PMID- 38238371
OWN - NLM
STAT- MEDLINE
DCOM- 20240122
LR  - 20240202
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 14
IP  - 1
DP  - 2024 Jan 18
TI  - Validation of reliability, repeatability and consistency of three-dimensional 
      choroidal vascular index.
PG  - 1576
LID - 10.1038/s41598-024-51922-x [doi]
LID - 1576
AB  - This study aimed to investigate the reliability, repeatability and consistency of 
      choroidal vascularity index (CVI) measurements provided by an artificial 
      intelligence-based software in swept-source optical coherence tomography (SS-OCT) 
      in normal subject, and to evaluate the influencing factors for 3D-CVI. 
      Repeatability of 3D-CVI by SS-OCT was evaluated based on different scanning modes 
      including Macular Cubes (3 mm x 3 mm, 6 mm x 6 mm, 9 mm x 9 mm) and Optic Nerve 
      Head 6 mm x 6 mm. Intraclass Correlation Coefficient (ICC) was used to estimate 
      the repeatability and reproducibility of five repeated measurement by SS-OCT. 
      Consistency of CVI between SS-OCT and spectral-domain optical coherence 
      tomography (SD-OCT) was measured and compared in a pilot study of ten eyes and 
      agreement between SS-OCT and SD-OCT was evaluated by Bland-Altman analysis and 
      Deming regression. The influencing factors for 3D-CVI including age, gender, 
      axial length and spherical equivalent on CVI was further investigated in a 
      prospective study of 125 eyes of 125 healthy subjects. ICC between different 
      measurements by SS-OCT was 0.934 (95% CI 0.812-0.956) indicating good 
      repeatability. Intraclass correlation coefficient between CVI measure by SS-OCT 
      and SD-OCT was 0.887 (95% CI 0.796-0.938, P value < 0.001). The mean difference 
      between 3D-CVI measured by SS-OCT and SD-OCT 0.133. CVI measured with SS-OCTA 
      showed stronger correlations with axial length and age but not correlated with 
      gender. There is good agreement between CVIs obtained from the built-in software 
      that requires less timing in manual quantification. Studies investigating 
      choroidal vascularity can be standardized by the AI-based CVI analyze software.
CI  - (c) 2024. The Author(s).
FAU - Ma, Feiyan
AU  - Ma F
AD  - The Second Hospital of Hebei Medical University, 215 Heping Road, Shijiazhuang, 
      Hebei Province, China.
FAU - Bai, Yifan
AU  - Bai Y
AD  - The Second Hospital of Hebei Medical University, 215 Heping Road, Shijiazhuang, 
      Hebei Province, China.
FAU - Duan, Jialiang
AU  - Duan J
AD  - The Second Hospital of Hebei Medical University, 215 Heping Road, Shijiazhuang, 
      Hebei Province, China.
FAU - Liang, Yuchen
AU  - Liang Y
AD  - The Second Hospital of Hebei Medical University, 215 Heping Road, Shijiazhuang, 
      Hebei Province, China.
FAU - Shang, Qingli
AU  - Shang Q
AD  - The Second Hospital of Hebei Medical University, 215 Heping Road, Shijiazhuang, 
      Hebei Province, China. shangqingli2020@163.com.
LA  - eng
GR  - 20200069/Hebei Province Medical Science Research Key Project/
PT  - Journal Article
DEP - 20240118
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Humans
MH  - Reproducibility of Results
MH  - Prospective Studies
MH  - *Artificial Intelligence
MH  - Pilot Projects
MH  - *Choroid/diagnostic imaging/blood supply
MH  - Tomography, Optical Coherence/methods
PMC - PMC10796765
COIS- The authors declare no competing interests.
EDAT- 2024/01/19 00:42
MHDA- 2024/01/22 06:43
PMCR- 2024/01/18
CRDT- 2024/01/18 23:18
PHST- 2023/08/06 00:00 [received]
PHST- 2024/01/11 00:00 [accepted]
PHST- 2024/01/22 06:43 [medline]
PHST- 2024/01/19 00:42 [pubmed]
PHST- 2024/01/18 23:18 [entrez]
PHST- 2024/01/18 00:00 [pmc-release]
AID - 10.1038/s41598-024-51922-x [pii]
AID - 51922 [pii]
AID - 10.1038/s41598-024-51922-x [doi]
PST - epublish
SO  - Sci Rep. 2024 Jan 18;14(1):1576. doi: 10.1038/s41598-024-51922-x.