PMID- 38239986
OWN - NLM
STAT- MEDLINE
DCOM- 20240122
LR  - 20240304
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 14
DP  - 2023
TI  - Association between neutrophil-to-lymphocyte ratio and diabetic kidney disease in 
      type 2 diabetes mellitus patients: a cross-sectional study.
PG  - 1285509
LID - 10.3389/fendo.2023.1285509 [doi]
LID - 1285509
AB  - AIMS: This investigation examined the possibility of a relationship between 
      neutrophil-to-lymphocyte ratio (NLR) and diabetic kidney disease (DKD) in type 2 
      diabetes mellitus (T2DM) patients. METHODS: Adults with T2DM who were included in 
      the National Health and Nutrition Examination Survey (NHANES) between 1999 and 
      2020 were the subjects of the current cross-sectional investigation. Low 
      estimated glomerular filtration rate (eGFR) (< 60 mL/min/1.73 m(2)) or 
      albuminuria (urinary albumin-to-creatinine ratio (ACR) >/= 30 mg/g) in T2DM 
      patients were the diagnostic criteria for DKD. Weighted multivariable logistic 
      regression models and generalized additive models were used to investigate the 
      independent relationships between NLR levels with DKD, albuminuria, and low-eGFR. 
      Additionally, we examined the relationships between DKD, albuminuria, and 
      low-eGFR with other inflammatory markers, such as the aggregate index of systemic 
      inflammation (AISI), systemic immune-inflammation index (SII), system 
      inflammation response index (SIRI), and platelet-to-lymphocyte ratio (PLR) and 
      monocyte-to-lymphocyte ratio (MLR). Their diagnostic capabilities were evaluated 
      and contrasted using receiver operating characteristic (ROC) curves. RESULTS: 
      44.65% of the 7,153 participants who were recruited for this study were males. 
      DKD, albuminuria, and low-eGFR were prevalent in 31.76%, 23.08%, and 14.55% of 
      cases, respectively. Positive correlations were seen between the NLR with the 
      prevalences of DKD, albuminuria, and low-eGFR. Subgroup analysis and interaction 
      tests revealed that the associations of NLR with DKD, albuminuria, and low-eGFR 
      were not significantly different across populations. In addition, MLR, SII and 
      SIRI showed positive associations with the prevalence of DKD. ROC analysis 
      discovered that when compared to other inflammatory markers (MLR, PLR, SII, SIRI, 
      and AISI), NLR may demonstrate more discriminatory power and accuracy in 
      assessing the risk of DKD, albuminuria, and low-eGFR. CONCLUSION: Compared to 
      other inflammatory markers (MLR, PLR, SII, SIRI, and AISI), NLR may serve as the 
      more effective potential inflammatory marker for identifying the risk of DKD, 
      albuminuria, and low-eGFR in US T2DM patients. T2DM patients with elevated levels 
      of NLR, MLR, SII, and SIRI should be closely monitored for their potential risk 
      to renal function.
CI  - Copyright (c) 2024 Li, Wang, Liu, Zhou and Xu.
FAU - Li, Xiaowan
AU  - Li X
AD  - Department of Critical Care Medicine, The Affiliated Wuxi People's Hospital of 
      Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing 
      Medical University, Wuxi, China.
FAU - Wang, Lanyu
AU  - Wang L
AD  - Department of Urology, The Affiliated Wuxi People's Hospital of Nanjing Medical 
      University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical 
      University, Wuxi, China.
FAU - Liu, Min
AU  - Liu M
AD  - Department of Critical Care Medicine, The Affiliated Wuxi People's Hospital of 
      Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing 
      Medical University, Wuxi, China.
FAU - Zhou, Hongyi
AU  - Zhou H
AD  - Department of Urology, The Affiliated Wuxi People's Hospital of Nanjing Medical 
      University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical 
      University, Wuxi, China.
FAU - Xu, Hongyang
AU  - Xu H
AD  - Department of Critical Care Medicine, The Affiliated Wuxi People's Hospital of 
      Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing 
      Medical University, Wuxi, China.
LA  - eng
PT  - Journal Article
DEP - 20240104
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
SB  - IM
MH  - Male
MH  - Adult
MH  - Humans
MH  - Female
MH  - *Diabetic Nephropathies/etiology/complications
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Cross-Sectional Studies
MH  - Nutrition Surveys
MH  - Neutrophils
MH  - Albuminuria/etiology
MH  - Lymphocytes
MH  - Inflammation/complications
PMC - PMC10795842
OTO - NOTNLM
OT  - NHANES
OT  - diabetic kidney disease
OT  - neutrophil-to-lymphocyte ratio
OT  - population-based study
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2024/01/19 06:42
MHDA- 2024/01/22 06:42
PMCR- 2023/01/01
CRDT- 2024/01/19 03:49
PHST- 2023/08/30 00:00 [received]
PHST- 2023/11/30 00:00 [accepted]
PHST- 2024/01/22 06:42 [medline]
PHST- 2024/01/19 06:42 [pubmed]
PHST- 2024/01/19 03:49 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2023.1285509 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2024 Jan 4;14:1285509. doi: 
      10.3389/fendo.2023.1285509. eCollection 2023.