and severe iOAT. Therefore, a case‒control 
      study including 823 participants (416 iOAT patients and 407 controls) recruited 
      from October 2021 to August 2022 at the reproductive medicine center of the First 
      Affiliated Hospital of Anhui Medical University was conducted in Anhui, China. 
      The concentrations of Cr, Fe, Cu, Se and Co in seminal plasma were detected via 
      inductively coupled plasma‒mass spectrometry. Binary logistic regression models 
      were used to assess the associations between the levels of Cr, Fe, Cu, Se and Co 
      and the risk of iOAT and severe iOAT; additionally, Bayesian kernel machine 
      regression (BKMR) and weighted quantile sum (WQS) regressions were performed to 
      evaluate the joint effect of seminal plasma levels of Cr, Fe, Cu, Se and Co on 
      the risk of iOAT and explore which elements contributed most to the relationship. 
      We found significant associations between the concentrations of Fe, Cu and Se in 
      seminal plasma and iOAT risk after adjusting for covariates (Fe, lowest tertile 
      vs. second tertile: aOR = 1.86, 95% CI = 1.31, 2.64; Cu, lowest tertile vs. 
      second tertile: aOR = 1.95, 95% CI = 1.37, 2.76; Se, lowest tertile vs. second 
      tertile: aOR = 1.65, 95% CI = 1.17, 2.35). A lower Se concentration in seminal 
      plasma (lowest tertile vs. second tertile: aOR = 1.84, 95% CI = 1.10, 3.10) was 
      positively associated with the risk of severe iOAT. Additionally, we also 
      observed an association between the concentration of Cr in seminal plasma and the 
      risk of iOAT before adjusting for covariates (Cr, third tertile vs. lowest 
      tertile: OR=1.44, 95% CI: 1.03, 2.02). According to the BKMR analyses, the risk 
      of iOAT increased when the overall concentrations were less than the 25th 
      percentile. The results from the WQS regression indicated that a negative WQS 
      index was significantly associated with the iOAT risk, while a positive WQS index 
      was not. Se and Fe had significant weights in the negative direction. In 
      conclusion, lower Cu, Fe and Se levels in seminal plasma were positively 
      associated with iOAT risk, while higher Cr levels in seminal plasma were 
      positively associated with iOAT risk according to the single element model, and 
      lower levels of Se were related to a greater risk of severe iOAT; when 
      comprehensively considering all the results from BKMR and WQS regression, Fe, Se 
      and Cr levels contributed most to this relationship.
CI  - Copyright (c) 2024 Elsevier Ltd. All rights reserved.
FAU - Yin, Tao
AU  - Yin T
AD  - Department of Obstetrics and Gynaecology, the First Affiliated Hospital of Anhui 
      Medical University, No. 218 Jixi Road, Hefei, 230022, Anhui, China; NHC Key 
      Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical 
      University), No. 81 Meishan Road, Hefei, 230032, Anhui, China; Key Laboratory of 
      Population Health Across Life Cycle (Anhui Medical University), Ministry of 
      Education of the People's Republic of China, No. 81 Meishan Road, Hefei, 230032, 
      Anhui, China; Anhui Province Key Laboratory of Reproductive Health and Genetics, 
      No. 81 Meishan Road, Hefei, 230032, Anhui, China; Anhui Provincial Engineering 
      Research Center of Biopreservation and Artificial Organs, No. 81 Meishan Road, 
      Hefei, 230032, Anhui, China; Anhui Provincial Institute of Translational 
      Medicine, No. 81 Meishan Road, Hefei, 230032, Anhui, China.
