PMID- 38238452
OWN - NLM
STAT- MEDLINE
DCOM- 20240408
LR  - 20240408
IS  - 1476-5365 (Electronic)
IS  - 0268-3369 (Linking)
VI  - 59
IP  - 4
DP  - 2024 Apr
TI  - Prognostic impact of HLA supertype mismatch in single-unit cord blood 
      transplantation.
PG  - 466-472
LID - 10.1038/s41409-023-02183-1 [doi]
AB  - The "human leukocyte antigen (HLA) supertype" is a functional classification of 
      HLA alleles, which was defined by structural features and peptide specificities, 
      and has been reportedly associated with the clinical outcomes of viral infections 
      and autoimmune diseases. Although the disparity in each HLA locus was reported to 
      have no clinical significance in single-unit cord blood transplantation (sCBT), 
      the clinical significance of the HLA supertype in sCBT remains unknown. 
      Therefore, we retrospectively analyzed clinical data of 1603 patients who 
      received sCBT in eight institutes in Japan between 2000 and 2017. Each HLA allele 
      was categorized into 19 supertypes, and the prognostic effect of disparities was 
      then assessed. An HLA-B supertype mismatch was identified as a poor prognostic 
      factor (PFS: hazard ratio [HR] = 1.23, p = 0.00044) and was associated with a 
      higher cumulative incidence (CI) of relapse (HR = 1.24, p = 0.013). However, an 
      HLA-B supertype mismatch was not associated with the CI of acute and chronic 
      graft-versus-host-disease. The multivariate analysis for relapse and PFS showed 
      the significance of an HLA-B supertype mismatch independent of allelic 
      mismatches, and other previously reported prognostic factors. HLA-B 
      supertype-matched grafts should be selected in sCBT.
CI  - (c) 2024. The Author(s), under exclusive licence to Springer Nature Limited.
FAU - Sugio, Takeshi
AU  - Sugio T
AD  - Department of Medicine and Biosystemic Science, Kyushu University Graduate School 
      of Medical Sciences, Fukuoka, Japan.
AD  - Divisions of Oncology and Hematology, Department of Medicine, Stanford 
      University, Stanford, CA, USA.
FAU - Uchida, Naoyuki
AU  - Uchida N
AUID- ORCID: 0000-0001-5952-5926
AD  - Department of Hematology, Toranomon Hospital, Tokyo, Japan.
FAU - Miyawaki, Kohta
AU  - Miyawaki K
AD  - Department of Medicine and Biosystemic Science, Kyushu University Graduate School 
      of Medical Sciences, Fukuoka, Japan.
FAU - Ohno, Yuju
AU  - Ohno Y
AD  - Department of Hematology, Kitakyushu Municipal Medical Center, Fukuoka, Japan.
FAU - Eto, Tetsuya
AU  - Eto T
AD  - Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan.
FAU - Mori, Yasuo
AU  - Mori Y
AUID- ORCID: 0000-0001-6425-1720
AD  - Department of Medicine and Biosystemic Science, Kyushu University Graduate School 
      of Medical Sciences, Fukuoka, Japan.
FAU - Yoshimoto, Goichi
AU  - Yoshimoto G
AD  - Department of Medicine and Biosystemic Science, Kyushu University Graduate School 
      of Medical Sciences, Fukuoka, Japan.
FAU - Kikushige, Yoshikane
AU  - Kikushige Y
AD  - Department of Medicine and Biosystemic Science, Kyushu University Graduate School 
      of Medical Sciences, Fukuoka, Japan.
FAU - Kunisaki, Yuya
AU  - Kunisaki Y
AUID- ORCID: 0000-0003-0141-7038
AD  - Department of Medicine and Biosystemic Science, Kyushu University Graduate School 
      of Medical Sciences, Fukuoka, Japan.
FAU - Mizuno, Shinichi
AU  - Mizuno S
AD  - Department of Health Sciences, Faculty of Medical Sciences, Kyushu University, 
      Fukuoka, Japan.
FAU - Nagafuji, Koji
AU  - Nagafuji K
AUID- ORCID: 0000-0003-4795-121X
AD  - Department of Medicine, Kurume University School of Medicine, Fukuoka, Japan.
FAU - Iwasaki, Hiromi
AU  - Iwasaki H
AD  - Department of Hematology, National Hospital Organization Kyushu Medical Center, 
      Fukuoka, Japan.
FAU - Kamimura, Tomohiko
AU  - Kamimura T
AD  - Department of Hematology, Harasanshin Hospital, Fukuoka, Japan.
FAU - Ogawa, Ryosuke
AU  - Ogawa R
AD  - Department of Hematology, JCHO Kyushu Hospital, Fukuoka, Japan.
FAU - Miyamoto, Toshihiro
AU  - Miyamoto T
AD  - Department of Hematology, Faculty of Medicine, Institute of Medical, 
      Pharmaceutical and Health Sciences, Kanazawa University, Ishikawa, Japan.
FAU - Taniguchi, Shuichi
AU  - Taniguchi S
AD  - Department of Hematology, Toranomon Hospital, Tokyo, Japan.
AD  - Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan.
FAU - Akashi, Koichi
AU  - Akashi K
AD  - Department of Medicine and Biosystemic Science, Kyushu University Graduate School 
      of Medical Sciences, Fukuoka, Japan.
FAU - Kato, Koji
AU  - Kato K
AD  - Department of Medicine and Biosystemic Science, Kyushu University Graduate School 
      of Medical Sciences, Fukuoka, Japan. kato.koji.429@m.kyushu-u.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20240118
PL  - England
TA  - Bone Marrow Transplant
JT  - Bone marrow transplantation
JID - 8702459
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens)
RN  - 0 (HLA-B Antigens)
SB  - IM
MH  - Humans
MH  - Prognosis
MH  - Retrospective Studies
MH  - *Cord Blood Stem Cell Transplantation
MH  - HLA Antigens
MH  - Histocompatibility Antigens
MH  - HLA-B Antigens/genetics
MH  - Recurrence
MH  - *Graft vs Host Disease
MH  - Alleles
MH  - Histocompatibility Testing
EDAT- 2024/01/19 00:42
MHDA- 2024/04/08 06:42
CRDT- 2024/01/18 23:22
PHST- 2023/04/29 00:00 [received]
PHST- 2023/12/12 00:00 [accepted]
PHST- 2023/11/26 00:00 [revised]
PHST- 2024/04/08 06:42 [medline]
PHST- 2024/01/19 00:42 [pubmed]
PHST- 2024/01/18 23:22 [entrez]
AID - 10.1038/s41409-023-02183-1 [pii]
AID - 10.1038/s41409-023-02183-1 [doi]
PST - ppublish
SO  - Bone Marrow Transplant. 2024 Apr;59(4):466-472. doi: 10.1038/s41409-023-02183-1. 
      Epub 2024 Jan 18.