PMID- 38242883
OWN - NLM
STAT- MEDLINE
DCOM- 20240122
LR  - 20240201
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 14
IP  - 1
DP  - 2024 Jan 19
TI  - Predictive value of serum TBA for 2-year MACEs in ACS patients undergoing PCI: a 
      prospective cohort study.
PG  - 1733
LID - 10.1038/s41598-023-50304-z [doi]
LID - 1733
AB  - Bile acids play important roles in lipid metabolism and glucose homeostasis. 
      Limited research exist on the association between serum total bile acid (TBA) 
      levels and major adverse cardiovascular events (MACEs) in patients with acute 
      coronary syndrome (ACS), particularly those with comorbid type 2 diabetes 
      mellitus (T2DM). This study was conducted to examine the relationship between 
      baseline serum TBA level and T2DM status in patients with ACS after percutaneous 
      coronary intervention (PCI) and to identify the predictive value of TBA levels 
      for a 2-year risk of MACEs. 425 ACS patients underwent PCI were recruited and 
      divided into three groups based on baseline serum TBA concentration. An analysis 
      of the association between the T2DM status and baseline serum TBA levels was 
      conducted using univariate linear regression and multivariate linear regression. 
      The predictive relevance of serum TBA levels was evaluated using the receiver 
      operating characteristic (ROC) curve and Cox regression. Kaplan-Meier curves were 
      employed to analyze the differences among groups in predicting MACEs over a 
      2-year follow-up period. Baseline serum TBA levels were higher in ACS patients 
      who were diagnosed with T2DM (the median 3.6 micromol/L) than those without T2DM (the 
      median 3.0 micromol/L). T2DM status in ACS patients was positively correlated with 
      baseline serum TBA concentrations (beta: 1.7, 95% confidence interval [CI] 0.3-3.0), 
      particularly in the male (beta: 2.0, 95% CI 0.3-3.6) and 50-69-year-old (beta: 2.5, 95% 
      CI 0.6-4.4) populations. The areas under the ROC curve of baseline serum TBA 
      levels predicted MACEs in ACS and ACS-T2DM patients following PCI were 0.649 (95% 
      CI 0.595-0.703) and 0.783 (95% CI 0.685-0.881), respectively. Furthermore, Cox 
      regression analysis showed that baseline serum TBA level was associated with the 
      occurrence of MACEs in patients with ACS after PCI over a 2-year follow-up 
      period, especially in those diagnosed with T2DM, whose baseline TBA concentration 
      was lower than 10.0 micromol/L. ACS Patients with T2DM had higher serum TBA levels. 
      TBA level at baseline was an independent predictor of MACEs in ACS patients who 
      underwent PCI, especially with comorbid T2DM.
CI  - (c) 2024. The Author(s).
FAU - Wen, Wen
AU  - Wen W
AD  - Department of Ultrasound, Clinical Medical College, First Affiliated Hospital of 
      Chengdu Medical College, Chengdu, China. septem0420@qq.com.
FAU - Li, Qinze
AU  - Li Q
AD  - Department of Ultrasound, Clinical Medical College, First Affiliated Hospital of 
      Chengdu Medical College, Chengdu, China.
FAU - She, Jianqing
AU  - She J
AD  - Department of Cardiovascular Medicine, First Affiliated Hospital, Xi'an Jiaotong 
      University, Xi'an, China.
FAU - Bai, Xiaofang
AU  - Bai X
AD  - Department of Ultrasound, First Affiliated Hospital, Xi'an Jiaotong University, 
      Xi'an, China.
FAU - Zhang, Lisha
AU  - Zhang L
AD  - Department of Cardiology, Second Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, China.
FAU - Li, Ruifeng
AU  - Li R
AD  - Department of Cardiovascular Medicine, First Affiliated Hospital, Xi'an Jiaotong 
      University, Xi'an, China.
FAU - Wu, Yan
AU  - Wu Y
AD  - Department of Cardiovascular Medicine, First Affiliated Hospital, Xi'an Jiaotong 
      University, Xi'an, China.
FAU - Zhou, Juan
AU  - Zhou J
AD  - Department of Cardiovascular Medicine, First Affiliated Hospital, Xi'an Jiaotong 
      University, Xi'an, China.
AD  - Key Laboratory of Molecular Cardiology, Xi'an, Shaanxi Province, China.
FAU - Yuan, Zuyi
AU  - Yuan Z
AD  - Department of Cardiovascular Medicine, First Affiliated Hospital, Xi'an Jiaotong 
      University, Xi'an, China. zuyiyuan@mail.xjtu.edu.cn.
AD  - Key Laboratory of Molecular Cardiology, Xi'an, Shaanxi Province, China. 
      zuyiyuan@mail.xjtu.edu.cn.
AD  - Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong 
      University), Ministry of Education, Xi'an, China. zuyiyuan@mail.xjtu.edu.cn.
LA  - eng
GR  - 81800446/National Natural Science Foundation of China/
GR  - CYFY-GQ57/Scientific Research Project of First Affiliated Hospital of Chengdu 
      Medical College/
PT  - Journal Article
DEP - 20240119
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Humans
MH  - Male
MH  - *Acute Coronary Syndrome
MH  - *Percutaneous Coronary Intervention/adverse effects
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Prospective Studies
MH  - Heart
MH  - Risk Factors
PMC - PMC10799034
COIS- The authors declare no competing interests.
EDAT- 2024/01/20 05:41
MHDA- 2024/01/22 06:41
PMCR- 2024/01/19
CRDT- 2024/01/19 23:14
PHST- 2023/06/20 00:00 [received]
PHST- 2023/12/18 00:00 [accepted]
PHST- 2024/01/22 06:41 [medline]
PHST- 2024/01/20 05:41 [pubmed]
PHST- 2024/01/19 23:14 [entrez]
PHST- 2024/01/19 00:00 [pmc-release]
AID - 10.1038/s41598-023-50304-z [pii]
AID - 50304 [pii]
AID - 10.1038/s41598-023-50304-z [doi]
PST - epublish
SO  - Sci Rep. 2024 Jan 19;14(1):1733. doi: 10.1038/s41598-023-50304-z.