FAU - Ji, Dongmei
AU  - Ji D
AD  - Department of Obstetrics and Gynaecology, the First Affiliated Hospital of Anhui 
      Medical University, No. 218 Jixi Road, Hefei, 230022, Anhui, China; NHC Key 
      Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical 
      University), No. 81 Meishan Road, Hefei, 230032, Anhui, China; Key Laboratory of 
      Population Health Across Life Cycle (Anhui Medical University), Ministry of 
      Education of the People's Republic of China, No. 81 Meishan Road, Hefei, 230032, 
      Anhui, China; Anhui Province Key Laboratory of Reproductive Health and Genetics, 
      No. 81 Meishan Road, Hefei, 230032, Anhui, China; Anhui Provincial Engineering 
      Research Center of Biopreservation and Artificial Organs, No. 81 Meishan Road, 
      Hefei, 230032, Anhui, China; Anhui Provincial Institute of Translational 
      Medicine, No. 81 Meishan Road, Hefei, 230032, Anhui, China.
FAU - Su, Xun
AU  - Su X
AD  - Department of Obstetrics and Gynaecology, the First Affiliated Hospital of Anhui 
      Medical University, No. 218 Jixi Road, Hefei, 230022, Anhui, China; NHC Key 
      Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical 
      University), No. 81 Meishan Road, Hefei, 230032, Anhui, China; Key Laboratory of 
      Population Health Across Life Cycle (Anhui Medical University), Ministry of 
      Education of the People's Republic of China, No. 81 Meishan Road, Hefei, 230032, 
      Anhui, China; Anhui Province Key Laboratory of Reproductive Health and Genetics, 
      No. 81 Meishan Road, Hefei, 230032, Anhui, China; Anhui Provincial Engineering 
      Research Center of Biopreservation and Artificial Organs, No. 81 Meishan Road, 
      Hefei, 230032, Anhui, China; Anhui Provincial Institute of Translational 
      Medicine, No. 81 Meishan Road, Hefei, 230032, Anhui, China.
FAU - Zhou, Xinyu
AU  - Zhou X
AD  - Department of Obstetrics and Gynaecology, the First Affiliated Hospital of Anhui 
      Medical University, No. 218 Jixi Road, Hefei, 230022, Anhui, China; NHC Key 
      Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical 
      University), No. 81 Meishan Road, Hefei, 230032, Anhui, China; Key Laboratory of 
      Population Health Across Life Cycle (Anhui Medical University), Ministry of 
      Education of the People's Republic of China, No. 81 Meishan Road, Hefei, 230032, 
      Anhui, China; Anhui Province Key Laboratory of Reproductive Health and Genetics, 
      No. 81 Meishan Road, Hefei, 230032, Anhui, China; Anhui Provincial Engineering 
      Research Center of Biopreservation and Artificial Organs, No. 81 Meishan Road, 
      Hefei, 230032, Anhui, China; Anhui Provincial Institute of Translational 
      Medicine, No. 81 Meishan Road, Hefei, 230032, Anhui, China.
FAU - Wang, Xin
AU  - Wang X
AD  - Department of Obstetrics and Gynaecology, the First Affiliated Hospital of Anhui 
      Medical University, No. 218 Jixi Road, Hefei, 230022, Anhui, China; NHC Key 
      Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical 
      University), No. 81 Meishan Road, Hefei, 230032, Anhui, China; Key Laboratory of 
      Population Health Across Life Cycle (Anhui Medical University), Ministry of 
      Education of the People's Republic of China, No. 81 Meishan Road, Hefei, 230032, 
      Anhui, China; Anhui Province Key Laboratory of Reproductive Health and Genetics, 
      No. 81 Meishan Road, Hefei, 230032, Anhui, China; Anhui Provincial Engineering 
      Research Center of Biopreservation and Artificial Organs, No. 81 Meishan Road, 
      Hefei, 230032, Anhui, China; Anhui Provincial Institute of Translational 
      Medicine, No. 81 Meishan Road, Hefei, 230032, Anhui, China.
FAU - He, Shitao
AU  - He S
AD  - School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei, 
      230032, Anhui, China.
FAU - Jiang, Tingting
AU  - Jiang T
AD  - School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei, 
      230032, Anhui, China.
FAU - Yue, Xinyu
AU  - Yue X
AD  - Department of Obstetrics and Gynaecology, the First Affiliated Hospital of Anhui 
      Medical University, No. 218 Jixi Road, Hefei, 230022, Anhui, China; NHC Key 
      Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical 
      University), No. 81 Meishan Road, Hefei, 230032, Anhui, China; Key Laboratory of 
      Population Health Across Life Cycle (Anhui Medical University), Ministry of 
      Education of the People's Republic of China, No. 81 Meishan Road, Hefei, 230032, 
      Anhui, China; Anhui Province Key Laboratory of Reproductive Health and Genetics, 
      No. 81 Meishan Road, Hefei, 230032, Anhui, China; Anhui Provincial Engineering 
      Research Center of Biopreservation and Artificial Organs, No. 81 Meishan Road, 
      Hefei, 230032, Anhui, China; Anhui Provincial Institute of Translational 
      Medicine, No. 81 Meishan Road, Hefei, 230032, Anhui, China.
FAU - Zhang, Hua
AU  - Zhang H
AD  - Department of Obstetrics and Gynaecology, the First Affiliated Hospital of Anhui 
      Medical University, No. 218 Jixi Road, Hefei, 230022, Anhui, China; NHC Key 
      Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical 
      University), No. 81 Meishan Road, Hefei, 230032, Anhui, China; Key Laboratory of 
      Population Health Across Life Cycle (Anhui Medical University), Ministry of 
      Education of the People's Republic of China, No. 81 Meishan Road, Hefei, 230032, 
      Anhui, China; Anhui Province Key Laboratory of Reproductive Health and Genetics, 
      No. 81 Meishan Road, Hefei, 230032, Anhui, China; Anhui Provincial Engineering 
      Research Center of Biopreservation and Artificial Organs, No. 81 Meishan Road, 
      Hefei, 230032, Anhui, China; Anhui Provincial Institute of Translational 
      Medicine, No. 81 Meishan Road, Hefei, 230032, Anhui, China.
FAU - Zhang, Ying
AU  - Zhang Y
AD  - Department of Obstetrics and Gynaecology, the First Affiliated Hospital of Anhui 
      Medical University, No. 218 Jixi Road, Hefei, 230022, Anhui, China; NHC Key 
      Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical 
      University), No. 81 Meishan Road, Hefei, 230032, Anhui, China; Key Laboratory of 
      Population Health Across Life Cycle (Anhui Medical University), Ministry of 
      Education of the People's Republic of China, No. 81 Meishan Road, Hefei, 230032, 
      Anhui, China; Anhui Province Key Laboratory of Reproductive Health and Genetics, 
      No. 81 Meishan Road, Hefei, 230032, Anhui, China; Anhui Provincial Engineering 
      Research Center of Biopreservation and Artificial Organs, No. 81 Meishan Road, 
      Hefei, 230032, Anhui, China; Anhui Provincial Institute of Translational 
      Medicine, No. 81 Meishan Road, Hefei, 230032, Anhui, China.
FAU - Peng, Jie
AU  - Peng J
AD  - Department of Obstetrics and Gynaecology, the First Affiliated Hospital of Anhui 
      Medical University, No. 218 Jixi Road, Hefei, 230022, Anhui, China; NHC Key 
      Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical 
      University), No. 81 Meishan Road, Hefei, 230032, Anhui, China; Key Laboratory of 
      Population Health Across Life Cycle (Anhui Medical University), Ministry of 
      Education of the People's Republic of China, No. 81 Meishan Road, Hefei, 230032, 
      Anhui, China; Anhui Province Key Laboratory of Reproductive Health and Genetics, 
      No. 81 Meishan Road, Hefei, 230032, Anhui, China; Anhui Provincial Engineering 
      Research Center of Biopreservation and Artificial Organs, No. 81 Meishan Road, 
      Hefei, 230032, Anhui, China; Anhui Provincial Institute of Translational 
      Medicine, No. 81 Meishan Road, Hefei, 230032, Anhui, China.
FAU - Zou, Weiwei
AU  - Zou W
AD  - Department of Obstetrics and Gynaecology, the First Affiliated Hospital of Anhui 
      Medical University, No. 218 Jixi Road, Hefei, 230022, Anhui, China; NHC Key 
      Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical 
      University), No. 81 Meishan Road, Hefei, 230032, Anhui, China; Key Laboratory of 
      Population Health Across Life Cycle (Anhui Medical University), Ministry of 
      Education of the People's Republic of China, No. 81 Meishan Road, Hefei, 230032, 
      Anhui, China; Anhui Province Key Laboratory of Reproductive Health and Genetics, 
      No. 81 Meishan Road, Hefei, 230032, Anhui, China; Anhui Provincial Engineering 
      Research Center of Biopreservation and Artificial Organs, No. 81 Meishan Road, 
      Hefei, 230032, Anhui, China; Anhui Provincial Institute of Translational 
      Medicine, No. 81 Meishan Road, Hefei, 230032, Anhui, China.
FAU - Liang, Dan
AU  - Liang D
AD  - Department of Obstetrics and Gynaecology, the First Affiliated Hospital of Anhui 
      Medical University, No. 218 Jixi Road, Hefei, 230022, Anhui, China; NHC Key 
      Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical 
      University), No. 81 Meishan Road, Hefei, 230032, Anhui, China; Key Laboratory of 
      Population Health Across Life Cycle (Anhui Medical University), Ministry of 
      Education of the People's Republic of China, No. 81 Meishan Road, Hefei, 230032, 
      Anhui, China; Anhui Province Key Laboratory of Reproductive Health and Genetics, 
      No. 81 Meishan Road, Hefei, 230032, Anhui, China; Anhui Provincial Engineering 
      Research Center of Biopreservation and Artificial Organs, No. 81 Meishan Road, 
      Hefei, 230032, Anhui, China; Anhui Provincial Institute of Translational 
      Medicine, No. 81 Meishan Road, Hefei, 230032, Anhui, China.
FAU - Liu, Yajing
AU  - Liu Y
AD  - Department of Obstetrics and Gynaecology, the First Affiliated Hospital of Anhui 
      Medical University, No. 218 Jixi Road, Hefei, 230022, Anhui, China; NHC Key 
      Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical 
      University), No. 81 Meishan Road, Hefei, 230032, Anhui, China; Key Laboratory of 
      Population Health Across Life Cycle (Anhui Medical University), Ministry of 
      Education of the People's Republic of China, No. 81 Meishan Road, Hefei, 230032, 
      Anhui, China; Anhui Province Key Laboratory of Reproductive Health and Genetics, 
      No. 81 Meishan Road, Hefei, 230032, Anhui, China; Anhui Provincial Engineering 
      Research Center of Biopreservation and Artificial Organs, No. 81 Meishan Road, 
      Hefei, 230032, Anhui, China; Anhui Provincial Institute of Translational 
      Medicine, No. 81 Meishan Road, Hefei, 230032, Anhui, China.
FAU - Du, Yinan
AU  - Du Y
AD  - School of Basic Medical Sciences, Anhui Medical University, No. 81 Meishan Road, 
      Hefei, 230032, Anhui, China.
FAU - Zhang, Zhiguo
AU  - Zhang Z
AD  - Department of Obstetrics and Gynaecology, the First Affiliated Hospital of Anhui 
      Medical University, No. 218 Jixi Road, Hefei, 230022, Anhui, China; NHC Key 
      Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical 
      University), No. 81 Meishan Road, Hefei, 230032, Anhui, China; Key Laboratory of 
      Population Health Across Life Cycle (Anhui Medical University), Ministry of 
      Education of the People's Republic of China, No. 81 Meishan Road, Hefei, 230032, 
      Anhui, China; Anhui Province Key Laboratory of Reproductive Health and Genetics, 
      No. 81 Meishan Road, Hefei, 230032, Anhui, China; Anhui Provincial Engineering 
      Research Center of Biopreservation and Artificial Organs, No. 81 Meishan Road, 
      Hefei, 230032, Anhui, China; Anhui Provincial Institute of Translational 
      Medicine, No. 81 Meishan Road, Hefei, 230032, Anhui, China.
FAU - Liang, Chunmei
AU  - Liang C
AD  - Department of Obstetrics and Gynaecology, the First Affiliated Hospital of Anhui 
      Medical University, No. 218 Jixi Road, Hefei, 230022, Anhui, China; School of 
      Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei, 230032, 
      Anhui, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive 
      Tract (Anhui Medical University), No. 81 Meishan Road, Hefei, 230032, Anhui, 
      China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical 
      University), Ministry of Education of the People's Republic of China, No. 81 
      Meishan Road, Hefei, 230032, Anhui, China; Anhui Province Key Laboratory of 
      Reproductive Health and Genetics, No. 81 Meishan Road, Hefei, 230032, Anhui, 
      China; Anhui Provincial Engineering Research Center of Biopreservation and 
      Artificial Organs, No. 81 Meishan Road, Hefei, 230032, Anhui, China; Anhui 
      Provincial Institute of Translational Medicine, No. 81 Meishan Road, Hefei, 
      230032, Anhui, China. Electronic address: liang_chun_mei@126.com.
FAU - Cao, Yunxia
AU  - Cao Y
AD  - Department of Obstetrics and Gynaecology, the First Affiliated Hospital of Anhui 
      Medical University, No. 218 Jixi Road, Hefei, 230022, Anhui, China; NHC Key 
      Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical 
      University), No. 81 Meishan Road, Hefei, 230032, Anhui, China; Key Laboratory of 
      Population Health Across Life Cycle (Anhui Medical University), Ministry of 
      Education of the People's Republic of China, No. 81 Meishan Road, Hefei, 230032, 
      Anhui, China; Anhui Province Key Laboratory of Reproductive Health and Genetics, 
      No. 81 Meishan Road, Hefei, 230032, Anhui, China; Anhui Provincial Engineering 
      Research Center of Biopreservation and Artificial Organs, No. 81 Meishan Road, 
      Hefei, 230032, Anhui, China; Anhui Provincial Institute of Translational 
      Medicine, No. 81 Meishan Road, Hefei, 230032, Anhui, China. Electronic address: 
      caoyunxia5972@ahmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20240116
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Metals)
SB  - IM
MH  - Male
MH  - Humans
MH  - *Semen/chemistry
MH  - Bayes Theorem
MH  - Case-Control Studies
MH  - *Metals/analysis
MH  - Logistic Models
OTO - NOTNLM
OT  - Bayesian kernel machine regression
OT  - Essential trace elements
OT  - Oligoastenoteratozoospermia
OT  - Sperm quality
OT  - Weighted quantile sum (WQS) regression
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2024/01/19 00:42
MHDA- 2024/02/14 12:50
CRDT- 2024/01/18 19:15
PHST- 2023/04/06 00:00 [received]
PHST- 2024/01/09 00:00 [revised]
PHST- 2024/01/11 00:00 [accepted]
PHST- 2024/02/14 12:50 [medline]
PHST- 2024/01/19 00:42 [pubmed]
PHST- 2024/01/18 19:15 [entrez]
AID - S0045-6535(24)00095-X [pii]
AID - 10.1016/j.chemosphere.2024.141202 [doi]
PST - ppublish
SO  - Chemosphere. 2024 Mar;351:141202. doi: 10.1016/j.chemosphere.2024.141202. Epub 
      2024 Jan 16.